Alex: Why would you wanna help me after what I did?
Izzie: Because, it's what Jesus would freakin' do!

Nurse: Chief, Adelle just called.
Chief: Tell her I'm ---
Nurse: She knows you're not in surgery and she said to tell you, quote: We are going to our niece's school pageant this morning. You have known about it for months. And after what you pulled on Thanksgiving, than she started using a great many word that I don't feel comfortable repeating.
Chief: Look - I have 7 surgeons on vacation.
Nurse: There was something about divorce.

(At the beginning of the episode)
Derek: Hey.
Meredith: Hey! You okay? You seem ...
Derek: Yeah. You know ... holidays.
Meredith: Oh. Yeah. I do know.

(At the end of the episode)
Derek: Hey.
Meredith: Hey.
Derek: You okay?
Meredith: Yeah, yeah. You know, holidays.
Derek: Yeah. I do know.

George: It looks like Santa threw up in here.

Derek: (to Addison) I'm not saying this to hurt you or because I want to leave you, because I don't. Meredith wasn't a fling. She wasn't revenge. I fell in love with her. That doesn't go away because I decided to stay with you.

Christina: I'm a 55 year old man. I'm nauseous and I can't stop throwing up.
Alex: Forget it alright. I didn't ask for anybody's help.
Christina: Look evil spawn, you can nurse your pride, key word being nurse. Or you can pass your test and be a doctor. Up to you.
Alex: (pauses) Any abdominal pain.
Christina: Yes, from my giant fat belly all the way to my back. Oh and I'm drunk. Hiccup. Hiccup.

In the scene where Derek is looking at the brain scan and Addison walks in, he is rolling his headphones around his iPod then puts it in his pocket. However, when he stands up to walk out, the headphones are around is neck.

Episode Title: Grandma Got Run Over By A Reindeer

"Grandma Got Run Over By A Reindeer" is the title of a popular Christmas song that has been recorded by The Beatles, Randy Brooks, and Elmo & Patsy.