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As the new year unfolds, Izzie vows to let Alex's affair go, and it comes easier when she hits it off with Denny Duquette, a heart transplant patient. George treats Bex, a teen hermaphrodite, with a tumor and Alex treats a man who ate his novel after not being pleased with the results. Meanwhile, Derek talks with Meredith's mom, Addison expresses her disgust with Derek's living arrangements, and the residents, especially Cristina, have a hard time dealing with the new work limit.
Meredith (opening voiceover): Fresh starts thanks to the calendar they happen every year --just set your watch to January, our reward for surviving the holiday season is a new year. Bringing on the great tradition of new years resolutions, put your past behind you and start over. It's hard to resist the chance of a new beginning, a chance to put the problems of last year to bed.
George: We need to talk about the dog.
Izzie: That's not a dog. It's a hyena escaped from the zoo, and dressed in dog clothing.
Richard: Cranky nurses don't do us any good.
Izzie: (to Alex) Oh, well, maybe you can cheer them up.
George: ... well, then, why?
Bex: I'm as flat as a board. I took like five of those pills a day.
George: (looks confused)
Bex: Boobs, dude!
Derek: (to Addison) There is a land called Passive Agressiva, and you are their queen.
George: In high school I was secretary and treasurer of the Dungeons & Dragons club.
Bex: Oh man..
Meredith: I've moved on. So don't give me that look.
Derek: What look?
Meredith: That look. Our look. I'm over you.
Derek: I'm over you too.
Meredith: You are?
Meredith: Well, I am... Over you.
Derek: I'm over you too.
Meredith: You just said-- shut up.
George: Your lab work...showed...have you been taking birth control pills?
Bex: If you tell my mom and dad they'll-
George: I won't! I won't--I just need to know...why? Do you have a boyfriend?
Bex: Like anyone would want to have sex with me--
Bex: I'm as flat as a board. I took like five of those pills a day and nothing's different. Boobs, dude.
George: You...were trying to make your breasts grow.
Bex: I wanted to be normal for once in my life.
Cristina: I wasn't gonna have it. The baby. And you don't get to be mad about that. We barely knew each other. I was an intern, and there was no way that I could have even...
Burke: I'm not mad.
Cristina: You're not?
Burke: No. I just wanted to know. I want to know things.
Bailey: I hope seeing you here means that they finally found you a heart.
Denny: No offence doctor but I'm not a big fan of hospitals. It takes something pretty special to get me in here.
Bailey (to Izzie): What do we know about Mr Duquette?
Denny: Capricorn, single, loves to travel and cook.
Bailey: Denny be quiet. Let her show off.
George: Hey, aren't you supposed to be having free time?
Meredith: Oh, I did 5 loads of laundry. Cut my split ends, studied, cleaned out the fridge. Free time sucks.
George: When would have been the best time to hear about your boyfriend's wife?
Meredith (gives him a look): Okay, are you mad at me or something?
George: No! No. Sorry. It's just I have this patient and I get that there's a right and a wrong time to hear big news but wouldn't you rather no sooner than later? I mean just so you could move forward one way or the other. It's a fresh start, right?
Meredith (closing voiceover): Who gets to determine when the old ends and the new begins? It's not on the calendar, it's not a birthday, it's not a new year, it's an event --big or small, something that changes us, ideally it gives us hope, a new way of living and looking at the world, letting go of old habits, old memories. What's important is that we never stop believing we can have a new beginning, but it's also important to remember amid all the crap are a few things really worth holding on to.