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As the new year unfolds, Izzie vows to let Alex's affair go, and it comes easier when she hits it off with Denny Duquette, a heart transplant patient. George treats Bex, a teen hermaphrodite, with a tumor and Alex treats a man who ate his novel after not being pleased with the results. Meanwhile, Derek talks with Meredith's mom, Addison expresses her disgust with Derek's living arrangements, and the residents, especially Cristina, have a hard time dealing with the new work limit.
This episode (finally!) featured the full 30-second themesong again, as opposed to the shortened 5-seconds version the past few weeks.
This is the first appearance of Jeffrey Dean Morgan (Denny Duquette).
George: We need to talk about the dog.
Izzie: That's not a dog. It's a hyena escaped from the zoo, and dressed in dog clothing.
Richard: Cranky nurses don't do us any good.
Izzie: (to Alex) Oh, well, maybe you can cheer them up.
George: ... well, then, why?
Bex: I'm as flat as a board. I took like five of those pills a day.
George: (looks confused)
Bex: Boobs, dude!
Derek: (to Addison) There is a land called Passive Agressiva, and you are their queen.
George: In high school I was secretary and treasurer of the Dungeons & Dragons club.
Bex: Oh man..
Episode Title: Begin the Begin
"Begin the Begin" is a reference to the song "Begin the Beguine" from the movie De-Lovely, sung by Sheryl Crow.
Or with a little broader prospective, it's a reference to the song "Begin the Beguine" written by Cole Porter (the subject of De-Lovely) and performed famously both Ella Fitzgerald and by Artie Shaw
Begin the Begin is also a song by R.E.M from the album Life's Rich Pageant.