We learn that Alex passed his medical board exams.

This episode did not include the opening credits sequence.

Meredith (voiceover): As doctors, we're trained to be sceptical, because patients lie to us all the time. The rule is, the patient is lying until proven honest. Lying is bad, and so we're told, constantly. Honesty is the best policy. The truth will set you free. I chopped down the cherry tree, whatever. (..) The fact is, lying is a necessity. (..) We lie to ourselves, because the truth... the truth freakin' hurts.

George: (to Meredith) I'm putting my foot down. Either the dog moves out or I do. Foot. Down. Now. Me or the dog, which is it?
(Meredith stares at the dog)
George: You hesitated. She hesitated!
Izzie: You hesitated?!

Patient's daughter: The nursing home says she never showed up. How exactly is that possible?
Nurse: She wouldn't leave.
Patient's daughter: My mother is old and infirm. You couldn't make her leave?
Nurse: Have you met your mother?

Bailey: (as she leaves in the elevator) I may be 47 months pregnant, I may be on bed rest, I may not be able to see my own feet, but I am Dr. Bailey. I hear everything. I know everything. I'm watching each and every one of you. And I will return.

Episode Title: Tell Me Sweet Little Lies

"Tell Me Sweet Little Lies" is part of a lyric from the song "Little Lies" by Fleetwood Mac.

George: Cujo has to go!

Cujo is a crazy, rabid dog from the book "Cujo", later made into a movie, by Stephen King.