This episode was nominated for the 2006 Emmy Award for Outstanding Prosthetic Makeup For A Series, Miniseries, Movie, or a Special.

Following the trend of "McLabeling", Dr. Mark Sloan is named "McSteamy" by the interns.

This is the first appearance of Jeff Perry (Thatcher Grey).

Cristina: What's wrong with you?
Meredith: My mommy's a filthy whore.

Izzie: (to Alex) You have dirty in your eyes.

Addison: Put the ice back on your hand.
Derek: My hand is fine.
Richard: Put the damn ice on your two-million-dollar-a-year-hand.

Dr. Mark Sloan: (to Meredith) You know, it's funny. Derek walks in on me naked with his wife, actually in the throes, then he just turns around and walks away. But he sees me as much as talking to you, and I'm on the ground bleeding. Interesting, don't you think?

Meredith: McSexy wants an x-ray to check for fractures.
Cristina: McSexy?
Meredith: No.
Izzie: McYummy.
Cristina & Meredith: No.
Meredith: McSteamy.
Cristina: Ah, there it is.
George: Now, I'll think I'll just be choking back some.. McVomit.

Izzie: You know, how when you don't have sex for a while, you sort of forget how good it is, and don't really need it as much?
George: Yeah, that doesn't happen to guys.
Izzie: It's like a beast. A beast that was asleep for a long long time, and now the beast is wide awake, and it wants to be fed. And the food that Alex gave it was.. good food, George.

Preston: I am Preston Burke. A widely-renowned cardio-thoracic surgeon. I am a professional, and more than that, I am a good and kind person. I am a person who cleans up behind himself, I am a person that cooks well, and you, you are an unbelievable slob, an angry intern. I am Preston Burke. And you are the most competitive, the most guarded, stubborn, most challenging person that I have ever met. And I love you. What the hell is the matter with you that you won't just let me?
Cristina: I gave up my apartment 20 minutes ago.
Preston: Well, all right then.

Meredith: (voiceover) I've heard that it's possible to grow up. I've just never met anyone who's actually done it.

Episode Title: Yesterday

Yesterday was composed by Paul McCartney (with writing partner John Lennon) and originally recorded by The Beatles. Since then, it has been performed by several bands and artists, including Bob Dylan, Ray Charles and Bad Religion.

Character Name: Dr. Mark Sloan

Eric Dane's character, Dr. Sloan, is the same name as Dick Van Dyke's character on the long running CBS drama, Diagnosis Murder.