Meredith (opening voiceover): First, do no harm. As doctors, we pledge to live by this oath. But harm happens and then guilt happens. And there is no oath for how to deal with that. Guilt never goes anywhere on its own, it brings its friends - doubt and insecurity.
Derek: The divorce is my fault, let me take responsibility.
Addison: We both had affairs.
Derek: You had a one night stand with Mark.
Addison: Derek, actually ... it was ... it was ...
Derek: It was two nights. You made a mistake. Meredith and I, we had a relationship.
George: I thought we were all done with the whole muffin thing.
Izzie: This isn't muffins. This is breakfast.
Meredith: Are you okay?
Izzie: Of course I’m okay. I’m a millionaire.
Derek: You look, uh, good without an appendix. It suits you.
Derek: Hey, you know what I like? I like that we're civilized. We're these adult grown people who can be divorced and friendly. We deserve a medal.
Addison: It wasn't a one night stand. Mark and I. It wasn't a one night stand, I was in love with him. Or at least I thought I was. After you left we lived together for two months. I wanted to believe that we could make it work, that I hadn't thrown my marriage away, that I hadn't thrown my life away on a fling. But he's Mark, and, well, I caught him with someone else, and then Richard called, so ... We both had relationships with other people. We're both equally liable for everything. So please, take the Brownstone.
Derek: All I want is Seattle. I want Seattle, and I want never to see you again.
Cristina: George, Alex, you guys go get the seats, Meredith and I'll get the snacks.
Izzie: Cristina's doing a running whip stitch on a heart.
Alex: I guess sleeping with your boss has it's perks.
George: This sucks! Cristina gets sex and perks.
Meredith: Maybe you should just apologize again, George.
George: Yeah, because you're in a great position to give relationship advice.
Izzie: Clearly, the doctor thing wasn't working for me. So go about your business, run labs, and cure cancer.
George: You're not going home. Either you hang out with us or we call your mother.
Meredith: She's just a few hours away and I'm sure she wouldn't mind coming and staying with you, all day.
Izzie: You wouldn't.
Izzie: Whoa, hey, hey! Okay, I'll just hang out in the locker room.
Meredith (closing voiceover): First do no harm, easier said than done. We can take all the oaths in the world, but the fact is, most of us do harm all the time. Sometimes even when we're trying to help, we do more harm than good. And then the guilt rears its ugly head. What you do with that guilt is up to you. We're left with a choice. Either let the guilt throw you back into the behaviour that got you into trouble in the first place, or learn from the guilt and do your best to move on.