Ratings: 21.0 million viewers

Meredith: (voiceover) To make it, really make it, as a surgeon it takes major commitment. We have to be willing to pick up that scalpel and make a cut that may or may not do more damage than good. It's all about being committed, because if we're not we have no business picking up that scalpel in the first place.

Meredith: (voiceover) There are times when even the best of us have trouble with commitment and we may be surprised at the commitments we're willing to let slip out of our grasp. Commitments are complicated. We may surprise ourselves by the commitments we're willing to make. True commitment takes effort and sacrifice. Which is why sometimes we have to learn the hard way to choose our commitments very carefully.

Nancy: And you have that thing for fairies.
Meredith and Derek: Ferry boats.

(in the elevator with Meredith; George is trying to be Cristina)
George: McDreamy was doing the McNasty with McHottie? That McBastard.

Meredith: What happened to the Callie's a corpse thing?
George: It was just one time.
Meredith: Then I get one too. Gin!

Nancy: I take it that was the slutty intern you cheated on Addision with?
Derek: She’s not slutty. What are you doing here?
Nancy: You bailed on Thanksgiving and Christmas, and you live in a trailer, and your getting a divorce. And then there’s the slutty intern.
Derek: I really don’t like you.
Nancy: You love me.

Derek: Dr. Stephens, Meredith, this is my sister Nancy.
Meredith: Sister?
Derek: Yeah.
Meredith: Oh, you’re one of Derek’s sisters.
Nancy: Um, yeah. Well, I knew you didn’t think I was the wife since you already ran her off.
Derek: Nancy is visiting from Connecticut. She’s on her way home now, straight back home.
Meredith: Well, it was nice to meet you.
Nancy: Okay.
Izzie: McDreamy’s sister is McBitchy.

Episode Title: Let The Angels Commit

"Let The Angels Commit" is the title of a song by Danielle Howle and the Tantrums.