Ratings: 10.5/19, #1 in its timeslot

This episode ran an additional 10 minutes, making it a 70 minute runtime instead of its typical 60 minute runtime.

Instead of the typical opening narration by Meredith, Cristina narrates the opening sequence. This also occured in "What Have I Done To Deserve This?" and "Deterioration of the Fight or Flight Response".

Cristina: It was both our idea, to rob the bank. It was both of us.
Meredith: I know.
Cristina: It’s just ... I couldn’t do it anymore. It wasn’t--
Meredith: You did the right thing.
Cristina: Yeah? And then how come I walked across the parking lot and realized that I couldn’t go home? But where am I supposed to go?

Bailey: I need all hands on deck.
Izzie: All hands. Does that mean all hands? (points to them) Or just all hands?
Bailey: Oh, Stevens … you shouldn’t have been paged. You can go and take over on Mr. O’Malley, he’s having surgery today with Dr. Burke.
Cristina: That’s my case. I’m with Burke.
Bailey: You have traumas rolling into the pit, she can take over for you.
Izzie: So I can scrub in? Thanks.
Bailey: Stevens, you will not scrub in. You will not handle any instruments. You will not move or talk or do anything other than breathe and watch.
Izzie: (sarcastically) Candy stripin’ again. No problem.

Dr. Hahn: Preston Burke. Back from the dead. Can't say the same for your patient.

Janelle: That’s pretty much a sign that I should have this baby, right? Even without a father.
Addison: Everyone has a father.
Mark: Not if she doesn’t tell him.
Janelle: You think I should tell him? Everyone says I’m wrong. He’s scum and now I’m the bad guy because I don’t want him in my kids life, right? That’s what you’re thinking?
Alex: My thing is, what about the kid? I mean, what happens when he’s six or seven and he wants to meet his dad?
Mark: Karev, that’s none of your business, okay?
Alex: She asked, okay?
Janelle: He cheated on me.
Alex: That makes him an ass. Doesn’t mean that you have to be one.

Izzie: (to Cristina) So are you and Meredith having one of your "we're best friends, we're so cool" secret time things? Sorry I'm cranky. Candy striping makes me so cranky.

Meredith: Don’t mention Cristina to Burke. It’s just not a good idea.
Derek: Yeah, well, what did you talk about this morning?
Meredith: Bank robberies. Which really isn’t the point because she was jogging and ... just cut her some slack today, okay? Not that I should interfere.
Derek: But you’re going to anyway.
Meredith: I'm just going to ask once. Very nicely. Please? (pause) Please? Please?
Derek: You know what says thank you like nothing else? Sex.
Meredith: I'm leaving now.

George: Hey. How's my dad?
Izzie: George, your ex is hardcore. Passionate, but hardcore.
George: Yeah, I know. How is my dad?
Izzie: Fine.
George: And my mom? Is she driving you crazy? Has she offered to iron your scrubs? She does that. She offers to iron things. Weird things.

Burke: Richard’s planning to retire. And he’s recommending that the board name me the next chief of surgery.

Cristina: (voiceover) In some ways, betrayal is inevitable. When our bodies betray us, surgery is often the key to recovery. When we betray each other, when we betray each other, the path to recovery is less clear. We do whatever it takes to rebuild the trust that was lost. And then there are some wounds, some betrayals … that are so deep, so profound that there is no way to repair what was lost. And when that happens, there's nothing left to do but wait.

Mark: I’d consider leaving that alone until she goes into the OR.
Janelle: Yeah about that, when’s that gonna happen because there’s a big shard of glass stuck in my heart, you know.
Alex: You’d be surprised how long people can live with stuff stuck inside their bodies -- glass, shrapnel, bullets.
Mark: I saw a guy once with half a chair leg in his chest, that was one hell of a splinter.
Janelle: Can we focus here?

During surgery, the blood-spatter pattern on her scrubs and goggles changes between shots.

In the ER, Meredith calls the patients time of death at 7:53, but moments later, Sloan's watch reads 10:00.

Episode Title: From a Whisper to a Scream

"From a Whisper to a Scream" is the title of a song by SoHo.

George: And my mom? Is she driving you crazy? Has she offered to iron your scrubs? She does that. She offers to iron things. Weird things.

George first made reference to his mother's tendency to iron everything in "The First Cut Is the Deepest".