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After George's father's heart operation, Mr. O'Malley heads back to the O.R. for another surgery for his cancer. As George continues to worry about his father, Meredith's father visits Seattle Grace in order to see his newborn granddaughter. Meanwhile, Meredith discovers that Derek is having trouble sleeping, which is no fault but her own. Elsewhere, the interns treat an angry 17 year-old girl with severe scoliosis who has a poor attitude towards the doctors due to the several surgeries she has endured during her life.
Ratings: 22.03 Million Viewers
Timeline: This episode was originally planned to be a one-part episode, but the plot line was later expanded into a two-part episode.
Music: "Love Will Come Through", the song that plays during the closing scene, was a song that was originally written for the film Moonlight Mile, which Grey's Anatomy star Ellen Pompeo starred in.
Trivia: This is the first episode to feature a "To Be Continued" ending.
Narration: This episode marks the second time that neither an opening or closing voiceover is featured.
Addison: This is Meredith Grey's niece. If I lost her, people might think I did it on purpose.
Meredith: So you're telling me that my snoring is so bad -- How did you deal with all those nights before I found out about your wife?
Izzie: He usually sleeps on the couch, sets and alarm, gets back into bed before you wake up.
Derek: Yeah, I didn't want to hurt your feelings.
Meredith: I'm going to do more than hurt your feelings.
Mark: Maybe you ought to head back to the gynie squad where everything is squishy and pink.
Heather: Well, there goes my theory that life doesn't suck for pretty people. I'm sorry I was such a bitch to you.
Izzie: Well, you're in pain. Sometimes I'm a bitch for no good reason at all.
Meredith: Are you watching me sleep?
Meredith: Are you some kind of weirdo who watch women sleep?
Dr. Webber: Who is presenting?
Mr. O'Malley: Can Georgie do it? He's real good.
George: Harold O'Malley, 63, status post aortic valve replacement. Morning chest X-ray showed no atelectasis after aggressive C.P.T. for the last 2 days. Scheduled for a transhiatal esophagectomy tomorrow morning at 9.
(The O'Malleys stare at George blankly)
George: That's it.
(The O'Malleys cheer)
Addison: Do you like abusing the interns? Is it fun for you?
Mark: Yes, it is, and in case you've forgotten, you don't get the high horse this week, Addison. Not this week.
Alex: He's an ass.
Addison: Not this week.
Callie: It's okay to be scared.
George: I'm not scared.
Callie: I'm just saying if you are, you can talk to me.
George: I'm not scared.
Callie: You sure about that?
George: Okay, now I'm scared of you.
Callie: Damn it. I was staring you down.
George: Staring me down?
Callie: Yeah, it worked on Shepherd.
Callie: Wait, let me try it again.
George: No, it's not. I'm still scared.
When Addison stops by Dr. Burke's room she takes off her glasses. The camera goes to Dr. Burke, then back to Addison, and she is taking off her glasses again.
When Derek is laying in George's bed, the blankets are covering his legs. In the next shot his feet and lower legs are completely visible.
Izzie is wearing the same clothes two days in a row, even though she changes into pyjamas at home in between.