Ratings: 22.9 million viewers; #1 in its timeslot

This episode was originally planned to be a one-part episode, but the plot line was later expanded into a two-part episode.

"Love Will Come Through", the song that plays during the closing scene, was a song that was originally written for the film Moonlight Mile, which Grey's Anatomy star Ellen Pompeo starred in.

This is the first episode to feature a "To Be Continued" ending.

This episode marks the second time that neither an opening or closing voiceover is featured.

(to Alex during the surgery)
Addison: This is Meredith Grey's niece. If I lost her, people might think I did it on purpose.

Meredith: So you're telling me that my snoring is so bad -- How did you deal with all those nights before I found out about your wife?
Izzie: (walking by the room) He usually sleeps on the couch, sets and alarm, gets back into bed before you wake up.
Derek: Yeah, I didn't want to hurt your feelings.
Meredith: I'm going to do more than hurt your feelings.
(Meredith hits him with a pillow)

Mark: (to Alex) Maybe you ought to head back to the gynie squad where everything is squishy and pink.

Heather: Well, there goes my theory that life doesn't suck for pretty people. I'm sorry I was such a bitch to you.
Izzie: Well, you're in pain. Sometimes I'm a bitch for no good reason at all.

Meredith: You’re watching me sleep again?
Derek: You’re cute when you sleep. What can I say?
Meredith: Yeah, but don’t you sleep? Why are you always up before the alarm?
Derek: I’m a light sleeper. It’s no big deal.
Meredith: So, something woke you up.
Derek: It’s no big deal. It’s just that ... you snore a little.
Meredith: What?! I do not.
Derek: Yes, you do. I love it. I find it charming that such a big noise can come from such a little person.
Meredith: You know what’s not charming?
Derek: What?
Meredith: Your morning breath.
Derek: I’m sorry. What?
Meredith: I’m just saying seeing how you’re always up before me, you might consider brush your teeth.

Meredith: Are you watching me sleep?
Derek: Maybe.
Meredith: Are you some kind of weirdo who watch women sleep?
Derek: Maybe.

Dr. Webber: Who is presenting?
Mr. O'Malley: Can Georgie do it? He's real good.
George: Harold O'Malley, 63, status post aortic valve replacement. Morning chest X-ray showed no atelectasis after aggressive C.P.T. for the last 2 days. Scheduled for a transhiatal esophagectomy tomorrow morning at 9.
(the O'Malleys stare at George blankly)
George: That's it.
(the O'Malleys cheer)

Addison: Do you like abusing the interns? Is it fun for you?
Mark: Yes, it is, and in case you've forgotten, you don't get the high horse this week, Addison. Not this week.
Alex: He's an ass.
Addison: Not this week.

Callie: It's okay to be scared.
George: I'm not scared.
Callie: I'm just saying if you are, you can talk to me.
George: I'm not scared.
Callie: You sure about that?
(Callie gives George "the stare")
George: Okay, now I'm scared of you.
Callie: Damn it. I was staring you down.
George: Staring me down?
Callie: Yeah, it worked on Shepherd.
George: Seriously?
Callie: Wait, let me try it again.
(Callie gives George "the stare" again)
George: No, it's not -- I'm still scared.

Episode Title: Six Days

"Six Days" is the title of a song by DJ Shadow.