Ratings: 24.1 million viewers

Meredith: (voiceover) As surgeons, we live in a world of worst-case scenarios. We cut ourselves off from hoping for the best because too many times, the best doesn't happen. But every now and then, something extraordinary occurs and suddenly best case scenarios seem possible. And every now and then, something amazing happens and against our better judgement we start to have hope.

Meredith: I'm not sure refusing treatment is what you want to do.
Ellis: Apparently what I want doesn't matter. It isn't even legally binding, so it's really about what you want Meredith. You're in charge.
Meredith: Do you think I like making these decisions for you? Do you think it's fun getting calls from the nursing home asking whether I was planing on giving the nurse who changes you every morning a Christmas tip? But I do it because you have managed to alienate everybody else in your life and I am the only one, so I have to step up and do it. You want to know why I'm so unfocused, so ordinary? You want to know what happened to me? You. You happened to me.
Ellis: Then let me refuse the heart surgery
Meredith: No!
Ellis: Why not?
Meredith: Because killing my mother is not going to be another thing that happens to me.

George: She's toxic. Her blood was toxic. It's not our marriage.
Callie: You thought our marriage was toxic?

(Burke and Derek pass out during the surgery; Cristina, Meredith, and Izzie are watching from the gallery)
Cristina: Well that's not good.

George: We got married in Vegas! We're married!
(the interns stare stunned)
Alex: Dude, she's Callie O'Malley.

Callie: You know those cartoons where there's a bear or whatever and it's starving. And it looks at a table and the table turns into this delicious cooked turkey with like lines of delciousness coming off it.
Addison: I was not looking at him like that because he is the help and I am not going to be sleeping with the help.
Callie: I married the help.
Addison: What?
Callie: We went to Vegas. My idea. I embrace the trashy.
Addison: That's -- not that I'm not happy for you. But why? Married -- so fast?
Callie: You know those cartoons where there's a bear and it's starving, and it looks at a cute intern.
Addison: Well, congratulations.
Callie: Thank you.

Episode Title: Wishin' and Hopin'

" Wishin' and Hopin'" is the title of a song that has been recorded by several artists including Dionne Warwick, Ani DiFranco and Dusty Springfield.