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With Izzie's inheritance money, Bailey and Izzie open the Seattle Grace free clinic and eagerly wait for their first patient. The lives of the doctors are put at risk when a patient's blood is found to be toxic. Meredith, Cristina and Izzie volunteer to risk their lives to save the woman after Derek and Burke's air-tight suits run out of battery. Meanwhile, Ellis, Meredith's Alzheimer's-stricken mother, has a change in her condition; George and Callie return to the hospital with surprising news; and Cristina gives Burke an answer to his proposal.
Ratings: 24.18 Million Viewers
Timeline: It has been 8 days since the previous episode, "Great Expectations", because Izzie says it took 8 days to build the Denny Duquette Memorial Clinic.
DVD: The season 3 DVD-box includes an audio commentary on this episode by Kate Burton and Ellen Pompeo.
Trivia: The toxic patient's storyline is based on a real story.
Meredith: (opening voiceover) As surgeons, we live in a world of worst-case scenarios. We cut ourselves off from hoping for the best because too many times, the best doesn't happen. But every now and then, something extraordinary occurs and suddenly best case scenarios seem possible. And every now and then, something amazing happens and against our better judgement we start to have hope.
George: She's toxic. Her blood was toxic. It's not our marriage.
Callie: You thought our marriage was toxic?
George: We got married in Vegas! We're married!
Alex: Dude, she's Callie O'Malley.
Callie: You know those cartoons where there's a bear or whatever and it's starving. And it looks at a table and the table turns into this delicious cooked turkey with like lines of delciousness coming off it.
Addison: I was not looking at him like that because he is the help and I am not going to be sleeping with the help.
Callie: I married the help.
Callie: We went to Vegas. My idea. I embrace the trashy.
Addison: That's -- not that I'm not happy for you. But why? Married -- so fast?
Callie: You know those cartoons where there's a bear and it's starving, and it looks at a cute intern.
Addison: Well, congratulations.
Callie: Thank you.
Cristina: I don't do rings. Don't expect me to suddenly change. I'm a surgeon, just like you. And we'll have money, we can hire a wife.
Burke: Are you saying yes?
Burke: I'm not letting you scrub in tomorrow.
Cristina: Well, I'm not wearing a ring.
Cristina: Okay then.
Meredith: She's charming, she's fabulous, and suddenly she's the enemy.
Derek: I'm meeting the enemy?
Meredith: Just don't get personal.
Derek: You're being ridiculous.
Meredith: I'm not being ridiculous.
Derek: Okay, it's gonna be fine.
Meredith: Just be careful. She has ways.
Izzie: What's going on?
Meredith: The chief figured out the anaesthesiologist didn't have time to drop an NG tube, so now they have to place one and decompress, and replace her intestines, and close, and they're about to run out of air.
Izzie: Holy crap. This so beats tampon training.
Meredith (closing voiceover): When the patient's body has failed them and all the science we have to offer has failed them, when the worst case scenario comes true, clinging to hope is all we've got left.