Meredith: (opening voiceover) As interns, we know what we want: to become surgeons. And we’ll do anything to get there. Suffer through killer exams, endure one hundred hour weeks, stand for hours on end in operating rooms. You name it, we’ll do it. The tough part is though, reconciling this huge thing we want, to be surgeons, with everything else we want.
Alex: So that's all? There's nothing more we can do? Am I overreacting?
Addison: I wish someone would care that much about my blood pressure.
George: What is the strongest layer in the small bowel?
Cristina: Fine, yummy.
Izzie: Damn it, damn it, damn it, damn it!
George: It is “not snot”.
Cristina: Wait wait wait wait. How do you know that? Are you studying with the wife’s cards?
Meredith: What cards?
Cristina: Callie was ranked number one in her year after this test. She has legendary flash cards.
Izzie: I don’t need the flash cards. We are independently brilliant.
George: Dream team.
Cristina: Yeah, I’m gonna hurl.
Meredith: Are we fine?
Meredith: Not convincing. I shouldn't have accused you of hovering. It wasn't nice. You were just trying to be there for me. But now I'm being available, and communicating, and getting naked, and doing all of your favorite things.
Derek: Good things.
Meredith: Then why are you still staring at the ceiling?
Derek: I don't ... I just ... that day you came out of the water ... trying to breathe for you. I love you, and I want you, but I don't know what to ... you didn't swim. You didn't swim and you know how to. And I don't know if I can ... I don't know if I want to keep trying to breathe for you.
Meredith: I should go. I'll go.
George: What’s your problem?
Izzie: My problem is you. You’re my penis fish.
George: Your what?
Izzie: You’ve crawled in and latched on, and now I can’t move, or talk, or think, or even pee without the nagging feeling that something is eating through my organs!
George: You don’t even have a penis. How am I the fish?
Izzie: It’s a metaphor, George.
George: What happened to us being fine?
Izzie: I don’t know. Maybe we’re not.
Mark: Twenty-eight more days and then it's you and me in a locked room for record breaking, earth shattering, mind blowing --
Addison: Okay, I got it. Thank you.
Mark: That was less than enthusiastic.
Addison: I'm gonna be more enthusiastic when we cross the finish line.
Mark: Okay, just making sure you haven't lost interest in the project.
Addison: Not at all.
Meredith: (closing voiceover) Too often, the thing you want most is the one thing you can't have. Desire leaves us heartbroken, it wears us out. Desire can wreck your life. But as tough as wanting something can be, the people who suffer the most are those who don't know what they want.