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As the interns study for and stress over their upcoming exam, the attendings suck up to the chairman of the board in order to become front runner for the Chief's position when he is admitted to the hospital as a patient. Meanwhile, Burke has a difficult time involving Cristina in the planning of their wedding, Addison and Alex get closer, and Derek begins to second guess his relationship with Meredith.

Episode Info

Episode number: 3x21
Production Number: 321
Airdate: Thursday April 26th, 2007

Director: Tom Verica
Writer: Mark Wilding

Alternate Airdates:

AU (Seven) Jul 22, 2007
DE (Pro7) Nov 07, 2007
FI (Nelonen) Jan 23, 2008
NL (Net 5) Jul 31, 2009


Guest Stars
Elizabeth ReaserElizabeth Reaser
As Jane Doe/Ava (Patient: Severe Injuries, Amnesia)
Kali RochaKali Rocha
As Dr. Sydney Heron (Surgical Resident)
Mitch PileggiMitch Pileggi
As Larry Jennings (Patient: Board Member, Candiru Fish)
Mary-Margaret HumesMary-Margaret Humes
As Nancy Jennings (Wife of Patient Larry Jennings)
Ramon De OcampoRamon De Ocampo
As James Benton (Patient: Brain Herniation)
Rowena KingRowena King
As Celeste Newman (Personal Assistant of Patient Larry Jennings)

Co-Guest Stars
Stewart SkeltonStewart Skelton
As Dr. Fischer (Resident Urologist)
Main Cast
Ellen PompeoEllen Pompeo
As Dr. Meredith Grey
Justin ChambersJustin Chambers
As Dr. Alex Karev
Patrick DempseyPatrick Dempsey
As Dr. Derek Shepherd
Chandra WilsonChandra Wilson
As Dr. Miranda Bailey
James Pickens, Jr.James Pickens, Jr.
As Dr. Richard Webber
Sara RamirezSara Ramirez
As Dr. Calliope "Callie" Torres
Eric DaneEric Dane
As Dr. Mark Sloan
Kate WalshKate Walsh
As Dr. Addison Montgomery-Shepherd
T.R. KnightT.R. Knight
As Dr. George O'Malley
Sandra OhSandra Oh
As Dr. Cristina Yang
Isaiah WashingtonIsaiah Washington
As Dr. Preston Burke
Katherine HeiglKatherine Heigl
As Dr. Isobel "Izzie" Stevens
Episode Notes
Ratings: 20.08 Million Viewers

DVD: The season 3 extended DVD-box includes an audio commentary on this episode by Sandra Oh.

ArtistSong TitlePlayed When
Anna WaronkerHow Am I DoingMeredith and Derek Talking in Bed, Closing Scenes
BeckNauseaCallie Exits, Izzie Now Alone in Elevator, Surgery
The Bird and the BeeAgain & AgainPatient’s Assistant Goes to Move Car, Lunch Scene
Let’s Go SailingBetter OffBurke Exits, Callie and Addison Talk, Ava Listens
The ReddmenThe Secrets of Amanda PrinesOpening Scenes, Seattle, Interns Studying Together

Episode Quotes
Meredith: (opening voiceover) As interns, we know what we want: to become surgeons. And we’ll do anything to get there. Suffer through killer exams, endure one hundred hour weeks, stand for hours on end in operating rooms. You name it, we’ll do it. The tough part is though, reconciling this huge thing we want, to be surgeons, with everything else we want.

Alex: So that's all? There's nothing more we can do? Am I overreacting?
Addison: I wish someone would care that much about my blood pressure.

George: What is the strongest layer in the small bowel?
Cristina: Fine, yummy.
Izzie: Damn it, damn it, damn it, damn it!
George: It is “not snot”.
Izzie: Submucosa!
George: Yes!
Cristina: Wait wait wait wait. How do you know that? Are you studying with the wife’s cards?
Meredith: What cards?
Cristina: Callie was ranked number one in her year after this test. She has legendary flash cards.
Izzie: I don’t need the flash cards. We are independently brilliant.
George: Dream team.
Cristina: Yeah, I’m gonna hurl.

Meredith: Are we fine?
Derek: Sure.
Meredith: Not convincing. I shouldn't have accused you of hovering. It wasn't nice. You were just trying to be there for me. But now I'm being available, and communicating, and getting naked, and doing all of your favorite things.
Derek: Good things.
Meredith: Then why are you still staring at the ceiling?
Derek: I don't ... I just ... that day you came out of the water ... trying to breathe for you. I love you, and I want you, but I don't know what to ... you didn't swim. You didn't swim and you know how to. And I don't know if I can ... I don't know if I want to keep trying to breathe for you.
Meredith: I should go. I'll go.

George: What’s your problem?
Izzie: My problem is you. You’re my penis fish.
George: Your what?
Izzie: You’ve crawled in and latched on, and now I can’t move, or talk, or think, or even pee without the nagging feeling that something is eating through my organs!
George: You don’t even have a penis. How am I the fish?
Izzie: It’s a metaphor, George.
George: What happened to us being fine?
Izzie: I don’t know. Maybe we’re not.

Mark: Twenty-eight more days and then it's you and me in a locked room for record breaking, earth shattering, mind blowing --
Addison: Okay, I got it. Thank you.
Mark: That was less than enthusiastic.
Addison: I'm gonna be more enthusiastic when we cross the finish line.
Mark: Okay, just making sure you haven't lost interest in the project.
Addison: Not at all.
Mark: Good.

Meredith: (closing voiceover) Too often, the thing you want most is the one thing you can't have. Desire leaves us heartbroken, it wears us out. Desire can wreck your life. But as tough as wanting something can be, the people who suffer the most are those who don't know what they want.

Episode Goofs
Editing Error:

When Addison is inspecting the wedding cakes, we hear her say, "White chocolate with vanilla butter-cream..." but her mouth does not move at all.

Cultural References
Episode Title: Desire

Desire is the title of a song originally sung by U2.

Episode References
Season 3, Episode 18: George and Izzie slept together at the end of 3x18 "Scars and Souvenirs" after getting drunk.

Season 3, Episode 17: Addison and Mark made a pact in 3x17 "Some Kind of Miracle" that they would not sleep with anyone for a whole month.

Season 2, Episode 27: Addison asks Alex if she has "another Denny Duquette situation on my hands?" She is referring to the relationship between Izzie Stevens and her patient Denny Duquette before his death in 2x27 "Losing My Religion".

Other Episode Crew

CreatorShonda Rhimes
Co-ProducerZoanne Clack
Associate ProducerLisa Taylor (1)
CastingJohn Brace (1)  |  Linda Lowy
Unit Production ManagerJeff Rafner
First Assistant DirectorAnnette Sutera
Second Assistant DirectorShawn Hanley
MusicDanny Lux
Costume DesignerMimi Melgaard
HairstylistSean Flanigan
Key GripRussell Nordstedt
Set DecoratorKaren Bruck
Location ManagerGeorge Larson
Transportation CoordinatorTom Gilhooley
Property MasterAngela Whiting
Construction CoordinatorCurt Jones
Production Sound MixerScott D. Stolz
Script SupervisorDiane Collins
Production CoordinatorSue Jennings
Assistant EditorJoe Mitacek
Post Production CoordinatorMichelle Hall
Sound MixerDon Digirolamo  |  Todd Langer
Special EffectsJason Gustafson
Executive Story EditorStacy McKee
Costume SupervisorTom Houchins
Special Makeup Effects ArtistBari Dreiband-Burman  |  Thomas R. Burman
Production AccountantJon Cohoe
Chief Lighting TechnicianPeyton Skelton
Sound SupervisorTom Davis (1)
ResearcherElizabeth Klaviter
Department Head Make-upNorman Leavitt (1)
Production StaffMeg Marinis  |  Chris Van Dusen  |  Sonay Washington  |  Darren Preston Lane  |  Eric Buchman  |  Jim Campolongo
Theme Song Written And Performed ByPsapp
Medical ConsultantKaren Lisa Pike
Medical ProducerLinda Klein
Film LabA Fotokem Company
Media Talent CoordinatorKarin Gleason
Missing Information
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