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Izzie reveals her true feelings for George to one of her and George's friends, and the reaction she receives is not what she expected. Meanwhile, Adele Webber rushes her niece to Seattle Grace; Derek gives Cristina pointers on how to be a better teaching resident; and Norman, the world's oldest intern, misdiagnoses Meredith's patient.
Episode Info
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Episode number: 4x4 Production Number: 404 Airdate: Thursday October 18th, 2007 Alternate Airdates:
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FI (
NL (
UK (
Co-Guest Stars
Main Cast
Episode Notes
In previous episodes that the character of Camille appeared, she was played by Tessa Thompsson. In this episode Camille Winbush takes over the role.
Music
| Artist | Song Title | Played When |
| John Legend | Sun Comes Up | Derek Tells Meredith How He Feels, Closing Scenes |
| Kim Richey | The Absence Of Your Company | Webber's Niece Talks About Her Cancer |
| Meiko | Hawaii | Webber's Niece Talks More About Her Cancer to Him |
| Northern State | Better Already | Opening Scenes, Callie Gives a Surprising Response |
| Prince Fatty | Milk and Honey (featuring Hollie Cook) | Izzie Walks Off, Lexie Talks to Derek and Cristina |
| Yeah Yeah Yeahs | Rockers To Swallow | Callie Meets Up with Izzie in the Cafeteria |
Episode Quotes
Meredith: (voiceover) In life only one thing is certain, apart from death and taxes: No matter how hard you try, no matter how good your intentions, you are going to make mistake. You are going to hurt people. You are going to get hurt. And if you ever want to recover, there's really only one thing you can say.
Meredith: (to Derek) Not-couples have no reason to go away together.
George: Callie ... you haven't said anything and ... just say something ... please, anything.
Callie: I forgive you.
George: What?
Callie: You made a mistake, but we took vows, "'til death do we part," so ... I forgive you.
Callie: I forgive you.
George: What?
Callie: You made a mistake, but we took vows, "'til death do we part," so ... I forgive you.
Izzie: Callie! Hey. Hi.
Callie: We have to talk.
Izzie: Okay. Um, about?
Callie: George told me.
Izzie: He told you.
Callie: Everything. Cafeteria. Noon. You and me. Be there.
Callie: We have to talk.
Izzie: Okay. Um, about?
Callie: George told me.
Izzie: He told you.
Callie: Everything. Cafeteria. Noon. You and me. Be there.
Izzie: No, she's saving all her rage and bloodshed for me. And she's gonna kill me in the cafeteria at lunch.
George: No, she wouldn't.
Izzie: She breaks bones for a living George! She's crazy!
George: No, she's not crazy.
Izzie: Well, she is if she thinks I'm not gonna put up a fight.
George: No, she wouldn't.
Izzie: She breaks bones for a living George! She's crazy!
George: No, she's not crazy.
Izzie: Well, she is if she thinks I'm not gonna put up a fight.
Bailey: People are stupid and just want to be loved. That's the only reason anyone does anything.
Cristina: (to Izzie) You were very ghettofabulous.
Lexie: I just wanted to say thank you for saving my ass in surgery today.
Cristina: That's my job, 3.
Cristina: That's my job, 3.
Cultural References
Episode Title: The Heart of the Matter
"The Heart of the Matter" is the title of a song by both Don Henley and India Arie.
"The Heart of the Matter" is the title of a song by both Don Henley and India Arie.
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