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Grey's Anatomy
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| Title: | The Heart Of The Matter |
| Episode Number: | 65 |
| Season: | 4 |
| Season Episode #.: | 4 |
| Production Number: | 404 |
| Original Airdate: | Thursday October 18th, 2007 |
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| | Other Release Dates: (Edit) | | Country: | Aired On: | |
 Netherlands |
Aug 18, 2008 |
 United Kingdom |
Oct 02, 2008 |
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Izzie reveals her true feelings for George to one of her and George's friends, and the reaction she receives is not what she expected. Meanwhile, Adele Webber rushes her niece to Seattle Grace; Derek gives Cristina pointers on how to be a better teaching resident; and Norman, the world's oldest intern, misdiagnoses Meredith's patient.
| There are no foreign summaries for this episode
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| In previous episodes that the character of Camille appeared, she was played by Tessa Thompsson. In this episode Camille Winbush takes over the role.
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| | Artist | Song Title | Played When | | •John Legend | Sun Comes Up | | | •Kim Richey | The Absence Of Your Company | | | •Meiko | Hawaii | | | •Northern State | Better Already | | | •Prince Fatty | Milk And Honey | | | •Yeah Yeah Yeahs | Rockers To Swallow | |
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| Meredith: (voiceover) In life only one thing is certain, apart from death and taxes: No matter how hard you try, no matter how good your intentions, you are going to make mistake. You are going to hurt people. You are going to get hurt. And if you ever want to recover, there's really only one thing you can say.
| Meredith: (to Derek) Not-couples have no reason to go away together.
| George: Callie ... you haven't said anything and ... just say something ... please, anything.
Callie: I forgive you.
George: What?
Callie: You made a mistake, but we took vows, "'til death do we part," so ... I forgive you.
| Izzie: Callie! Hey. Hi.
Callie: We have to talk.
Izzie: Okay. Um, about?
Callie: George told me.
Izzie: He told you.
Callie: Everything. Cafeteria. Noon. You and me. Be there.
| Izzie: No, she's saving all her rage and bloodshed for me. And she's gonna kill me in the cafeteria at lunch.
George: No, she wouldn't.
Izzie: She breaks bones for a living George! She's crazy!
George: No, she's not crazy.
Izzie: Well, she is if she thinks I'm not gonna put up a fight.
| Bailey: People are stupid and just want to be loved. That's the only reason anyone does anything.
| Cristina: (to Izzie) You were very ghettofabulous.
| Lexie: I just wanted to say thank you for saving my ass in surgery today.
Cristina: That's my job, 3.
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| Episode Title: The Heart of the Matter
"The Heart of the Matter" is the title of a song by both Don Henley and India.Arie.
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