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Grey's Anatomy: Physical Attraction... Chemical Reaction

George and Izzie's relationship is tested, as is Derek and Meredith's when Derek wants more than a physical relationship with her. Meanwhile, Mark falls for a surgeon and Callie's position as Chief Resident is put on the line when she gives too many duties to Bailey.

Episode Info

Episode number: 4x7
Production Number: 407
Airdate: Thursday November 08th, 2007

Alternate Airdates:

FI (Nelonen) Apr 09, 2008
NL (Net 5) Sep 08, 2008
UK (sky LIVING) Oct 23, 2008


Guest Stars
Jeff PerryJeff Perry
As Thatcher Grey (Father of Dr. Meredith Grey)
David Burke (1)David Burke (1)
As Don (Father of Patient Brian)
Enuka OkumaEnuka Okuma
As Teresa Brotherton (Patient: Hemothorax, Mother Who Brought In Baby)
Kurt FullerKurt Fuller
As Jerry (Patient: Bowel Resection)
Rockmond DunbarRockmond Dunbar
As Sean Brotherton (Husband of Patient Teresa Brotherton)
Stephanie MarchStephanie March
As Jane (Mother of Patient Brian)
Vicki LewisVicki Lewis
As Harriet (Patient: Face Lift)

Co-Guest Stars
Amrapali AmbegaokarAmrapali Ambegaokar
As Intern Dani
Linda Eve MillerLinda Eve Miller
As ER Nurse
Mark SaulMark Saul
As Intern Steve
Braeden Le MastersBraeden Le Masters
As Brian (Patient: Swallowed Marbles)
Main Cast
Ellen PompeoEllen Pompeo
As Dr. Meredith Grey
Justin ChambersJustin Chambers
As Dr. Alex Karev
Patrick DempseyPatrick Dempsey
As Dr. Derek Shepherd
Chandra WilsonChandra Wilson
As Dr. Miranda Bailey
James Pickens, Jr.James Pickens, Jr.
As Dr. Richard Webber
Sara RamirezSara Ramirez
As Dr. Calliope "Callie" Torres
Brooke SmithBrooke Smith
As Dr. Erica Hahn
Chyler LeighChyler Leigh
As Dr. Lexie Grey
Eric DaneEric Dane
As Dr. Mark Sloan
T.R. KnightT.R. Knight
As Dr. George O'Malley
Sandra OhSandra Oh
As Dr. Cristina Yang
Katherine HeiglKatherine Heigl
As Dr. Isobel "Izzie" Stevens
Episode Notes
Ratings: 19.50 Million Viewers

Trivia: Guest star Enuka Okuma is now one of the stars of Canadian cop drama Rookie Blue.

ArtistSong TitlePlayed When
CalahanPouring on the GasolineBar Scene, Lexie Talking to Joe, Mark Hits on Hahn
Derek WebbNameOpening Scenes, Seattle, Izzie and George in Bed
Joe PurdySan JoseMeredith Exits, Lexie Contemplates, Hahn's Surgery
Northern StateiloveitwhenyaBailey Opens the O.R. Door, Callie Operating
Priscilla AhnRainMeredith Talks to Alex About Lexie, Closing Scenes

Episode Quotes
Meredith: (opening voiceover) Before we were doctors, we were med students, which meant we spend a lot of time studying chemistry. Organic chemistry, biochemistry. We learned it all. But when you are talking about human chemistry, only one thing matters -- either you've got it or you don’t.

Derek: What's new with you?
Meredith: I saw my half-sister half naked.

Cristina: I am painting Burke's apartment so I can stop calling it Burke's apartment. A happy color. Red. Like blood.

Izzie: I love George. Oh, God I do, I love him, and I'm so happy because he's kind and smart and um, sweet and sexy. He's perfect, perfect, except for the fact that he kisses like a chicken. You know a chicken pecking the ground for food, justs pecking and pecking and pecking, and when he's pecking at me like that I forget that I love him, I forget that he's kind and sweet and sexy and I just wanna scream, "Stop pecking at me!" Did he peck you like a chicken, Mer?

Derek: Oh, I'm late. Dropped off the Chief's dry cleaning.
Mark: You're doing his laundry?
Derek: I'm helping out.
Mark: Yeah, what's he doing?
Derek: He has an extensive DVD collection.
Mark: You're dating the Chief. Huh.

George: Hey.
Meredith: You look weird.
George: I don't look weird.
Meredith: What's wrong?
George: I look fine.
Meredith: I know you.
George: It's horrible. The sex. With Izzie... horrible. It's like she's trying to hard it's...you ever seen a porno? Not that Izzie's a porno; she's an angel, but it's like she's trying to...channel a porn star and she's trying to act all dirty and sexy, which sounds great, right? But in reality I just wanna say, "Izzie, just because you can do that with your legs doesn't mean that you should."
Meredith: Uh...I wanna run.
George: Run, run. Run now!

George: You know, he did this so his parents will get a divorce. He made himself sick so that they would take hi seriously.
Bailey: Mmm. I bet they take him seriously now.
George: Nah. They just said that they would try not to fight as much.
Bailey: I am elbow deep in their eight year-old. Sounds like somethin' a little extra effort can't fix.
George: You're probably right.
Bailey: I am so right. About so many things, it'll make your head spin.

Meredith: (closing voiceover) Chemistry, either you've got it. Or you don't.

Episode Goofs
Factual Error:

When Bailey is performing surgery on Brian she says that there are "seven magnets in the tray" and she needs to find one more (because George says he swallowed eight). However, George only discovered that they were magnets when Ryan spat up a cluster of them. Brian could not have swallowed eight, spat five up, and still have eight in his body.

Factual Error:

Sloan's face lift patient is able to talk and move their face freely after surgery. Usually a face lift patient is too sore to move their face so much for days and weeks afterwards.

Factual Error:

When Bailey is pulling the magnets out of the boy during surgery they are not sticking together in the surgical tray like should be. They are magnetic and should be stuck to one another and to the metal of the tray.


When Izzie goes to check on her post-op patient Harriet, her hair changes between a loose bun and a ponytail with a headband several times.


Cristina can be heard saying "Get me a crash car, she's not breathing," during the Grey's Anatomy title sequence. However, before the screen fades to the title you can see there is already a crash cart there.


When George's patient returns to the clinic claiming to have eaten 8 more marbles, they fall through his armpit and not his mouth as he bends over to regurgitate them.

Cultural References
Episode Title: Physical Attraction, Chemical Reaction

"Physical Attraction, Chemical Reaction" is the title of a song by Madonna.

The Godfather: Richard Webber quotes a line to Derek, saying "I am going to make him an offer he can't refuse."

This is a very famous line from the 1972 film The Godfather.

Episode References
Season 4, Episode 6: Meredith tells Derek that she saw Lexie half naked. At the end of 4x06 "Kung Fu Fighting" Meredith saw Alex and Lexie together at her house.

Season 3, Episode 24: This is the first appearance of Meredith's father, Thatcher Grey, since 3x24 "Testing 1-2-3".

Missing Information
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