This was the final episode of Grey's Anatomy completed before the 2007 WGA writers' strike.

Bailey: (opening voiceover) In the beginning, God created the Heaven and the Earth, at least that's what they say. He created the birds of the air and the beasts of the field and He looked at his creation and he saw that it was good. And then God created man. And it's been downhill ever since. The story goes on to say that God created man in His own image, but there's not much proof of that. After all, God made the sun and the moon and the stars and all man makes is trouble. And when man finds himself in trouble, which is most of the time, he turns to something bigger than himself, to love, or faith or religion, to make sense of it all. But for all surgeons, the only thing that makes any kind of sense is medicine.

Lexie: Where's your girlfriend?
Alex: Back with her husband, I'm guessing. And I don't have a girlfriend.
Lexie: Or a conscience, apparently.

Bailey: (closing voiceover) As doctors, we know more about the human body now than at any point in our history. But the miracle of life itself, why people live and die, why they hurt or get hurt is still a mystery. We wanna know the reason, the secret, the answer at the back of the book, because the thought of our being all alone down here is just too much for us to bear. But at the end of the day, the fact that we show up for each other, in spite our differences, no matter what we believe, is reason enough to keep believing.

In "Crash Into Me", Alex is suspended for two weeks. However, Alex is working in this episode, which is said to take place only one day later.

Episode Title: Lay Your Hands On Me

"Lay Your Hands On Me" is the title of a song by Bon Jovi.