Dr. Wyatt: We had our first honest conversation about your feelings, and now you want to leave. That timing doesn’t strike you as strange?
Meredith: No, and I’m still firing you.
Dr. Wyatt: No, you’re quitting
Meredith: No, I’m not quitting. I don’t quit things
Dr. Wyatt: No, actually you do. Your mother quit your father. Your father quit you. You quit your boyfriend and if I read your hospital chart correctly you quit your life momentarily on a couple of occasions. You quit. It’s what you know how to do.
Meredith: Now you’re really fired.

Meredith: We’ve got this patient and she’s got true love. You want to know why? Because her boyfriend doesn’t exist. Derek is all broken up over her like it means something that she’s having an affair with a hallucination.
Dr. Wyatt: But Derek wasn’t ready to give up on the relationship when you were.
Meredith: No, I didn’t give up. I wanted to try again, and then he went a kissed Rose. So he’s the one that messes up, not me.
Dr. Wyatt: But it’s a relationship. People make mistakes, and you stand back waiting for him to fail so you can say AHA! Now I quit.
Meredith: No, it wasn’t working
Dr. Wyatt: Was your life not working when you let that slip out from under you?
Meredith: When are you going to stop suggesting that I’m suicidal?
Dr. Wyatt: When you start acting like someone that wants to be alive.
Meredith: Give me my chart.
Dr. Wyatt: Why?
Meredith: Because I’m not suicidal, and if it says that I am, then it’s wrong.
Dr. Wyatt: What happened last year when you fell in the water?
Meredith: I almost drowned. Do you think I did that for kicks?
Dr. Wyatt: You put your hand in a body cavity that contained unexploded ammunition.
Meredith: I was trying to save a patient!
Dr. Wyatt: Why is it that every other person in that room had the sense to hit the deck? You know people run away from this line between life and death. You seem to stand on it and wait for a strong wind to sway you one way or the other. You’re careless with your life. You’re not slitting your wrists but you’re careless. Probably because your mother told you you were a waste of space on this planet. The problem is you believed her. And if you don’t want out one of these days you’re going to die because of it.
Meredith: Hand me my chart. Now! And don't ever talk about my mother again.

Meredith: Cristina, are you in the dark place?
Cristina: Yeah.
Meredith: Me too.

George: He punched someone named Harrison.
Bailey: (to Tucker) You punched a child?
George: Apparently there was a graham cracker involved.
Bailey: Over a graham cracker?
George: They said they want you to talk to him.
Bailey: What, he's 14 months old? What do they think I'm going to do, give him a lecture on non-violent conflict resolution?
George: I really don't know.
Bailey: My son punches other children!

Lexie: I forgive you.
Meredith: Lexie.
Lexie: No. I forgive you. I forgive you for treating me like crap, and I forgive you for letting your friend treat me like crap.
Meredith: Lexie.
Lexie: I don't know how you get up in the morning, I honestly don't. Our dad abandoned you. And your mom by all accounts was the meanest person ever and you can't let Derek love you and it all really, really sucks. But ever since I knew you existed I had this fantasy about my big sister and you have failed, on every occasion to live up to that fantasy. But I still love you, whether you are capable of letting me or not. So, I forgive you. (storms out of the bathroom)
Dr. Wyatt: (coming out of the bathroom stall) Two o'clock work for you?
Meredith: Yeah, okay.

Chief: We need to write Adele again. She replied to my email but all she sent was a typo. She's no better at this than I am.
George: That's not a typo sir, that's a wink.
Chief: Well that's a semi-colon and a closed parenthesis.
George: Turn it sideways.
Chief: Well, what the hell does this mean?
George: She's flirting, sir.
Chief: Oh, oh, that's good!

Meredith: (voiceover) Don't wonder why people go crazy. Wonder why they don't. In face of what we can lose in a day, in an instant, wonder what the hell it is that make us hold it together.

Episode Title: Losing My Mind

"Losing My Mind" is the title of a song by Maroon 5.

Dr. Wyatt: What happened last year when you fell in the water?
Meredith: I almost drowned. Do you think I did that for kicks?

Dr. Wyatt is referencing "Drowning on Dry Land (2)" and "Some Kind of Miracle (3)" in which during a ferry accident, Meredith falls into the water and nearly drowns. In the latter episode, Meredith has to be shocked several times in order to be brought back to life.

Dr. Wyatt: You put your hand in a body cavity that contained unexploded ammunition.
Meredith: I was trying to save a patient!

Dr. Wyatt is referencing "It's the End of the World (1)" and "(As We Know It) (2)" in which Meredith holds a grenade that was lodged inside of a patient in order to keep it from exploding.