Meredith (opening voiceover): Okay. Anyone who says you can sleep when you die... Tell them to come talk to me after a few months as an intern. Of course it's not just the job that keeps us up all night. I mean if life's so hard already, why do we bring so much trouble on ourselves. What's up with the need to hit the self-destruct button?
Meeredith: Yikes, wouldn't want to meet you in a dark alley.
Cristina: Right back at 'ya. (Alex jogs up)
Izzie: A run? You run?
Alex: Every day, babe, every day.
Meredith: Not suffering enough?
Alex: What doesn't kill you, makes you stronger.
Cristina: Don't go acting all indefatigable. You're dragging like the rest of us.
Alex: Oh, what is that, professional weakness, Dr. Yang?
Cristina: It's called the flu.
Izzie: If you wait a few minutes you can have a piece of cake, baked chock full of love. Actually chock full of unrelenting, all-consuming rage and hostility, but still tasty.
Meredith: Why do I keep hitting myself with a hammer? Because it feels so good when I stop.
Meredith: I hate you! (takes a slice of cake from Izzie) And your cake!
Izzie: No, no, the cake is good.
Burke (taking the X-ray and showing it to Bailey walking by): You remember this guy?
Bailey: Hey, the tattooed masochist.
Burke: Had himself shot again.
Bailey: Glad to see he's still stupid.
Meredith: Thought you'd be asleep by now.
Izzie: Yeah, well ... I'm not. (pause) If you wait a few minutes, you can have a piece of cake. Baked it chock full of love. Actually, chock full of unrelenting, all-consuming rage and hostility, but -- still tasty.
Meredith: So you know?
Izzie: I know.
Meredith: Well, do you want the long, sordid version, or do you want the short version where I started sleeping with a guy who turned out to be my boss?
Meredith: Izzie, cut me some slack here.
Izzie: No! You went to Dartmouth. Your mother is Ellis Grey. You grew up -- look at this house! You know, you walk into the OR, and there isn't anyone who doubts that you should be there. I grew up in a trailer park. I went to state school. I put myself through med school by posing in my underwear. You know, I walk into the OR, and everyone hopes I'm the nurse. You-you have their respect without even trying, and you're throwing it away for ... what? A few good surgeries?
Meredith: No, it's not about the surgeries, it's not about getting ahead.
Izzie: Then what, a little hot sex? You're willing to ruin your credibility over that? I mean Meredith, what the hell are you doing? (Meredith rolls her eyes) Oh my god... you're falling for him.
Meredith: I am not.
Izzie: Oh you so are.
Meredith: No, I'm not.
Izzie: So are... Dammit. You poor girl.
George: I'm sorry, but did you just.....have you been drinking?
Dr. Taylor: I beg your pardon?
George: Do you smell.....? I smell alcohol.
Dr. Taylor: Where the hell do you get off accusing me of something like that?
Derek: George, you're out of line.
George: There are rules. You know, there are rules for a reason. There is a 2-year-old girl on this table! You shouldn't take advantage of someone else's vulnerability.
Dr. Taylor: I don't need some punk intern telling me what's at stake here. (to Derek) Get him out of here, Shep. Shep?
Derek: You're out, George.
Meredith (closing voiceover): Maybe we like the pain. Maybe we're wired that way. Because without it, I don't know, maybe we just wouldn't feel real. What's that saying? Why do I keep hitting myself with a hammer? Because it feels so good when I stop.
When Izzie leaves the house, she has a purple travel coffee mug. When she gets out of the car, it is a disposable mug, but when she leaves the locker room, she is holding the purple mug again.
When Jamie is being examined by George you can tell that the shot of her legs twitching are not the same legs as the original little girl. In the shot of her leg twitching he has no shirt on. In the next, she is wearing a shirt.
Izzie is surprised to discover that Derek and Meredith are sleeping together. She should already know about their relationship because she was there when Cristina yelled at Meredith about it in the pilot episode.
Claire's parents should know about the scars on her abdomen because they told Meredith that she had collapsed in the shower. Unless she showers fully clothes, they should have seen the scars.