Ratings: 19.5 million viewers
Trivia: Throughout this season, ABC started a website which ran segments explaining the science behind each patient's cases in layman's terms.
Timeline: This episode and the next three episodes were originally a part of the first season.
Casting: Kate Walsh (Dr. Addison Shepherd) and Sandra Oh (Dr. Cristina Yang) previously worked together in the 2003 film Under the Tuscan Sun.
Rankings: This season ranked #5 overall in the 2005-06 TV season Nielsen ranking and averaged 19.44 million viewers. This average is an increase in 2 million viewers from the previous season and the overall ranking increased by 5 as compared to the first season.
Meredith (opening voiceover): To be a good surgeon you have to think like a surgeon. Emotions are messy. Tuck them neatly away and step into a clean sterile room where the procedure is simple. Cut, suture, and close. But sometimes you're faced with a cut that won't heal. A cut that rips its stitches wide open.
George: Oh, so you and Joe?
Bailey: All you people ever think about is how to get into somebody's pants. You nasty. That's why you got syphilis.
Meredith: And you met me.
Derek: And I met you.
Meredith: What was I to you? The girl you screwed to get over being screwed?
Derek: You were like coming up for fresh air. It's like I was drowning and you saved me. That's all I know.
Meredith: It's not enough.
Cristina: You realize this constitutes hugging?
Meredith: Shut up...I'm your person.
Meredith: You're sleeping with someone?
George: What? Who?
Cristina: Why is that such a shock? Even George managed to get some action.
George: Correction, George got some syph.
Cristina: You know what happens to pregnant interns. I'm not switching to vagina squad or spending my life popping zits. I'm too talented, surgery's my life.
Meredith: Let's play a game of whose life sucks the most. I'll win. I always win.
Christina: We weren't in a relationship!
Meredith: So you were in -
Christina: Switzerland. It's very nice there and they make great watches.
Meredith: I am this close to getting in my car and running you down in the parking lot.
Meredith: Derek is married, as in pig-headed adulterous liar married.
Alex: Oh, sure, I'm the guy with the heart of stone, and you brought snacks.
Izzie: It's a working lunch.
Alex: Snacks to watch Joe die.
Izzie: He's not gonna die die, they're gonna bring him back.
Alex: He's gonna die die, no pulse pulse, he is gonna be dead dead.
Burke: What do you want?
Burke: You don't want to go out to dinner, you don't want to meet me in the on-call room and you sure as hell don't want to talk to me. I could pretend I know, but hey, I don't even have your home phone number. So tell me - what do you want?
Cristina: Don't yell at me. (Burke walks away) Wait. Hey, we're havin' a conversation here.
Burke: Well, what do you want?
Cristina: I don't know. (he grabs her and kiss her, hard)
Burke: Well, figure it out.
Meredith (closing voiceover): They say that practice makes perfect. Theory is– the more you think like a surgeon, the more you become like one, the better you get at remaining neutral, clinical, cut, suture, close - the harder it becomes to turn it off. To stop thinking like a surgeon, and remember what it means to think like a human being.