Meredith (opening voiceover): My aunt would say, "say when", and of course, we never did. We don't say when because there is something about the possibility of more... more tequila... more love... more anything... because more is better.
Meredith: (to Derek) I am a sink with an open drain. Anything you say runs straight out.
George: She probably could have picked a better metaphor.
Izzie: Give her a break, she's got a hangover.
Cristina: The problem is estrogen.
Meredith: No, the problem is tequila.
Derek: (to Addison) I'm a sink with an open drain, honey.
Meredith: (to George) What are you doing with Olivia? You're letting her think you're emotionally available. You're letting her think she has a chance. And there is nothing worse in the world than thinking you have a chance when you really don't.
Addison: We got succesful, you and me. We got busy and we got lazy. We didn't even bother to fight anymore, Derek, and Mark was there and I missed you and now I'm sorry. I'm more sorry than you could possibly imagine, but at least I'm talking to you about it.
George: So you really broke up with Shepard?
Meredith: I feel empty.
Izzie: Two hours of vomiting will do that to you.
Meredith: (voiceover) We don't say 'when' because there's always the possibility for more.
Derek: Addison and I are over Adele.
Addison: It's not like we're divorced.
Derek: Practically divorced.
Adele: You've had counseling?
Derek: We had adultery, that was enough.
Cristina: Love has its limits.
Cristina (about Judy Dolls): I dissected them, cut off their arms, shaved their heads.
Alex: Sounds like there is a second twisted story behind this...
Cristina: They are sexist, distorted, devil toys creating unrealistic image expectations in the porn driven minds of men.
Bailey: Swallow a bitter pill this morning, Yang? They're dolls!
Richard (to George): Call three times a day.
Adele: Do not call three times a day.
Richard: And if my wife doesn't put you through--
Adele: I won't put you through.
Richard: Keep calling until she does.
George: Yes, sir.
Derek: Just when the day was improving.
Addison: You told Meredith what happened.
Derek: I did. What'd you tell her?
Addison: Sometimes people do desperate things to attract attention.
Derek: Wow, that's your side of this? That I didn't pay you enough attention? Is that what you were thinking when you got naked with my best friend?
Addison: Well, at that point, I wasn't thinking at all, Derek, I was just scratching an itch. We got successful, you and me. We got busy and we got lazy. We didn't even bother to fight any more, Derek, and Mark was there and I missed you and now I'm sorry. I'm more sorry than you could possibly imagine, but at least I'm talking to you about it.
Derek: I'm a sink with an open drain, Addy.
Meredith (closing voiceover): There's something to be said about a glass half full. About knowing when to say when. I think it's a floating line. A barometer of need and desire. It's entirely up to the individual. And depends on what's being poured. Sometimes all we want is a taste. Other times there's no such thing as enough, the glass is bottomless. And all we want, is more.