Ratings: 10.6 million viewers

This episode was nominated for the 2005-2006 Emmy Award for Outstanding Writing For A Drama Series.

Meredith: (voiceover) But as human beings sometimes it's better to stay in the dark. Because... in the dark, there may be fear, but there's also hope.

Meredith: So basically whoever you move doesn't stand a chance. So how do you choose? How do you decide who gets to live?

Izzie: (referring to Addison) For what it's worth, I take issue with her salmon colored scrubs. I mean what self respecting surgeon wears salmon colored scrubs?
Meredith: This is what I'm saying.

Meredith: I hope you find your mojo Alex. I find you disturbing without it.
Alex: Me too.

(Derek gives Meredith a nod)
George: Was that a nod?
Meredith: Yes.
George: Do we know what it meant?
Meredith: No.

Meredith: You operated on a heart earlier, George. You'd think you could draw a little blood.
George: I rocked that heart.
Meredith: Yeah, you did!
George: I think I'm strung out on the scalpel.

Meredith: (voiceover) Whoever said "What you don't know can't hurt you" was a complete and total moron. Because...for most people I know, not knowing is the worst feeling in the world.

Cristina: You're my boyfriend! I mean, I know I don't have much experience with this kind of thing but, aren't boyfriends supposed to help in situations like this?
Burke: Cristina, when we're on duty I can't be your boyfriend.
Cristina: Ok, so when we're on duty, I can have sex with someone else?
Burke: Dr. Yang, I'm walking away now.

Episode Title: Into You Like a Train

"Into You Like a Train" is a song sung by both Jawbreaker and The Psychedelic Furs.

Alex's "new found fear of scalpals" and George being "strung out on surgery" are both references to "Bring The Pain".