Meredith (opening voiceover): When you were a kid, it was Halloween candy. You hid it from your parents and you ate it until you got sick. In college, it was the heavy combo of youth, tequila and well, you know. As a surgeon, you take as much of the good as you can get because it doesn't come around nearly as often as it should. 'Cause good things aren't always what they seem. Too much of anything, even love, is not always a good thing.
Meredith: There's a boy in my bed.
Cristina: What's his name?
Meredith: Um... Steve.
Cristina: Where'd you find him?
Cristina: Hmm. Guess where I am?
Cristina: Burke's apartment. He went to the hospital. He left me alone here.
Meredith: You're going through his stuff, aren't you?
Cristina: There's no stuff to go through. It's a freak show. I mean, you can do surgery in here. Oh, he arranged his books using the Dewey Decimal system! Mer, I'm scared.
Meredith: Get out. Get out of the house now.
Cristina: What the hell is this?
Burke: It's a key.
Burke: Why is it a key? Are we feeling existential this morning?
Cristina: Well, if the key turns in a lock, and no one asked for the key or even wanted the key, does it make a sound?
(As Meredith's one night stand runs out of the house)
Izzie: I shall name him...running guy.
Derek: So, when did you last ejaculate?
Patient: I'm not sure. Meredith?
Bailey: Well we've tried everything, it must be neural.
Cristina: She already called for a consult.
Derek: Hello everybody, what's up?
Meredith: Burke keyed you?
Cristina: I got freaking keyed before coffee.
Cristina: Congratulations, you're flaccid.
Patient: Never thought I'd be glad to hear that.
Alex: So, you're still not taking to me?
Olivia: You gave me syphilis. And I am talking to you; I just don't have anything to say. (pause) How's George?
Alex: O'Malley's a fetus. It's all whiny and frail and light. So you didn't tell him you were doing me, big deal. Minimal disclosure. It's my policy.
Derek: When did you two start seeing each other?
Meredith (quickly): We're not. Seeing each other.
Steve: We met at Joe's last night.
Derek: Joe's bar? (he chuckles) Mmmhmm. I met a girl there once myself. (he looks at Meredith) A very long time ago.
Meredith (closing voiceover): How do you know when how much is too much? Too much too soon. Too much information. Too much fun. Too much love. Too much to ask... And when is it all just too much to bear?
Episode Title: Much Too Much
"Much Too Much" is the name of a song by The Who.
Sleepless in Seattle: George says to Izzie "Well, another sleepless night in Seattle."
This is an allusion to the 1993 film by Nora Ephron Sleepless in Seattle starring Meg Ryan and Tom Hanks.
The Silence of the Lambs: George says "I think you'll find yourself in a hole in some guy's basement being ordered to put the lotion on the skin or else you'll get the hose again."
This is an allusion to the 1991 film The Silence of the Lambs.