Meredith: (opening voiceover) In 6500 BC, some guy looked at his friend and said, let's drill a hole in your head... that will make you feel better. And thus surgery was born. It takes a certain brand of crazy to think of drilling into someone's skull, but surgeons have always been a confident bunch. We don't always know what we're doing, but we act like we do. We walk into a country, plant a flag and start ordering people around. It's invigorating and terrifying.

Izzie: (to Alex) Give me back my surgery or I'll shoot your ass off!

Izzie: People are terrible to the people they love sometimes. They're mean. You were both having a hard time and you took it out on each other. It doesn't make you the worst wife in the world. It just makes you a person who made a mistake.

(at the dermatology office)
Cristina: We are not happy, glowy people.
Izzie and Meredith: Yeah.
Cristina: We need to get out of here.
Izzie and Meredith: Yeah.

Erica: (to Meredith) Lie to me again and the only heart you'll ever see is yours as I'm cutting it out of your chest with a steak knife.

Meredith: (closing voiceover) We like to think we're fearless, eager to explore unknown lands and soak up new experiences, but the fact is, we're always terrified. Maybe the terror is part of the attraction. Some people go to horror movies. We cut things open. Dive into dark water. And at the end of the day, isn't that what you'd rather to hear about? If you've got one drink and one friend and 45 minutes. Slow rides make for boring stories. A little calamity. Now that's worth talking about.

Episode Title: Brave New World

"Brave New World" is the title of a song recorded by several artists including Iron Maiden, Styx, Motorhead, and Steve Miller Band.