Meredith: (opening voiceover) My mother called it the greatest and most terrifying moment in her life. Standing at the head of the surgical table, knowing that the patient's life depends on you and you alone. It's what we all dream about. Because the first person that gets to fly solo in the O.R. ... kind of a bad ass.

Cristina: You won your solo surgery?
Bailey: I was going to pretend you didn't feel the need to ask me that question. Yang, of course I won, I was good.

Lexie: Come on, am I really so bad?
Mark: No. I am.
(they kiss)

George: I don't know if I'm more jealous of Alex or worried about Izzie. I think there's something wrong with her, Mer.
Meredith: There's something wrong with all of us, George.

Lexie: (to Mark) Hi. I get it. I'm the one who organised a crazy cabal of secret-cutter interns. The thing is, I've been advised to seek out sex as a way out of my sad predicament but I think I would rather just learn today.

Meredith: (closing voiceover) We enter the world alone and we leave it alone and everything that happens in between we owe it to ourselves to find a little company. We need help, we need support, othersise we are in it by ourselves. Strangers, cut off from each other, and we forget, just how connected we all are. So instead, we choose love, we choose life, and, for a moment, we feel just a little bit less alone.

The way Alex's name is written on the surgery board changes from "Karev, A." to "Karev" during the scene in which Cristina chooses the person to perform the solo surgery.

Episode Title: All By Myself

"All By Myself" is the title of a song by Celine Dion.

Meredith: That's one of us down there. Show some respect.

Meredith said the same thing about George when he was performing an appendectomy in "A Hard Day's Night."