This episode was part of the crossover event with Private Practice.

Kevin McKidd (Owen Hunt) is now listed as a main cast member and has been added to the opening credits.

Derek: This is stupid. She's gonna hate this.
Mark: What? Flowers? Girls love this crap.
Derek: It's cliche. I'm a cliche!
Mark: Cliches became cliches for a reason. Because they worked. It's great, isn't it? When you feel so strongly for someone and it's not just about the sex, it is... it's true.
Derek: You should not talk like that.

Lexie: Hey, do you mind if I sit here?
Callie: No. No. (does a shot) I'm just overthinking.
Lexie: You think that he'll tell 'em?
Callie: If he's not an idiot.

Arizona: Dixon's right, you know. You do belong in peds surgery.
Bailey: My own baby almost died last year. Doctors in this hospital, my friends, they all worked to save his life, and I stood outside the room feelin' so useless, so pointless and helpless like I was losing everything in the world. And when he didn't die, see, I knew that I didn't wanna be anywhere near that feeling again. So, I think that makes me pretty unsuitable for pediatric surgery.
Arizona: I'd say that, that makes you uniquely qualified.

Episode Title: Beat Your Heart Out

"Beat Your Heart Out" is the title of a song by The Distillers.