Lexie: I'm so sorry.
Mark: It was worth it.
Lexie: No, it wasn't. Maybe a little. Thank you.

Bailey: I don't see anyone burnin' the place down.
Izzie: That's how they do it. They do everything right, and then as soon as you look away and they screw it all up.
Bailey: Hey, I'm sorry, earlier I was busy. I was busy with myself, so I'm sorry.
Izzie: Don't be. I called you an ass. And you were right, I think that I just needed to vent. I'm sick of this place.
Bailey: Hell, I just watched Derek Shepherd beat up a man because he's so sick of it. That's just the way it works. The patients we lose, the mistakes we make, that's how we learn. That's always how it's been done. If you figure out a better way, you Izzie Stevens will be a better doctor than the rest of us.

Derek: Put down the scalpel, Addison!
Addison: You put down the scalpel.
Derek: Addison, put the scalpel down.
Addison: You put the scalpel down! You have to let her go.
Derek: Take your hand off the scalpel, Addison! You take your ... Take it off!
Addison: Meredith, go get the chief.
Derek: Do not go anywhere.
Addison: Karev, go! Derek, don't do this.
Derek: Do not touch my patient, Addison!

Derek's glasses change positions on his face during the scene in which Addison tries to convince Derek to let her deliver Jen's baby before he operates.

Episode Title: An Honest Mistake

"An Honest Mistake" is the title of a song by The Bravery.

This episode concluded a cross-over with spin-off series Private Practice, the first episode being "Before and After."