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Grey's Anatomy Episode Guide

1 :01x01 - A Hard Day's Night

First aired: Mar/27/2005
Writer: Shonda Rhimes
Director: Peter Horton
Guest star: Randall Arney (Mr. Bryce), Martin Ighani (Rectal Exam Patient), Skyler Shaye (Katie Bryce), Robbie Troy (Ms. Bryce), David Vegh (Tony Savitch), Laura Carson (Gloria Savitch), Moe Irvin (Nurse Tyler Christian), Sendhil Ramamurthy (Intern #2), Lynne Marie Stewart (Nurse), Sean Palmer (Intern #3), Richard Gilbert-Hill (Small Town Doc), Grinnell Morris (Intern #4), Kathleen M. Darcy (Anesthesiologist), Brad Pennington (Radiologist), Noelle McCutchen (Nurse #2), Josh Bywater (Intern #1), Gregory Erff (Mr. Jones), Billy Wood (Senior Resident)

On the morning of her first day as a surgical intern at Seattle Grace Hospital, Meredith Grey is running late as she recovers from a one-night stand and prepares for her first day. Meredith quickly befriends George O'Malley, who's quirky, yet lovable, Cristina Yang, a highly competitive woman, and Izzie Stevens, a model turned surgical intern. Each of the new interns get assigned to Dr. Miranda Bailey, who past interns have dubbed "the Nazi".

Meredith's first patient, a young beauty pageant contestant, recently began having severe, life-threatening seizures and Meredith uncovers that she'll need brain surgery to save her life. However, things take a turn when the neurosurgeon, Dr. Derek Shepard, happens to be Meredith's one-night stand. He wants their brief relationship to progress into something more, but Meredith is firm on her stance - their relationship should remain strictly professional.



2 :01x02 - The First Cut Is the Deepest

First aired: Apr/03/2005
Writer: Shonda Rhimes
Director: Peter Horton
Guest star: Kate Burton (Ellis Grey), Alice Lo (Qing Lu), Robin Pearson Rose (Patricia), Kristy Munden (Trauma Nurse), Scott Michael Morgan (Patient #2), Sonia Jackson (Patient #1), Kerri Higuchi (Pediatrics Intern), Walter Wong (Tech), Scarlett Lam (Ahn), Kerry Carney (Intern #1), Dennis Gubbins (Paul), Stacey Hinnen (Mr. Johnson), Elise Robertson (Ms. Johnson), Alex Thayer (Allison), Jeff Marlow (Drunk Man), Kylie Dragna (Ellen Parkins), Shannon Burwell (Crying Patient), Gary Kraus (Louis Cardon), Stephen Blackehart (Vic), Cindy Drummond (Louis' Wife), Helen McCardle (ER Doc (as Helene McCardle)), Chip Keyes (Big Man), Andre Panossian (Code Team Leader), Patricia Harris-Smith (Patient's Wife), Debra Holt (Big Man's Wife), Nate Reese (Father of Patient #1), Joan McCrea (Louis' Wife's Mother), Linda Nile (Louis' Wife's Sister)

The surgical staff tries to stay positive when a young woman, despite brain surgery, is clinging to life after a brutal attempted rape. Meanwhile, Meredith risks her spot in the intern program when she crosses the line in order to save a newborn suffering from a undiagnosed heart condition. The other interns learn that in order to be a good surgeon and doctor, much more than medial knowledge is needed.



3 :01x03 - Winning a Battle, Losing the War

First aired: Apr/10/2005
Writer: Shonda Rhimes
Director: Tony Goldwyn
Guest star: Callum Blue (Viper), Keith David (Lloyd Mackie), Kristy Munden (Trauma Nurse (Kristy L. Munden)), Kathleen M. Darcy (Anesthesiologist), Dinah Lee (Grungy Chick), Kelsy Kemper (Shelley's Daughter), Rudolph McCollum (Vipor's Male Friend), Claire Lautier (Shelly), Steven W. Bailey (Anesthesiologist Jeremy), Zina Zaflow (Nurse)

On the day of a bike race, injured individuals flood into the hospital, including a pedestrian who is left brain dead. Seeing that he has no chance of ever waking up, Cristina and Izzie wish to use his organs for organ donation, but find that the process is an emotional one. George gets assigned to Mack, a good friend of Chief Webber, and constantly flirts with George. Meanwhile, Meredith continues to try to distance herself from Derek and is forced to deal with Alex's big ego, but through the day, Meredith begins to realize the key to winning the battle.



4 :01x04 - No Man's Land

First aired: Apr/17/2005
Writer: James D. Parriott
Director: Adam Davidson
Guest star: Anna Maria Horsford (Nurse Liz Fallon), F. J. Rio (Jorge Cruz), Valerie Cruz (Zona Cruz), Kate Burton (Ellis Grey), Taylor Nichols (Rick Humphrey), Tom Choi (Flouroscope Tech), Chris Hendrie (Dr. Harry Victor), Helen McCardle (ER Doc), Jack Merrill (Radiology Tech #2), John O'Brien (Radiology Tech #1), Moe Irvin (Nurse Tyler Christian), Linda Klein (Nurse Linda)

While George begins to feel that he's loosing his masculinity due to Izzie and Meredith treating him like a sister, Izzie's newest patient may loose his masculinity to prostate cancer. Cristina assigns herself to a sick woman, who she believes will need surgery, but ends up learning more from the woman then standing in on a surgery would ever give her. Meredith faces the reality of her mother's Alzheimer's when Derek treats a patient with nails in his brain. Meanwhile, Alex tapes up pictures of Izzie's racy spread all over the locker room.



5 :01x05 - Shake Your Groove Thing

First aired: Apr/24/2005
Writer: Ann Lewis Hamilton
Director: John David Coles
Guest star: Brent Sexton (Jerry Frost), Kathryn Joosten (Mrs. Drake), Barry Shabaka Henley (Mr. Patterson), Kate Burton (Ellis Grey), Jonathan Scarfe (Hank), Moe Irvin (Nurse Tyler Christian), Kate Forster (Jane Richie), Vladimir Rajcic (Resident Doctor), Jeff Doucette (Warren Sterman), Steven W. Bailey (Anesthesiologist Jeremy), Jane Morris (Ms. Goff), Andre Panossian (Perfusionist)

Meredith realizes the responsibility of adulthood when her mother has to sign all of her assets over to her. Izzie decides to throw a party for her boyfriend, Hank, and the scale of the party, which Meredith is unaware of, increases throughout the day. After popping a glove during a heart surgery, Meredith fears that she damaged the patient's heart and has to face a meeting with the chief and lawyers who will determine her future as a doctor. Meanwhile, sparks start to fly between Cristina and Burke, and Meredith and Derek's relationship is exposed when Bailey catches them together at the party.



6 :01x06 - If Tomorrow Never Comes

First aired: May/01/2005
Writer: Krista Vernoff
Director: Scott Brazil
Guest star: Bruce Weitz (Mr. Levangie), Jane Galloway Heitz (Annie's Mother), Alex Alexander (Annie Connors (as Alex S. Alexander)), Lara Phillips (Mary Levangie), Linda Klein (Nurse Linda), Brad Pennington (Radiologist), Moe Irvin (Nurse Tyler Christian), Steven W. Bailey (Anesthesiologist Jeremy), Sean Palmer (Intern), Patricia Bethune (Older Nurse), Yvonne Farrow (Heart Patient's Wife), John O'Brien (CT Tech), Yolanda Snowball (Physical Therapist), Walter Wong (Echo Tech), Noelle McCutchen (Cardiac Nurse), Sharmila Devar (Female Intern)

The interns are speechless when a woman comes in with a large, record-breaking tumor, but unfortunately for the woman, her outlook isn't good. Derek and Meredith's jobs are at risk now that Bailey knows about their relationship, and Dr. Bailey makes it clear that Derek better not give Meredith special treatment. Meanwhile, Izzie urges George to ask Meredith out, and Cristina and Burke's relationship continues to progress.



7 :01x07 - The Self Destruct Button

First aired: May/08/2005
Writer: Kip Koenig
Director: Darnell Martin
Guest star: Russell Hornsby (Digby Owens), Ever Carradine (Athena), Kim Morgan Greene (Mrs. Rice), Amanda MacDonald (Claire Rice), Shenita Moore (Surgical Nurse), Sarah Utterback (Nurse Olivia Harper), Rebecca Rogers (Jamie Hayes), Vanessa Rogers (Jamie Hayes), Joseph Kell (Mr. Rice), Regan Forman (Gwen Hayes), Bill Birch (J.P.), Larry Cahn (Dr. Taylor), Doug Sinclair (Brett Hayes), Steve Monroe (Orderly)

Derek and Meredith try to spend a night together at Meredith's, but their appearance the next morning does more harm than they expected and leads Bailey to tell Meredith to end it. Alex treats a self-mutilation patient, while Izzie's patient literally won't let go of his girlfriend. Meanwhile, George is suspicious that an anesthesiologist is drinking on the job and Cristina fills ill with flu-like symptoms.



8 :01x08 - Save Me

First aired: May/15/2005
Writer: Mimi Schmir
Director: Sarah Pia Anderson
Guest star: Joan McMurtrey (Zoey Glass), Kevin Rahm (Mr. Duff - Psychic Guy), Sarah Hagan (Devo Friedman), Josh Stamberg (Tommy Walker), Steven W. Bailey (Anesthesiologist Jeremy), Anjul Nigam (Psych Intern), Sarah Utterback (Nurse Olivia Harper), Ping Wu (Seymour Glass), Charles Walker (Dr. Chesney), Chad Einbinder (Sam Friedman), Lisa Kaminir (Doris Friedman), Kathleen Bailey (Reproductive Counselor), Darlene Kegan (Ruby Walker)

The interns treat a patient who, after a series of seizures, thinks he's gained psychic abilities. Meredith becomes dissatisfied with her relationship with Derek when she realizes that she knows nothing about his personal life. Alex treats a patient whose religion interferes with her recovery; Izzie debates whether or not to reconnect with her mother; and Cristina's patient disagrees with her medical advice.



9 :01x09 - Who's Zoomin' Who?

First aired: May/22/2005
Writer: Gabrielle Stanton, Harry Werksman
Director: Wendey Stanzler
Guest star: Wendy Davis (Holly Adams), Lauren Bowles (Alice Franklin), Kate Walsh (Addison Montgomery-Shepherd), Wayne Wilderson (Bill Adams), Patricia McCormack (Rebecca Franklin (as Patty McCormack)), Catherine Dao (Dr. Knox), Sarah Utterback (Nurse Olivia Harper), Joyce Guy (Ms. Henry), Jack Merrill (Lab Tech), Robin Pearson Rose (Patricia), Jack Shearer (Jordan Franklin)

When an STD breaks out, affecting several members of the staff, Webber calls a staff meeting. Later, the chief confides in Derek about his own medical concerns. Izzie and Cristina become stressed when a patient's wife and daughter can't decide on his care. Burke treats an old college friend, Bill, but his diagnosis creates questions about his wife. As Meredith and Derek continue to get closer, their relationship crashes down around them when a person from Derek's past shows up in his life.



Straight to the Heart

First aired: Jan/08/2006
Guest star: Steven W. Bailey (Narrator)

See how it all began ...

Straight to the Heart re-examines the lives of the five interns and their past relationships, both personal and professional.



Under Pressure

First aired: Apr/23/2006
Guest star: Steven W. Bailey (Narrator)

A one-hour special recaping the lives of the interns at Seattle Grace Hospital. Starting with their first day, the intern's lives, both personal and professional, are recapped, along with the struggles of their first year of being surgical interns.



10 :02x01 - Raindrops Keep Falling On My Head

First aired: Sep/25/2005
Writer: Stacy McKee
Director: Peter Horton
Guest star: Kate Walsh (Addison Montgomery-Shepherd), Steven W. Bailey (Joe), Wendy Gazelle (Julie Phillips), Jeremy Rabb (Resident), Linda Klein (Nurse Linda), Noelle McCutchen (Nurse Vivian), Robin Pearson Rose (Patricia), Tracey Evans (Donor Woman)

While off from work, Meredith and Cristina discuss their mutual man problems and are interrupted when Joe, the bartender, collapses. While Webber recovers from his surgery, he appoints one of the surgeons as interim chief, but has George report to him all the happenings at the hospital. While Meredith learns more about Derek and Addison's past relationship, Cristina tries to decide what to do in her relationship with Burke.



11 :02x02 - Enough Is Enough (No More Tears)

First aired: Oct/02/2005
Writer: James D. Parriott
Director: Peter Horton
Guest star: Kate Walsh (Addison Montgomery-Shepherd), Sarah Utterback (Nurse Olivia Harper), Loretta Devine (Adele Webber), Scott Michael Campbell (Mr. Hubble), Lukas Behnken (Scott Seibert), Romy Rosemont (Lea Seibert), Linda Klein (Nurse Linda), Jeremy Rabb (ER Resident), Seth Adams (Radiologist), Jim Gleason (Dr. Domner), Yvette Cruise (Scrub Nurse), Johanna McKay (Grieving Widow), Robin Pearson Rose (Patricia), John Cappon (Paramedic #1), David Haley (Paramedic #2), Peter Birkenhead (Dr. Orsen)

A family arrives at Seattle Grace after a car accident. While treating the members of the family, Alex discovers that their problems are deeper than their injuries. Meanwhile, Mrs. Webber admits her marital worries to Richard as he recovers.



12 :02x03 - Make Me Lose Control

First aired: Oct/09/2005
Writer: Krista Vernoff
Director: Adam Davidson
Guest star: Kate Walsh (Addison Montgomery-Shepherd), Kate Burton (Ellis Grey), Angela Goethals (Kelly), Jeremy Rabb (Resident #1), Linda Klein (Nurse Linda), Noelle McCutchen (Nurse Vivian), Stephen Breithaupt (Mr. Geston), John O'Brien (Lab Technician)

Meredith's secrets about the state of her mother, Ellis Grey, are revealed to the staff when Ellis is brought in for surgery. Meanwhile, secrets about Cristina's health are also revealed.



13 :02x04 - Deny, Deny, Deny

First aired: Oct/16/2005
Writer: Zoanne Clack
Director: Wendey Stanzler
Guest star: Kate Walsh (Addison Montgomery-Shepherd), Kate Burton (Ellis Grey), Steven W. Bailey (Joe), Tsai Chin (Helen), Lee Garlington (Farah Linden), Don McManus (Samuel Linden), Katherine La Nasa (Kalpana Vera), Thomas Ian Nicholas (Jeremiah Tate), Kathleen M. Darcy (Anesthesiologist), Moe Irvin (Nurse Tyler Christian), Don Wilson (Radiology Tech), Linda Eve Miller (ER Nurse), Noelle McCutchen (Nurse Vivian)

While trying to recover, Cristina proves to be a difficult patient, and matters are made worse when her mother visits. Ellis Grey, Meredith's mother also proves to be a difficult patient when she has the staff running in circles to please her. Derek and Meredith's relationship remains in limbo when Addison's departure is postponed when she becomes involved with the treatment of a cystic fibrosis patient.



14 :02x05 - Bring The Pain

First aired: Oct/23/2005
Writer: Shonda Rhimes
Director: Mark Tinker
Guest star: Kate Walsh (Addison Montgomery-Shepherd), Steven W. Bailey (Joe), Mimi Kennedy (Verna Bradley), François Chao (Mr. Chue), Brent Briscoe (Henry Lamott), Michelle Krusiec (Anna Chue), Daniel Bess (Pete Willoughby), Kate Burton (Ellis Grey), Jeremy Rabb (ER Resident), Bashir Salahuddin (Bailey's Husband), Sally Ann Brooks (Marie Lamott), Sean Moran (Lou Bradley)

Meredith and Derek have to use more than their medical knowledge when a woman's strictly religious father forbids her from having an operation that would save her life. Meanwhile, George and Alex are forced to perform a surgery in scarce conditions, and Derek is forced to decide between Addison and Meredith.



15 :02x06 - Into You Like A Train

First aired: Oct/30/2005
Writer: Krista Vernoff
Director: Jeff Melman
Guest star: Kate Walsh (Addison Montgomery-Shepherd), Steven W. Bailey (Joe), Cynthia Ettinger (Jana), Juliette Jeffers (Mary), Michelle Arthur (Brooke), Monica Keena (Bonnie), Bruce A. Young (Tom), Kim Whitley (Yvonne (as Kym Whitley)), Linda Klein (Nurse Linda), Chad Fisk (Med Tech #2), Brooke Blanchard (Jill the Paramedic), Michael Barreta (Danny), Derick Alexander (Lab Tech), Rigo Sanchez (Stan the Paramedic), Marty Lodge (Anesthesiologist), Ariel Felix (Intern #1), Ray Ford (Ray the Paramedic), Karen Lew (Dr. Hoffman), Yvette Cruise (Scrub Nurse), Kerry Carney (Intern #2), Patricia Bethune (Nurse Ginger), Moe Irvin (Nurse Tyler Christian), Robin Pearson Rose (Patricia)

Meredith temporarily forgets her worries about Derek's decision when a train crash results in dozens of injuries. Later, Addison sees potential in Izzie, but Izzie is forced to choose between her friendship with Meredith or her career.



16 :02x07 - Something to Talk About

First aired: Nov/06/2005
Writer: Stacy McKee
Director: Adam Davidson
Guest star: Steven W. Bailey (Joe), Francis Guinan (Mr. Verma), Elaine Kagan (Mrs. Griswold), Tyrees Allen (Dr. Saltzman), Patti Yasutake (Mrs. Verma), Michelle Ongkingco (Nicole Verma), Joseph Sikora (Shane), Reni Santoni (Mr. Griswold), Gianin Loffler (Psych Patient #2), Keeshan Giles (Intern #3), Peyton Hinson (Intern #2), Larry Weissman (Psych Patient #1), Maile Flanagan (Tech), Kerry Carney (Intern #1), Cathy Lind Hayes (Debbie), Moe Irvin (Nurse Tyler Christian), Alison Ward (Tina Herman)

The entire staff is in awe when a patient, Shane, comes in with a hysterical pregnancy while Cristina, Izzie and Meredith aggressively work on his unique case. Meanwhile, Alex is encouraged to show his feelings for Izzie after treating a young, sheltered young patient.



17 :02x08 - Let It Be

First aired: Nov/13/2005
Writer: Mimi Schmir
Director: Lesli Linka Glatter
Guest star: Arija Bareikis (Savannah), Janet Rotblatt (Esme), Joseph Lyle Taylor (Weiss), Geoffrey Rivas (Stu), Brittany Ishibashi (Talia), Shelley Berman (Jed), Linda Klein (Nurse Linda), Kate Blumberg (Daisy), Brian Reid (Waiter), Ray Ford (Ray the Paramedic), Kathleen M. Darcy (Anesthesiologist), Kai Lennox (Speed)

Friends of Derek and Addison come to Seattle Grace for preemptive surgery to avoid breast and ovarian cancer. But the arrival of their friends tests Derek and Addison's professional relationship. Meanwhile, George treats a patient who fell five stories and is dissatisfied with his outcome and Cristina and Burke attempt a "normal" date.



18 :02x09 - Thanks for the Memories

First aired: Nov/20/2005
Writer: Shonda Rhimes
Director: Michael Dinner
Guest star: Brian Kerwin (Holden McKee), Greg Pitts (Jerry O'Malley), Tim Griffin (Ronny O'Malley), Sarah Utterback (Nurse Olivia Harper), Steven W. Bailey (Joe), Michael Matthys (Dr. Kent), Gregor Manns (Levi Johnson), Mike Faiola (Guy), Andrew James Allen (Coby McKee), Dee Nelson (Cheryl Leonard), Peter Howard (Hal Leonard), Jack Yang (Walter), George Dzundza (Harold O'Malley)

Thanksgiving proves to be a difficult holiday for both the interns and residents. Izzie plans a big dinner, but it doesn't look like all the invited guests will show up. Meanwhile, George participates in the O'Malley turkey hunting tradition, which abruptly ends after a shooting accident and Meredith treats a comatose patient whose condition might be better than it appears.



19 :02x10 - Much Too Much

First aired: Nov/27/2005
Writer: Harry Werksman, Gabrielle Stanton
Director: Wendy Stanzler
Guest star: Sunkrish Bala (Steve Murphy), Curtis Armstrong (Mr. Martin), Margaret Welsh (Dorie Russell), Sarah Utterback (Nurse Olivia Harper), Robin Pearson Rose (Patricia), Pat Healy (Tom Russell), Jon Hershfield (Doyle)

Meredith is horrified when her one-night stand needs treatment after suffering from priapism. Meanwhile, Alex begins to frustrate Izzie and a pregnant woman carrying quintuplets stresses over her high-risk pregnancy.



20 :02x11 - Owner of a Lonely Heart

First aired: Dec/04/2005
Writer: Mark Wilding
Director: Dan Minahan
Guest star: Rosanna Arquette (Constance Ferguson), Timothy Bottoms (Mr. Murphy), Curtis Armstrong (Mr. Martin), Pat Healy (Tom Russell), Margaret Welsh (Dorie Russell), Sarah Utterback (Nurse Olivia Harper), Patricia Bethune (Nurse Ginger), Monica Garcia (Peds Nurse), Elaine Kao (NICU Nurse), Brooke Blanchard (Jill the Paramedic), Amie Donegan (NICU Nurse #2)

Cristina finds little sympathy for an inmate who purposely endangers her health to get out of serving her term in solitary confinement. Meanwhile, the interns are put in charge of watching the newborn quintuplets, each with varying health concerns; Izzie's frustrations with Alex's shortcomings hit their end; and Derek teaches Izzie an important, yet painful lesson.



21 :02x12 - Grandma Got Run Over By a Reindeer

First aired: Dec/11/2005
Writer: Krista Vernoff
Director: Peter Horton
Guest star: Rik Deskin (Pedestrian #1), Helen Slater (Mrs. Shelton), Richard Jenik (Jimmy Shelton), Steven W. Bailey (Joe), Robin Pearson Rose (Patricia), Kathe Mazur (Mrs. Hasting (as Kathe Mazur)), Jenny O'Hara (Mrs. Shelton's Mother), Michael Hyatt (Mariann), Andrew Bilgore (Tim Hasting), C. J. Sanders (Justin), Sarah McDermott (Leah), Troy Curvey, Jr. (Priest), Alan Fudge (Ernie), Kathleen M. Darcy (Anesthesiologist), Alex Stamm (Josh), Linda Klein (Nurse Linda), Savannah McDermott (Jesse), John Cappon (John the Paramedic), Sean McDermott (Jake)

Burke and Cristina's differences are shown when a young boy needs a transplant but he refuses to get it. Meanwhile, the interns help Alex prepare for his exams when it's revealed that he failed them. Meredith has to re-instill the Christmas spirit in Izzie and Derek refuses to feel festive.



22 :02x13 - Begin the Begin

First aired: Jan/15/2006
Writer: Kip Koenig
Director: Jessica Yu
Guest star: Jeffrey Dean Morgan (Denny Duquette), Becca Gardner (Bex), Kate Burton (Ellis Grey), Stephen Spinella (Author), Lauren Tom (Wife), John Prosky (Bex's Father), Shannon Cochran (Bex's Mother), Joyce Guy (Administrator), Rob Narita (Anesthesiologist), Linda Klein (Nurse Linda)

As the new year unfolds, Izzie vows to let Alex's affair go, and it comes easier when she hits it off with Denny Duquette, a heart transplant patient. George treats Bex, a teen hermaphrodite, with a tumor and Alex treats a man who ate his novel after not being pleased with the results. Meanwhile, Derek talks with Meredith's mom, Addison expresses her disgust with Derek's living arrangements, and the residents, especially Cristina, have a hard time dealing with the new work limit.



23 :02x14 - Tell Me Sweet Little Lies

First aired: Jan/22/2006
Writer: Joan Rater, Tony Phelan
Director: Adam Davidson
Guest star: Carole Cook (Mrs. Sophie Larson), Donovan Leitch (Rick Freeark), Nancy Linari (Sophie's Daughter), Robin Pearson Rose (Patricia), Cathy Lind Hayes (Nurse Debbie), Jill Holden (Naomi Cline), Christopher Boyer (Tom Cline), John O'Brien (Jeffrey), Ricardo Molina (ID Resident Amir), Rigo Sanchez (Paramedic), Natalie N. Okamoto (Yumi), Kate Anthony (GI Nurse), Yutaka Takeuchi (Kamaji), Tyshawn Bryant (Friend #1)

Cristina and Meredith hide the truth about their relationships from each other. George is assigned to discharge an elderly patient who refuses to leave; and Alex learns the fate of his career when the results from his medical exams come in.



24 :02x15 - Break on Through

First aired: Jan/29/2006
Writer: Zoanne Clack
Director: David Paymer
Guest star: Leisha Hailey (Claire Solomon), Kenneth Mitchell (Wade Solomon), Sarah Utterback (Nurse Olivia Harper), Betty Garrett (Eleanor), Rae Allen (Ruth), Monica Calhoun (Shyan's Mother), June Lockhart (Agnes), Kali Rocha (Sydney Heron), Steven W. Bailey (Joe), Regine Nehy (Shyan), Robin Pearson Rose (Patricia), Kate Burton (Ellis Grey), Cathy Lind Hayes (Nurse Debbie), Jeremy Rabb (ER Resident), Zibby Allen (Temp Nurse), Kate Anthony (GI Nurse), Donna Hardy (Grace Bickham), Moe Irvin (Nurse Tyler Christian), Amy Cale Peterson (Nurse Home Staffer), Pamela Roylance (Alice Bickham), Teddi Siddall (Anne)

When the nurses at Seattle Grace go on strike, the doctors are forced to work without them. While most of the doctors cross the picket line, George refuses to cross due to his union roots. With Bailey on maternity leave, the interns meet their temporary resident, Dr. Sydney Heron, who is the exact opposite of Dr. Bailey, which Cristina has a hard time adjusting to. Meanwhile, secrets from Izzie's past are revealed as she treats a young, pregnant teen; and Meredith makes a mistake in treating an elderly patient.



25 :02x16 - It's the End of the World (1)

First aired: Feb/05/2006
Writer: Shonda Rhimes
Director: Peter Horton
Guest star: Christina Ricci (Hannah Davies), Kyle Chandler (Dylan Young), Sarah Utterback (Nurse Olivia Harper), Larry Clarke (Paul), Jillian Armenante (Mrs. Carlson), Cress Williams (Tucker), Marty Lodge (Dr. Milton), Moe Irvin (Nurse Tyler Christian), Cathy Lind Hayes (Nurse Debbie), Kathleen M. Darcy (Anesthesiologist), John Bishop (James Carlson), O. Austen Rey (Bomb Squad #1), Jamal Thomas (Larry the Paramedic)

All morning, Meredith felt like she was in for a bad day. Her fears are realized when a medical case threatens the lives of everyone at Seattle Grace, causing officials to put the hospital on a "code black".



26 :02x17 - (As We Know It) (2)

First aired: Feb/12/2006
Writer: Shonda Rhimes
Director: Peter Horton
Guest star: Christina Ricci (Hannah Davies), Kyle Chandler (Dylan Young), Loretta Devine (Adele Webber), Jillian Armenante (Mrs. Carlson), Cress Williams (Tucker), Cathy Lind Hayes (Nurse Debbie), Kathleen M. Darcy (Anesthesiologist), John Bishop (James Carlson), Scott Lusby (Med Tech)

Despite the staff doing all they can, the potentially disastrous situation continues to escalate. Meredith begins to panic about her situation, as does Derek when he's told about her circumstances. Meanwhile, while the hospital is in chaos, Bailey and Webber have to deal with their own health issues.



27 :02x18 - Yesterday

First aired: Feb/19/2006
Writer: Krista Vernoff, Mimi Schmir
Director: Rob Corn
Guest star: Kate Burton (Ellis Grey), Eric Dane (Dr. Mark Sloan), Jeff Perry (Thatcher Grey), Steven W. Bailey (Joe), Julio Oscar Mechoso (Chucky Eaton), Arlene Tur (Pamela), Jesse Plemons (Jake Burton), Carlos Cervantes (Mr. Calva), Deborah Geffner (Mrs. Burton), David Grant Wright (Mr. Burton), Brooke Blanchard (Jill the Paramedic), Ariel Felix (CT Tech), Chad Fisk (The Anesthesiologist)

When a person from Derek and Addison's past arrives at Seattle Grace, their now stable relationship is shaken up. Meanwhile, after visiting with her mother, Burke is told Cristina's secret; and after a visit with her mother, Meredith digs to find the family's secrets.



28 :02x19 - What Have I Done To Deserve This?

First aired: Feb/26/2006
Writer: Stacy McKee
Director: Wendey Stanzler
Guest star: Jeffrey Dean Morgan (Denny Duquette), Sarah Utterback (Nurse Olivia Harper), Cress Williams (Tucker), Sara Ramirez (Dr. Callie Torres), Mark Harelik (Keith Polus), Ann Cusack (Amy), Jonathan Slavin (Rick), Matt Roth (Michael), Noah Gray-Cabey (Shawn Beglighter), Cathy Lind Hayes (Nurse Debbie), Jeremy Rabb (ER Resident), Ray Ford (Ray the Paramedic)

Meredith and George fight over who gets to treat a patient. Bailey, despite being on maternity leave, treats Addison for a specific feminine problem. Izzie starts spending time with Denny, and Alex becomes jealous. Meanwhile, Burke treats a man who had a heart attack, and the man's fiancée leaves him when she learns about the risky surgery he's decided to have.



29 :02x20 - Band Aid Covers the Bullet Hole

First aired: Mar/12/2006
Writer: Harry Werksman, Gabrielle Stanton
Director: Julie Ann Robinson
Guest star: Jeffrey Dean Morgan (Denny Duquette), Teddy Dunn (Heath), Stephen Lee (Mr. Gibson), Sara Ramirez (Dr. Callie Torres), Tim Edward Rhoze (Kyle Booker), Natalie Cole (Sylvia Booker), Kelley Hazen (Mrs. Mercer), Anne Moore (Penny Gibson), Ray Ford (Ray the Paramedic), Helen McCardle (ER Doctor (as Helene McCardle))

Cristina has a hard day on the job when Bailey has her take care of her baby after she gets involved in a case, despite being on maternity leave. Meredith continues to deal with the fact that she slept with George, who begins to bond with Burke much to Cristina's disgust. Addison and Derek have a deep talk about their relationship and Denny continues to get in the way of Alex being closer to Izzie. Meanwhile, the interns must deal with a hockey player who wants an unnecessary amputation and a woman with a fork stuck in her neck.



30 :02x21 - Superstition

First aired: Mar/19/2006
Writer: James D. Parriott
Director: Tricia Brock
Guest star: Mary Kay Place (Ollie), Michaela Watkins (Nikki), Anjul Nigam (Raj), Jeffrey Dean Morgan (Denny Duquette), Sara Ramirez (Dr. Callie Torres), Omar Metwally (Jesse, the OCD Patient), Annie Morgan (Gretchen), Linda Klein (Nurse Linda), Chad Fisk (Richard's Anesthesiologist), Pamela Zane (AA Member #1), Alex Downs (AA Member #2), Domingo Vara (AA Member #3), Tola Thompson (AA Member #4), Kathleen M. Darcy (Derek's Anesthesiologist), Brooke Blanchard (Jill the Paramedic), Wayne Lopez (Paramedic #2), Keeshan Giles (Intern #2), Kerry Carney (Intern #1), Rob Narita (Burke's Anesthesiologist), Kate Anthony (Nurse Kate), Shenita Moore (ER Nurse)

The doctors' superstitious sides are brought out after several deaths and strange events take place at Seattle Grace. Derek and Addison talk about a more permanent living situation, Izzie worries about Denny's surgery, and Richard gets reacquainted with an old friend.



31 :02x22 - Name of the Game

First aired: Apr/02/2006
Writer: Blythe Robe
Director: Seith Mann
Guest star: Chris O'Donnell (Finn Dandridge), Mare Winningham (Susan Grey), Laurie Metcalf (Beatrice), Jeffrey Dean Morgan (Denny Duquette), Sara Ramirez (Dr. Callie Torres), Jeff Perry (Thatcher Grey), Mandy Siegfried (Molly Thompson), Steven W. Bailey (Joe), Jusak Yang Bernhard (Seminar Teacher), Harrison Knight (Andrew), Emilee Wallace (Amelia Carver), Obie Sims (Neuro Fellow), Soledad St. Hilaire (Lola)

Derek performs brain surgery on Andrew, a young spelling bee champion who suffered a serious head injury. George, who begins to overstay is welcome at Burke's, has trouble not speaking up when one of his patients constantly lies about her health to her daughter. Bailey begins to worry that the interns will no longer see her as "the Nazi" now that she has a child. Meanwhile, Addison treats a patient with pregnancy issues; Alex gets a lesson in manners; and secrets are revealed about Meredith's father.



32 :02x23 - Blues for Sister Someone

First aired: Apr/30/2006
Writer: Elizabeth Klaviter
Director: Jeff Melman
Guest star: Chris O'Donnell (Finn Dandridge), Sara Ramirez (Dr. Callie Torres), Jeffrey Dean Morgan (Denny Duquette), Albert Hall (Eugene Foote), Jayne Brook (Gwen Graber), Jean Louisa Kelly (Rose Ward), Andrew Borba (Mr. Ward), Noelle McCutchen (Nurse), Bryce Robinson (Timothy Ward), Kathleen M. Darcy (Burke's Anesthesiologist)

A strict Catholic mother of seven children comes to the hospital to ask Addison for medical help because her equally religious husband refuses to use condoms. Addison is able to come up with a solution to her problem, but Alex's interference causes problems for both Addison and the mother. Derek rethinks his marriage after treating a divorce attorney for seizures. Izzie hounds George for information about his private life and pressures him to move back into the house. Meanwhile, Meredith agrees to go out with Doc's vet and Burke is faced with considerable pressure when he has to operate on his musical hero.



33 :02x24 - Damage Case

First aired: May/07/2006
Writer: Mimi Schmir
Director: Tony Goldwyn
Guest star: Chris O'Donnell (Finn Dandridge), Sara Ramirez (Dr. Callie Torres), Jeffrey Dean Morgan ( Denny Duquette), Frances Fisher (Betty Johnson), John Cho (Marshall), Gabriel Tigerman (Noah Reynolds), Sarah Lafleur (Melanie Reynolds), Graham Beckel (Jim Johnson (as Graham S. Beckel)), Maile Flanagan (CT Tech #1), Ray Ford (Ray the Paramedic), Wayne Lopez (Paramedic #2), Maria Elena Maglaris (Nurse), P. D. Mani (Anesthesiologist), John O'Brien (CT Tech #2), Sean Lake (X-Ray Tech)

The interns attend to Marshall, an intern from another hospital with short-term memory loss. Marshall was also the cause of a bad accident involving a family, which leads Derek to let his emotions get in the way of his work. Meanwhile, a woman from the past comes to visit one of the female interns, and Burke and Izzie have an idea relating to Denny's condition.



34 :02x25 - 17 Seconds

First aired: May/14/2006
Writer: Mark Wilding
Director: Dan Minahan
Guest star: Chris O'Donnell (Finn Dandridge), Sara Ramirez (Dr. Callie Torres), Jeffrey Dean Morgan (Denny Duquette), Ken Marino (Brad), Jesse Head (Will), Sydney Tamiia Poitier (Deborah), Michael Arden (Neal), Michael Milhoan (Doug Thomas), Brooke Smith ( Dr. Erica Hahn), Steven W. Bailey (Joe), Robin Pearson Rose (Patricia), Kathleen M. Darcy (Derek's Anesthesiologist), Toby Meuli (Chaz), Kate Mines (Burke's Nurse), Carmen Mormino (Monnie), David Paluck (Surgeon #2), Jeremy Rabb (ER Resident), Keith Sellon-Wright (Surgeon #1), Patti Tippo (Cindy Thomas), Jennifer Nyholm (Kendra)

Finn continues to work with Doc and is able to give his owners, Meredith and Derek, and update on his condition. George is assigned to work with Derek, while Meredith is assigned to work with Callie. Denny still is without a heart donor, leaving Izzie and Burke to continue the hunt for a potential donor. Meanwhile, a 12-week pregnant woman dies in the O.R., and her parents' decision to try to keep the baby alive creates a rift between Addison and Derek.



35 :02x26 - Deterioration of the Fight or Flight Response

First aired: May/15/2006
Writer: Joan Rater, Tony Phelan
Director: Rob Corn
Guest star: Chris O'Donnell (Finn Dandridge), Sara Ramirez (Dr. Callie Torres), Jeffrey Dean Morgan (Denny Duquette), Loretta Devine (Adele Webber), Hallee Hirsh (Claire), Tessa Thompson (Camille), Tiffany Hines (Natalie), Brooke Smith (Dr. Erica Hahn), Sarah Utterback (Nurse Olivia Harper), Charles Duckworth (Brian), Ariel Felix (Anesthesiologist), Linda Klein (Nurse Linda), David Paluck (Surgeon #2), Jeremy Rabb (ER Resident), Keith Sellon-Wright (Surgeon #1)

George and Izzie race to find Denny a heart as his heart gets weaker and weaker by the minute. Derek is faced with the pressure of performing surgery on one of his friends, while Cristina is faced with the pressure of running the O.R. after she is left in charge. Meanwhile, the interns are supervised by Erica, a new attending, who tries her hardest to act like Bailey, but has a tough time doing so.



36 :02x27 - Losing My Religion

First aired: May/15/2006
Writer: Shonda Rhimes
Director: Mark Tinker
Guest star: Chris O'Donnell (Finn Dandridge), Sara Ramirez (Dr. Callie Torres), Jeffrey Dean Morgan (Denny Duquette), Loretta Devine (Adele Webber), Hallee Hirsh (Claire), Tessa Thompson (Camille), Tiffany Hines (Natalie), Brooke Smith (Dr. Erica Hahn), Charles Duckworth (Brian), Sarah Utterback (Nurse Olivia Harper), Linda Klein (Nurse Linda), Ariel Felix (Anesthesiologist)

After Richard learns who Derek is operating on, he tries to pump Addison for information. Callie and George have a talk about their relationship and George's true feelings. Meanwhile, Meredith and Derek get together to talk about Doc, and later realize that their feelings for each other may not entirely be gone despite Finn being in Meredith's life and Addison being in Derek's.



Complications of the Heart

First aired: Sep/21/2006
Guest star: Steven W. Bailey (Narrator)

In a clip-show, "Complications of the Heart" recaps the highlights of the previous season from the arrival of Addison to Meredith's cliff-hanging season finale scene. The episode will also feature the music video for The Fray’s single, “How to Save a Life" which features clips from season 2 as well as clips from the season 3 premiere.



Every Moment Counts

First aired: Apr/12/2007
Guest star: Jeffrey Dean Morgan (Denny Duquette (Host))

"Every Moment Counts" recaps the events of the third season. Hosted by recurring guest star Jeffrey Dean Morgan (Denny Duquette), a montage of memorable scenes from the third season are shown as well as the premiere of an exclusive Grey's Anatomy music video set to Brandi Carlile's, "The Story."



37 :03x01 - Time Has Come Today

First aired: Sep/21/2006
Writer: Shonda Rhimes
Director: Dan Minahan
Guest star: Chris O'Donnell (Finn Dandridge), Steven W. Bailey (Joe), Kate Burton (Ellis Grey), Loretta Devine (Adele Webber), Jessica Tuck (Shannon's Mom), Sarah Utterback (Nurse Olivia Harper), Joanie Fox (Sara's Mom), Mis Qesley (Karen's Mom), Pepper Sweeney (Lisa's Dad), Robin Pearson Rose ( Patricia), Jeremy Rabb (ER Doctor), Haley Ramm (Shannon), Kelli King (Sara), Wayne Lopez (Paramedic), Frank Merino (Funeral Home Guy), Damon Standifer (Hazmat Guy), Matt Crabtree (IDC Dude), Elizabeth Goldstein (Giselle), Alexandra Brandl (Karen), Paulina Olszynski (Lisa), Nicolette Collier (Young Meredith), Steve Harris (Omar)

In the fallout of Izzie's decision to quit the program, the interns try to help Izzie come to terms with the death of her fiancé, Denny. Meredith is forced to decide who will be the man in her future after her fling with Derek during the prom. Meanwhile, Dr. Webber is confronted by his wife after spending the night at the hospital; George asks an unlikely person for relationship advice; and Addison must find out which one of a group of teenaged girls is the mother of a baby found in a trashcan.



38 :03x02 - I Am a Tree

First aired: Sep/28/2006
Writer: Krista Vernoff
Director: Jeff Melman
Guest star: Chris O'Donnell (Finn Dandridge), Diahann Carroll (Jane Burke), Richard Roundtree (Donald Burke), Roxanne Hart (Dana Seabury), Steven W. Bailey (Joe), Elizabeth Sampson (Ruth O'Leary), Javier Grajeda (Jeffrey Hernandez), Peter Paige (Benjamin O'Leary), Moe Irvin (Nurse Tyler Christian), Brandon Melgar (Harley), Zibby Allen (Cute Nurse), Brooke Blanchard (Jill the Paramedic)

While Burke continues to recuperate in the hospital, his parents arrive at Seattle Grace to visit and end up meeting Cristina in embarrassing circumstances. The interns, as well as Bailey, lobby for Izzie to be re-admitted to the intern program. Meanwhile, Addison opts to take a day off from the hospital and spends the day at Joe's where she runs into both Izzie and a surprise visitor from her and Derek's past. Elsewhere at the hospital, a patient lives what she believes to be her last day to the fullest.



39 :03x03 - Sometimes a Fantasy

First aired: Oct/05/2006
Writer: Debra Cahn
Director: Adam Arkin
Guest star: Abigail Breslin (Megan Culver), Eric Dane (Dr. Mark Sloan), Chris O'Donnell (Finn Dandridge), Jack Conley (Jasper Hovey), Gabriel Casseus (Taylor Tressel), Stephanie Erb (Megan's Mother), Lanai Chapman (Lianne Tressel), Kevin Will (Len Gantry), Linda Eve Miller (ER Nurse), Daniel Tatar (Hotel Clerk #1), Julie Granata (Hotel Clerk #2)

Finn and Derek continue to try to outdo one another in order to win Meredith's heart. Derek woos Meredith with once in a lifetime surgeries while Finn tries his hand at a romantic hospital date, all making it more difficult for Meredith to make a decision. With Burke's hand continuing to tremor, Cristina does her best to help him deal with his injury. As George and Callie's relationship continues to grow, Izzie attempts to visit the hospital for the first time since Denny's death. Meanwhile, Alex tends to a patient with numerous injuries.



40 :03x04 - What I Am

First aired: Oct/12/2006
Writer: Allan Heinberg
Director: Dan Lerner
Guest star: Chris O'Donnell (Finn Dandridge), Fred Ward (Denny Duquette, Sr.), Steven W. Bailey (Joe), Stephanie Faracy (Mrs. Sullivan), Tina Holmes (Rebecca Bloom), Alan Blumenfeld (Shawn Sullivan), Jeff Rubino (Jeff Bloom), Paula Weston Solano (OR Nurse), Jeffrey Dean Morgan (Denny Duquette)

As Addison works with Rebecca, a pregnant woman who needs to have a C-section but wants to give birth naturally, she begins to doubt her abilities as a doctor. The interns work with Shawn Sullivan, a car salesman who wants to return to his normal routine after he has surgery. However, when Shawn lights a cigarette that catches his face on fire, Derek and Mark argue over how they should procede with his burn treatment. Meanwhile, Burke continues to rehab his injured hands with the help of Cristina, gradually progressing from operating on chickens to operating on a corpse. Meredith goes into surgery after her appendix bursts and after surgery, she finally makes a decision between Derek and Finn. Elsewhere, Callie and George continue to discuss their relationship and Izzie meets a man who gives her the surprise of her life.



41 :03x05 - Oh, The Guilt

First aired: Oct/19/2006
Writer: Zoanne Clack, Tony Phelan, Joan Rater
Director: Jeff Melman
Guest star: Justina Machado (Mrs. Nyles), Faith Prince (Eve), Chris Conner (Mr. Nyles), Margo Harshman (Jennifer), Todd Babcock (Dr. Matthew Savoy), Arye Gross (Adam), Rosemary Garris (Hospital Administrator), Moe Irvin (Nurse Tyler Christian), Kate Anthony (Nurse Kate), Karl T. Wright (Mediator), Libby Barnes (Dr. #1), Tom Ormeny (Dr. #2), Dennis Depew (Intern)

Bailey treats a young woman suffering from breast cancer while Derek begins to learn more about Addison and Mark's rekindled relationship. Meanwhile, the interns team up to defend a resident at a staff meeting, and Meredith and Addison stumble into an awkward situation with one another.



42 :03x06 - Let the Angels Commit

First aired: Nov/02/2006
Writer: Stacy McKee
Director: Jessica Yu
Guest star: Embeth Davidtz (Nancy), Edwin Hodge (Greg), Liza Lapira (Noel), Jillian Bach (Gretchen), Francesca P. Roberts (Mrs. Bird), Patricia Bethune (Nurse Ginger), Moe Irvin (Nurse Tyler Christian), Jeremy Rabb (Resident), Martin Yu (Resident)

Cristina gets the once in a lifetime opportunity to scrub in on a rare humpty-dumpty procedure, much to the envy of the other interns. Meanwhile, Alex begins to question his choice of surgical specialty and George and Addison work together to help Noelle, a woman pregnant with twins that are developing at different rates.



43 :03x07 - Where the Boys Are

First aired: Nov/09/2006
Writer: Mark Wilding
Director: Dan Minahan
Guest star: Steven W. Bailey (Joe), George Dzundza (Harold O'Malley), Kali Rocha (Sydney Heron), Clare Carey (Vicky), Alexandra Billings (Donna), Alexandra Holden (Jamie), Jim Parrack (Ted), Jack Yang (Walter)

The Seattle Grace men pack up and head out to the Seattle wilderness for a camping trip. Back at the hospital, Callie and Addison work together on a pregnant patient who slipped and broke her arm in the shower and Meredith helps Dr. Sloan with a unique sex reassignment surgery. Meanwhile, Bailey becomes increasingly suspicious of Cristina and Burke and decides to confront Cristina. Elsewhere, the interns treat a 9 year-old who swallowed Monopoly game pieces.



44 :03x08 - Staring at the Sun

First aired: Nov/16/2006
Writer: Harry Werksman, Gabrielle Stanton
Director: Jeff Melman
Guest star: George Dzundza (Harold O'Malley), Myndy Crist (Diane Hanson), Greg Pitts (Jerry O'Malley), Tim Griffin (Ronny O'Malley), Matt Winston (Frank Jeffries), Paul Cassell (John Hanson), Annie Campbell (Anna), Steven W. Bailey (Joe), Kate Burton (Ellis Grey), Ray Ford (Ray the Paramedic), Brooke Bryan (Mia), Martin Yu (Resident), Brad Sachs (Tech)

George's family comes to Seattle Grace when George's father hurts his clavicle, throwing George into a frenzy. However, George's worst fears about his father's hospital visit are realized when the test results come back abnormal. As Meredith strives to have a more positive outlook on life, Derek and Addison work on finding away to have a civil relationship once again. Meanwhile, Richard attempts to work things out between him and Adele.



45 :03x09 - From a Whisper to a Scream

First aired: Nov/23/2006
Writer: Kip Koenig
Director: Julie Ann Robinson
Guest star: George Dzundza (Harold O'Malley), Brooke Smith (Dr. Erica Hahn), Debra Monk (Louise O'Malley), Lois Smith (Mrs. Dickinson), Emy Coligado (Ms. Suko), Kate Anthony (Nurse Kate), Linda Klein (Nurse Linda)

The ER is taken over by a horrific car accident and the trauma caused by the accident pushes and challenges the interns. Elsewhere, Cristina begins to wonder if she's doing the right thing by helping Burke lie about his hand condition and Izzie pushes the boundaries of her probation.



46 :03x10 - Don't Stand So Close to Me

First aired: Nov/30/2006
Writer: Carolina Paiz
Director: Seith Mann
Guest star: Brooke Smith (Dr. Erica Hahn), Mandy Siegfried (Molly Thompson), George Dzundza (Harold O'Malley), Tim Griffin (Ronny O'Malley), Greg Pitts (Jerry O'Malley), Debra Monk (Louise O'Malley), Kate Burton (Ellis Grey), Mare Winningham (Susan Grey), Jason Sklar (Jake), Randy Sklar (Pete), Jennifer Aspen (Elaina), Linda Klein (Nurse Linda), Jack Axelrod (Really Old Man)

Burke and Cristina's relationship continues to be strained in the aftermath of Cristina revealing Burke's limitations due to the shooting. Meredith's half-sister, Molly Thompson, is admitted to Seattle Grace forcing Meredith to once again confront her emotions towards her father and sister. Meanwhile, Derek and Mark are forced to work together when two conjoined brothers come to the hospital to be separated.



47 :03x11 - Six Days (1)

First aired: Jan/11/2007
Writer: Krista Vernoff
Director: Greg Yaitanes
Guest star: George Dzundza (Harold O'Malley), Jeff Perry (Thatcher Grey), Debra Monk (Louise O'Malley), Greg Pitts (Jerry O'Malley), Tim Griffin (Ronny O'Malley), Mae Whitman (Heather Douglas), Judith Hoag (Rhada Douglas), Steven W. Bailey (Joe), Sarah Utterback (Nurse Olivia Harper), Moe Irvin (Nurse Tyler Christian), Rhomeyn Johnson (Manager), Jake Mailey (Uncle Jim), Michael James Thompson (Cousin Joe)

After George's father's heart operation, Mr. O'Malley heads back to the O.R. for another surgery for his cancer. As George continues to worry about his father, Meredith's father visits Seattle Grace in order to see his newborn granddaughter. Meanwhile, Meredith discovers that Derek is having trouble sleeping, which is no fault but her own. Elsewhere, the interns treat an angry 17 year-old girl with severe scoliosis who has a poor attitude towards the doctors due to the several surgeries she has endured during her life.



48 :03x12 - Six Days (2)

First aired: Jan/18/2007
Writer: Krista Vernoff
Director: Greg Yaitanes
Guest star: George Dzundza (Harold O'Malley), Jeff Perry (Thatcher Grey), Debra Monk (Louise O'Malley), Greg Pitts (Jerry O'Malley), Tim Griffin (Ronny O'Malley), Mae Whitman (Heather Douglas), Judith Hoag (Rhada Douglas), Steven W. Bailey (Joe), Moe Irvin (Nurse Tyler Christian), Rhomeyn Johnson (Manager), Patricia Bethune (Nurse Ginger)

Mr. O'Malley heads back to surgery in order for the doctors to operate on his cancer. Meredith deals with her emotions while her father is at Seattle Grace to visit his new granddaughter. Meanwhile, a woman has a breakdown at the hospital after having to give up something important to her. Elsewhere, Meredith continues to worry about Derek when he is unable to sleep.



49 :03x13 - Great Expectations

First aired: Jan/25/2007
Writer: Eric Buchman
Director: Michael Grossman
Guest star: Loretta Devine (Adele Webber), Rachel Boston (Rachel), Jessica Stroup (Jilly Miller), Joe Holt (Steve), Kathleen Mary Carthy (Mrs. Miller), Michael P. Byrne (Mr. Miller)

While rumors about the chief's retirement begin to fly among the hospital staff, Bailey pushes for the creation of a free clinic at Seattle Grace. George uses sex as a way to cope with the death of his father, which worries both Izzie and Callie. Meanwhile, The interns treat a woman diagnosed with stage 4 cancer who has a complex Puritan past and Callie and Cristina operate on a runner in order to save his legs. Later, one of the doctors receives a surprising proposal.



50 :03x14 - Wishin' and Hopin'

First aired: Feb/01/2007
Writer: Joan Rater, Tony Phelan
Director: Julie Ann Robinson
Guest star: Kate Burton (Ellis Grey), Sarah Utterback (Nurse Olivia Harper), Matt McTighe (Vincent), Jasmine Di Angelo (Kailey Hanson), Ronobir Lahiri (Mr. Hanson), Joyce Guy (Ms. Henry), Kate Anthony (Nurse Kate), Maile Flanagan (Lab Tech), Tony Adelman (Hurts When He Pees), Liz Montgomery (Coughing Lady), Amanda Collins (Marina), David J. Lee (Sprained Ankle)

With Izzie's inheritance money, Bailey and Izzie open the Seattle Grace free clinic and eagerly wait for their first patient. The lives of the doctors are put at risk when a patient's blood is found to be toxic. Meredith, Cristina and Izzie volunteer to risk their lives to save the woman after Derek and Burke's air-tight suits run out of battery. Meanwhile, Ellis, Meredith's Alzheimer's-stricken mother, has a change in her condition; George and Callie return to the hospital with surprising news; and Cristina gives Burke an answer to his proposal.



51 :03x15 - Walk On Water (1)

First aired: Feb/08/2007
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Elizabeth Reaser (Jane Doe), Kali Rocha (Sydney Heron), Kate Burton (Ellis Grey), Dean Norris (Rick's Friend), Kelly Wolf (Carly Height), Paul Perri (Rick's Friend), Preston James Hillier (Cop), Terrance Christopher Jones (Paramedic #7), Jeffrey Markle (Greg), Billy Mayo (Rick), Brian Chenoweth (Scared Guy), Danielle Kennedy (Angry Woman), Paul Norwood (Scared Guy #2), Madison Leisle (Lisa the Child), Yvans Jourdain (Businessman), Kim Delgado (Search & Rescue Guy #1), Terry Woodberry (Police Officer), John Cappon (Paramedic #2), Nicole Cummins (Paramedic #4), Pete Flynn (Paramedic #1)

A horrific ferry boat accident challenges the interns, as well as the rest of the hospital staff, both physically and mentally as they all near their breaking point. Chief Webber has to assemble and send out a team to the location of the accident to help save the few lives that were spared. On location, Alex tends to a woman who was crushed by a cement pylon. Meanwhile, Meredith looks out for a lost young girl and George searches frantically for a woman's young son.



52 :03x16 - Drowning on Dry Land (2)

First aired: Feb/15/2007
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Kyle Chandler (Dylan Young), Jeffrey Dean Morgan (Denny Duquette), Elizabeth Reaser (Jane Doe), Kali Rocha (Sydney Heron), Dean Norris (Rick's Friend), Kelly Wolf (Carly Height), Paul Perri (Rick's Friend), Madison Leisle (Lisa the Child), Billy Mayo (Rick), Danielle Kennedy (Angry Woman), Yvans Jourdain (Businessman), Jonah Bay (Hopeful Guy), Liza de Weerd (Woman), Mac Brandt (Paramedic #3), Tim Chiou (Paramedic #6), John Koyama (Search and Rescue #2), Marlon John (Search and Rescue #3), Akeem Smith (Young Man)

As the chaos surrounding the ferry boat accident continues, Derek frantically searches for Meredith, and is devastated when he finds her barely clinging to life. Cristina is also devastated when she learns about Meredith's condition. Meanwhile, emotions run high at Seattle Grace as family of the accident victims demand to know the status of their loved ones. In the midst of the trauma, Alex has trouble dealing with the death surrounding him; George searches for a missing 7 year-old boy; and Izzie is forced to take desperate measures to save the life of the man stuck under a car.



53 :03x17 - Some Kind of Miracle (3)

First aired: Feb/22/2007
Writer: Shonda Rhimes, Marti Noxon
Director: Adam Arkin
Guest star: Kyle Chandler (Dylan Young), Jeffrey Dean Morgan (Denny Duquette), Elizabeth Reaser (Jane Doe), Anna Maria Horsford (Nurse Liz Fallon), Kate Burton (Ellis Grey), Monica Keena (Bonnie), Kali Rocha (Sydney Heron), Sarah Utterback (Nurse Olivia Harper), Steven W. Bailey (Joe), Moe Irvin (Nurse Tyler Christian), David Downs (Man), Yvette Cruise (ICU Nurse), Billy Wood (Perfusionist)

While Meredith's life hangs in the balance, the interns each have to grapple with the reality that she may not make it. Derek refuses to give up hope that Meredith will pull through, but as time passes, Derek begins to slowly break down. Cristina takes the possibility of her death the hardest, and refuses to accept that it could happen. As Bailey and Chief Webber work to save Meredith's life, Meredith is visited by figures from her past, including Denny and Dylan Young, both of whom try to convince her not to die. Elsewhere, Addison and Alex continue to work with their pregnant Jane Doe, who has no memory of the ferry boat accident or her life prior it.



54 :03x18 - Scars and Souvenirs

First aired: Mar/15/2007
Writer: Debora Cahn
Director: James Frawley
Guest star: Shohreh Aghdashloo (Helen Crawford), Elizabeth Reaser (Jane Doe), Mare Winningham (Susan Grey), Jeff Perry (Thatcher Grey), James Gammon (Mr. Scofield), Roger Rees (Colin Marlowe), Rob Narita (Anesthesiologist)

The race for Chief of Surgery continues to heat up, especially when a new contender enters the race. Callie reveals a big secret to George, and when George ends up telling Meredith, Callie kicks him out, leaving George with no where to go except to Meredith's. Cristina and Burke's engagement suffers when a secret about one of Cristina's past relationships is revealed. Meanwhile, Derek treats an old friend; Alex and Jane Doe get closer; and Meredith has dinner with her father and step-mother.



55 :03x19 - My Favorite Mistake

First aired: Mar/22/2007
Writer: Chris Van Dusen
Director: Tamra Davis
Guest star: Hector Elizondo (Mr. Torres), Elizabeth Reaser (Jane Doe), Michael Boatman (Doug Kendry), Roger Rees (Colin Marlowe), Catherine Dent (Cathy Rogerson), Elisabeth Moss (Nina Rogerson), Judi Barton (Board Member)

George comes face-to-face with his father-in-law, but the circumstances of their meeting are less than perfect. Alex continues to tend to Jane Doe and helps her choose how the world will see her from here on. Meanwhile, the board interviews Chief of Surgery candidates, and everyone is stunned when Sloan emerges as a top candidate. Elsewhere, Izzie wrestles with the events of her drunken night with George.



56 :03x20 - Time After Time

First aired: Apr/19/2007
Writer: Stacy McKee
Director: Christopher Misiano
Guest star: Elizabeth Reaser (Jane Doe), Roger Rees (Colin Marlowe), Brent Jennings (Charles), Suzanne Cryer (Caroline Klein), Tim Hopper (Dustin Klein), Steven W. Bailey (Joe), Mare Winningham (Susan Grey), Dee Wallace Stone (Joan Waring), Melissa Fitzgerald (Social Worker), Marc Vann (Hematologist), Liv Hutchings (Hannah), Randy Thompson (Frank Waring), Kate Anthony (Nurse Kate), Zibby Allen (Nurse Zibby), Nichelle Hines (Young Woman), Craig Tsuyumine (TV Reporter)

When Izzie has to face her past, she turns to George for support and comfort. As Alex continues to work with Jane Doe, the two become more attached to each other. Meanwhile, Meredith and Derek begin to question their status while Cristina strives to repair her relationship with Burke despite her past history with Dr. Marlow that continues to damage their engagement.



57 :03x21 - Desire

First aired: Apr/26/2007
Writer: Mark Wilding
Director: Tom Verica
Guest star: Kali Rocha (Sydney Heron), Elizabeth Reaser (Jane Doe), Mitch Pileggi (Larry Jennings), Mary-Margaret Humes (Nancy Jennings), Rowena King (Celeste Newman), Ramon De Ocampo (James Benton), Stewart Skelton (Dr. Fischer)

As the interns study for and stress over their upcoming exam, the attendings suck up to the chairman of the board in order to become front runner for the Chief's position when he is admitted to the hospital as a patient. Meanwhile, Burke has a difficult time involving Cristina in the planning of their wedding, Addison and Alex get closer, and Derek begins to second guess his relationship with Meredith.



58 :03x22 - The Other Side of This Life (1)

First aired: May/03/2007
Writer: Shonda Rhimes
Director: Michael Grossman
Guest star: Taye Diggs (Dr. Sam Bennett), Paul Adelstein (Cooper), Amy Brenneman (Violet), Timothy Daly (Pete (as Tim Daly)), Merrin Dungey (Naomi), Chris Lowell (Dell), Tsai Chin (Helen), Stephanie Niznik (Carol), Jeff Perry (Thatcher Grey), Mare Winningham (Susan Grey), Diahann Carroll (Jane Burke), Elizabeth Reaser (Jane Doe), D. W. Moffett (Alan), Bellamy Young (Kathy), Raphael Sbarge (Paul), David Anders (Sam), Becky Wahlstrom (Lisa), Cameron Watson (Rick), Garrison Hershberger (Doug (as Gary Hershberger)), Parisa Fitz-Henley (Tammie), Shavon Kirksey (Maya), Mary Joy (Elevator Voice), Garon Grigsby (Keith), Jane Clark (Nurse), Trista Delamere (SGH Clinic Nurse), William B. Jackson (Old Man), Robin Hines (Cute Girl)

Addison, on leave from Seattle Grace, heads to Los Angeles to reconnect with old friends from med school. Back in Seattle, Meredith continues to bond with Susan, her step-mother, and Cristina, with the help of both her mother and Burke's mother, begins planning her wedding. Meanwhile, Derek performs emergency surgery on Ava (Jane Doe) and Alex continues to stand by her.



59 :03x23 - The Other Side of This Life (2)

First aired: May/03/2007
Writer: Shonda Rhimes
Director: Michael Grossman
Guest star: Taye Diggs (Dr. Sam Bennett), Paul Adelstein (Cooper), Amy Brenneman (Violet), Timothy Daly (Pete (as Tim Daly)), Merrin Dungey (Naomi), Chris Lowell (Dell), Tsai Chin (Helen), Mare Winningham (Susan Grey), Jeff Perry (Thatcher Grey), Stephanie Niznik (Carol), Bellamy Young (Kathy), Diahann Carroll (Jane Burke), Elizabeth Reaser (Jane Doe), Shavon Kirksey (Maya), Raphael Sbarge (Paul), David Anders (Sam), Becky Wahlstrom (Lisa), Cameron Watson (Rick), Garrison Hershberger (Doug (as Gary Hershberger)), Mary Joy (Elevator Voice), Garon Grigsby (Keith), Jane Clark (Nurse), Trista Delamere (SGH Clinic Nurse), William B. Jackson (Old Man), Robin Hines (Cute Girl)

In the conclusion to part 1, Addison visits Los Angeles and continues to reconnect with her old medical school friends. In Seattle, Meredith gets closer to her step mother. Cristina deals with the pressures of her pending marriage, and reluctantly plans the wedding with her mother and future mother-in-law. Meanwhile, Derek operates on Ava.



60 :03x24 - Testing 1-2-3

First aired: May/10/2007
Writer: Allan Heinberg
Director: Christopher Misiano
Guest star: Loretta Devine (Adele Webber), Elizabeth Reaser (Jane Doe), Steven W. Bailey (Joe), Jeff Perry (Thatcher Grey), Mandy Siegfried (Molly Thompson), Aasha Davis (Rina), Kevin Rankin (Jack), Brian Tee (Andy), Jack Yang (Walter), Derek Phillips (Dale), Chyler Leigh (Lexie Grey), Tim Chiou (Paramedic), Nicole Cummins (Paramedic Nicole), Michelle N. Carter (Proctor)

The interns face one of their biggest challenges yet -- their first-year medical exams. Meanwhile, the interns must tend to three injured mountain climbers. Elsewhere, Callie becomes increasingly suspicious of George and Izzie and Cristina has trouble writing her vows.



61 :03x25 - Didn't We Almost Have It All

First aired: May/17/2007
Writer: Joan Rater, Tony Phelan
Director: Rob Corn
Guest star: Elizabeth Reaser (Jane Doe), Loretta Devine (Adele Webber), Diahann Carroll (Jane Burke), Chyler Leigh (Lexie Grey), Jason London (Jeff Pope), Steven W. Bailey (Joe), Tsai Chin (Helen), Aasha Davis (Rina), Kevin Rankin (Jack), Brian Tee (Andy), Jack Yang (Walter), Derek Phillips (Dale), Robin Pearson Rose (Patricia), Ajay Vidure (Intern #1), Candice Afia (Intern #2), Artie O'Daly (Intern #3), Joseph Williamson (Intern #4), Traber Burns (Andy's Lawyer)

A big day arrives for all -- Cristina and Burke's wedding and the interns receive their exam results. Meanwhile, Chief Webber's replacement is named and George and Callie make a decision about their relationship.



Come Rain or Shine

First aired: Sep/19/2007

"Come Rain or Shine: From Grey's Anatomy to Private Practice" goes into the life of Dr. Addison Montgomery as she transitions from Seattle Grace to Oceanside in the new spin-off Private Practice. The episode also includes the premiere of the Grey's Anatomy music video featuring "Breath In Breath Out," a song by Mat Kearney. The video features clips from the previous three seasons and the episode will feature a glimpse at the new season of Grey's Anatomy.



62 :04x01 - A Change Is Gonna Come

First aired: Sep/27/2007
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Tymberlee Chanel (Claire), Gloria Garayua (Intern Graciella), Richard Keith (Mitch Greenberg), Mark Pellegrino (Chris), Sandra Thigpen (Clara), Stephanie Childers (Nancy), Steven M. Porter (Joey), Candice Afia (Intern Laura), Amrapali Ambegaokar (Intern Dani), Molly Kidder (Intern Megan), Joy Osmanski (Intern Lucy), Winston Story (Intern Leo), Joseph Williamson (Intern Pierce)

Meredith and Cristina return from Cristina's honeymoon to find that Burke is long gone. Izzie, Alex, Meredith and Cristina start their first day as residents, each with their own set of interns. Among the interns are George, who is repeating his internship after failing the exam, and Lexie, Meredith's half-sister. Meanwhile, Derek begins to look elsewhere after his relationship with Meredith hits an emotional impasse; Bailey grapples with the fact that her former interns now report to Callie, the new Chief Resident; and Richard returns to his position as Chief of Surgery.



63 :04x02 - Love/Addiction

First aired: Oct/04/2007
Writer: Debora Cahn
Director: James Frawley
Guest star: Diahann Carroll (Jane Burke), Ben Vereen (Archie), Brendan Elliott (Dave), Nicholas Gonzalez (Clark), Amy Landers (Marla Krestler), Tanya Linette Smith (Jennifer), Moe Irvin (Nurse Tyler Christian), Brooke Blanchard (Jill the Paramedic), Ray Ford (Ray the Paramedic), Candice Afia (Intern Laura), Amrapali Ambegaokar (Intern Dani), Mark Saul (Intern Steve), Joseph Williamson (Intern Pierce)

The interns and residents treat victims of an apartment complex explosion as Alex looks into the cause of the devastating accident. Mama Burke arrives at Seattle Grace to pick up the rest of Burke's personal things while Cristina trades wedding gifts for surgeries. Meanwhile, Lexie tries to talk to Meredith, who is less than willing to do so; Callie deals with the stress of being Chief Resident; and Bailey tries to figure out what to do with her excess leadership skills.



64 :04x03 - Let the Truth Sting

First aired: Oct/11/2007
Writer: Mark Wilding
Director: Dan Minahan
Guest star: Edward Herrmann (Norman), Caroline Aaron (Connie), Eve Gordon (Mary), Amy Hill (Joanne), Debra Christofferson (Elaine), Jack Axelrod (Really Old Guy (Charlie)), Martin Spanjers (Hunter Chapman), Moe Irvin (Nurse Tyler Christian), Ray Ford (Ray the Paramedic), Linda Eve Miller (ER Nurse), Candice Afia (Intern Laura), Amrapali Ambegaokar (Intern Dani), Tymberlee Chanel (Intern Claire), Gloria Garayua (Intern Graciella), Richard Keith (Intern Mitch), Molly Kidder (Intern Megan), Joy Osmanski (Intern Lucy), Mark Saul (Intern Steve), Joseph Williamson (Intern Pierce), Winston Story (Intern Leo), Alison Crowley (Clinic Nurse), Peter Smith (Clinic Nurse)

The new interns are in awe of fellow intern George's skill level, and Lexie tries to keep his "repeater" status secret. Meredith comes to Lexie's aide when Lexie is faced with her first emergency situation. The Chief and Sloan have to use a radical surgery to save a woman's vocal ability. Meanwhile, George debates telling Callie about his affair with Izzie.



65 :04x04 - The Heart of the Matter

First aired: Oct/18/2007
Writer: Allan Heinberg
Director: Randall Zisk
Guest star: Edward Herrmann (Norman), Michael McGrady (Stanley), Matt Lanter (Adam), Maggie Siff (Ruthie), Miriam Flynn (Ms. Bitzer), Camille Winbush (Camille), Ron Melendez (Will), Loretta Devine (Adele Webber), Shelley Robertson (Arlene), Jeremy Rabb (ER Doctor), Maile Flanagan (Lab Tech), Tymberlee Chanel (Intern Claire), Gloria Garayua (Intern Graciella), Richard Keith (Intern Mitch), Molly Kidder (Intern Megan), Joy Osmanski (Intern Lucy), Mark Saul (Intern Steve), Winston Story (Intern Leo), Cassandra Braden (Housekeeping Staffer), Nicole Cummins (Paramedic)

Izzie reveals her true feelings for George to one of her and George's friends, and the reaction she receives is not what she expected. Meanwhile, Adele Webber rushes her niece to Seattle Grace; Derek gives Cristina pointers on how to be a better teaching resident; and Norman, the world's oldest intern, misdiagnoses Meredith's patient.



66 :04x05 - Haunt You Every Day

First aired: Oct/25/2007
Writer: Krista Vernoff
Director: Bethany Rooney
Guest star: Edward Herrmann (Norman), Elizabeth Reaser (Ava), Rocky Carroll (James), Kali Rocha (Sydney Heron), David Clennon (Jack), Dylan Minnette (Ryan), Sarah Utterback (Nurse Olivia Harper), Anjul Nigam (Raj), Bhama Roget (Erin), Crystal Kwon (Nurse Jolene), Jeremiah Hu (Fingerless Guy), Ray Ford (Ray the Paramedic), Linda Eve Miller (ER Nurse), Suzanne Quinn (Clinic Nurse)

It's Halloween at Seattle Grace and the day is chock-full of surprises for the doctors. Alex has a surprise visit from a former patient; Meredith thinks her mother's ashes are haunting her; Cristina is snubbed by a top surgeon; and everyone is shocked when Callie reveals George and Izzie's relationship to the public.



67 :04x06 - Kung Fu Fighting

First aired: Nov/01/2007
Writer: Stacy McKee
Director: Tom Verica
Guest star: David Denman (Rick), Cullen Douglas (Mr. Arnold), Marina Black (Sally), Tommy Dewey (Mike), Amanda Loncar (Jackie), Steve Sandvoss (Jason), Chryssie Whitehead (Helena)

With his marriage once again falling apart, Chief Webber invites the male surgeons out on a "gentleman's evening." Meanwhile, Cristina and Izzie compete for the same surgeries, mainly to impress the doctor performing them; Meredith treats the survivor of a skydiving accident; and two finalists competing in a promotional competition are treated by the doctors.



68 :04x07 - Physical Attraction... Chemical Reaction

First aired: Nov/08/2007
Writer: Joan Rater, Tony Phelan
Director: Jeff Melman
Guest star: Jeff Perry (Thatcher Grey), Rockmond Dunbar (Sean), Stephanie March (Jane), Vicki Lewis (Harriet), David Burke (Don), Kurt Fuller (Jerry), Enuka Okuma (Teresa)

George and Izzie's relationship is tested, as is Derek and Meredith's when Derek wants more than a physical relationship with her. Meanwhile, Mark falls for a surgeon and Callie's position as Chief Resident is put on the line when she gives too many duties to Bailey.



69 :04x08 - Forever Young

First aired: Nov/15/2007
Writer: Mark Wilding
Director: Rob Corn
Guest star: Jeff Perry (Thatcher Grey), Kali Rocha (Sydney Heron), D. B. Woodside (Marcus), Lauren Stamile (Rose), Madeline Zima (Marissa), Brooke Nevin (Tricia), Stephen Sowan (Danny), Andrea Vercetti (Marissa)

The ER is thrown into a state of chaos following a school bus accident. Meanwhile, Bailey treats her high school crush; Derek goes on a date; and Thatcher comes to Seattle Grace in search of Meredith.



70 :04x09 - Crash Into Me (1)

First aired: Nov/22/2007
Writer: Shonda Rhimes, Krista Vernoff
Director: Michael Grossman
Guest star: Seth Green (Nick), Elizabeth Reaser (Ava), Lauren Stamile (Rose), Cress Williams (Tucker), Gale Harold (Shane), John Billingsley (Jacob), Theo Rossi (Stan), Kimberly Huie (Mary Daltren), Alison La Placa (Jacob's Wife), Ray Ford (Ray the Paramedic), Shanelle Gray (Sara), Mark Saul (Intern Steve), Joseph Williamson (Intern Pierce), Candice Afia (Intern Laura), Joy Osmanski (Intern Lucy), Crystal Kwon (Nurse Jolene), Roger Bridges (Firefighter), Nick Hoffa (Firefighter #2), Emma Prescott (Lucy), Suzi Holrichter (Sandra), Parker Goris (Garrett), Linda Klein (Nurse Linda)

Meredith and the Chief rush to the scene of a devastating ambulance crash in which the lives of the paramedics are at stake. Bailey treats a difficult patient and Ava returns to find Alex with a new girlfriend.



71 :04x10 - Crash Into Me (2)

First aired: Dec/06/2007
Writer: Krista Vernoff, Shonda Rhimes
Director: Jessica Yu
Guest star: Elizabeth Reaser (Ava), Seth Green (Nick), Cress Williams (Tucker), Lauren Stamile (Rose), Gale Harold (Shane), Moe Irvin (Nurse Tyler Christian), Ray Ford (Ray the Paramedic), Theo Rossi (Stan)

In the conclusion to the two-part episode arc, Meredith races to save the life of a paramedic, who is trapped inside an ambulance. Meanwhile, the life of a patient is in Lexie's hands and Derek and a nurse work together to save the life of a patient.



72 :04x11 - Lay Your Hands on Me

First aired: Jan/10/2008
Writer: Allan Heinberg
Director: John Terlesky
Guest star: Glenne Headly (Elizabeth), Debra Monk (Louise O'Malley), Cress Williams (Tucker), Lauren Stamile (Rose), Carol Locatell (Mai)

Bailey's family faces a medical trauma, just as her marriage is falling apart, a surprise visit from George's mother comes as a shock to both Izzie and Callie, a faith healer challenges Erica and Alex's beliefs in traditional medicine, and Derek must deal with the aftermath of his kiss with Rose.



73 :04x12 - Where The Wild Things Are

First aired: Apr/24/2008
Writer: Zoanne Clack
Director: Rob Corn
Guest star: Lauren Stamile (Rose), Amy Madigan (Dr. Wyatt), Cheech Marin (Otis), Clea DuVall (Jennifer), Steven Flynn (Scott), Jason O'Mara (Phillip), Troy Westbrook (Paramedic)

Six weeks following Derek and Meredith's break-up, Derek continues to date Rose while Meredith, Alex, Izzie and Cristina compete in a surgical contest. Meanwhile, George and Lexie adjust to their new apartment and Callie finds a new friend in Erica Hahn.



74 :04x13 - Piece of My Heart

First aired: May/01/2008
Writer: Stacy McKee
Director: Mark Tinker
Guest star: Kate Walsh (Addison Montgomery), Amy Madigan (Dr. Wyatt), Elizabeth Reaser (Rebecca), Clea DuVall (Jennifer), Lauren Stamile (Rose), Kathleen Rose Perkins (Sarah), Ken Barnett (Freddie), Jason O'Mara (Phillip), Sam Daly (Will), Meg Cionni (Nikki), John O'Brien (Lab Tech), Gloria Garayua (Intern Graciella), Tymberlee Chanel (Intern Claire), Winston Story (Intern Leo), Joy Osmanski (Intern Lucy), Molly Kidder (Intern Megan), Richard Keith (Intern Mitch)

Addison makes her return to Seattle Grace in order to perform an operation. As she does so, she is preoccupied by all of the changes in her former co-workers' lives. Meanwhile, Meredith and Derek's clinical trial has its first patient, and Rebecca returns to deliver Alex some shocking news.



75 :04x14 - The Becoming

First aired: May/08/2008
Writer: Tony Phelan, Joan Rater
Director: Julie Ann Robinson
Guest star: Lauren Stamile (Rose), John M. Jackson (Kevin), Benny Ciaramello (Darren), Zilah Mendoza (Kyra), Dave Giuntoli (Todd), Loretta Devine (Adele Webber), Amy Madigan (Dr. Wyatt)

The nurses' outcry over McSteamy's frequent trysts leads the hospital to enact a new "date and tell" policy. Meanwhile, news about Burke's career force Cristina to cope with her feelings about the past; Meredith and Derek take in a veteran soldier to participate in their clinical trial; and Callie finds comfort in Sloane when she needs it the most.



76 :04x15 - Losing My Mind

First aired: May/15/2008
Writer: Debora Cahn
Director: James Frawley
Guest star: Amy Madigan (Dr. Wyatt), Lauren Stamile (Rose), Elizabeth Reaser (Rebecca), Regina Taylor (Greta)

As Dr. Wyatt refuses to let Meredith give up on her therapy sessons, Alex learns the truth about Rebecca's condition. Chief Webber has Dr. Hahn perform a high-risk surgery on his mentor. Meanwhile, after hearing about Burke, Cristina continues to act unusually, going as far as to clean her ever-messy apartment.



77 :04x16 - Freedom (1)

First aired: May/22/2008
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Elizabeth Reaser (Rebecca), Amy Madigan (Dr. Wyatt), Lauren Stamile (Rose), Jurnee Smollett (Beth), John Cothran, Jr. (Ken), Jana Kramer (Lola)

In the two-part season finale, Meredith and Derek take another shot at the clinical trial while the others race to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for Rebecca and Lexie learns a secret about George's intern status.



78 :04x17 - Freedom (2)

First aired: May/22/2008
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Amy Madigan (Dr. Wyatt), Elizabeth Reaser (Rebecca), Lauren Stamile (Rose), Loretta Devine (Adele Webber), Jurnee Smollett (Beth), John Cothran, Jr. (Ken)

In the two-part season finale, Meredith and Derek take another shot at the clinical trial while the others race to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for Rebecca and Lexie learns a secret about George's intern status.



79 :05x01 - Dream a Little Dream of Me (1)

First aired: Sep/25/2008
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Lauren Stamile (Rose), Kevin McKidd (Owen Hunt), Mariette Hartley (Betty), Cliff DeYoung (Phil), Bernadette Peters (Sarabeth), Kathy Baker (Anna), John Getz (Michael)

As Meredith and Derek begin to find that their "happily ever after" is anything but easy, Cristina develops a crush on a military doctor who brings in a trauma patient. Meanwhile, the Chief and his staff cope with the news that Seattle Grace is no longer considered a top-tier teaching hospital.



80 :05x02 - Dream a Little Dream of Me (2)

First aired: Sep/25/2008
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Kevin McKidd (Owen Hunt), Mariette Hartley (Betty), Lauren Stamile (Rose), Cliff DeYoung (Phil), Bernadette Peters (Sarabeth), Kathy Baker (Anna), John Getz (Michael)

While Meredith and Derek continue in their new relationship, Cristina continues to get to know the military doctor as they treat his trauma patient.



81 :05x03 - Here Comes the Flood

First aired: Oct/09/2008
Writer: Krista Vernoff
Director: Michael Pressman
Guest star: Amy Madigan (Dr. Wyatt), Daniel J. Travanti (Barry), Jim Ortlieb (Jack), Samantha Quan (Shelly), Suzy Nakamura (Jenn)

When the plumbing springs a leak, chaos breaks out at Seattle Grace as the Chief tries to put in place new teaching methods. Meanwhile, George takes his residency exam; and Derek attempts to get Meredith's roommates to move out, much to their surprise.



82 :05x04 - Brave New World

First aired: Oct/16/2008
Writer: Debora Cahn
Director: Eric Stoltz
Guest star: Amy Aquino (Marianne), Larry Brandenburg (Arnie), Bre Blair (Lauren), John Sloan (David), Steven W. Bailey (Joe), Kathleen Early (Dr. Daisy Pepman), Max Burkholder (Duncan)

Meredith is sent into a state of panic when Derek finds her mother's diary in the house. Meanwhile, Callie stresses while preparing for her first date with Erica. Later, Cristina stumbles across a part of the hospital no one has ever seen before.



83 :05x05 - There's No 'I' in Team

First aired: Oct/23/2008
Writer: Jenna Bans
Director: Randall Zisk
Guest star: Kevin McKidd (Owen Hunt), Carl Lumbly (Kurt), George Newbern (Stan), Colleen Flynn (Nancy), Saige Thompson (Lindsay), Leslie Odom, Jr. (PJ), Steven W. Bailey (Joe)

Bailey leads a team for a "domino procedure" in which each surgery is dependent on the one before it. Meanwhile, Derek receives sole credit for the study he and Meredith worked on; Lexie tries to get George to see her in a different light; and Sloan gives Callie relationship advice.



84 :05x06 - Life During Wartime

First aired: Oct/30/2008
Writer: Mark Wilding
Director: James Frawley
Guest star: Kevin McKidd (Owen Hunt), Scott Haven (Randy), Lauri Johnson (Grandma Ruth), Brandon Scott (Intern Ryan), Adair Tishler (Tori Begler)

The Chief gives Bailey new responsibility in order to help her to be one of the best surgeons at Seattle Grace. Meanwhile, Owen Hunt, the new head of trauma, clashes with the current staff's methods and abilities.



85 :05x07 - Rise Up

First aired: Nov/06/2008
Writer: William Harper
Director: Joanna Kerns
Guest star: Jeffrey Dean Morgan (Denny Duquette), Kevin McKidd (Owen Hunt), Bonnie Bartlett (Rosie Bullard), Avery Clyde (Elyse), Gloria Garayua (Intern Graciella), Mark Saul (Intern Steve), Fidel Gomez (Morgue Attendant), Shi Ne Nielson (Paramedic), Gordon James (Tech)

When the Chief makes an announcement that a solo surgery is up as an award, the residents are sent into a frenzy all trying to get an edge over one another. Meanwhile, Derek asks Bailey for advice after Cristina continues to interfere in his relationship with Meredith. Elsewhere, Erica uncovers a shocking connection between a resident and a patient.



86 :05x08 - These Ties That Bind

First aired: Nov/13/2008
Writer: Stacy McKee
Director: Eric Stoltz
Guest star: Jeffrey Dean Morgan (Denny Duquette), Kevin McKidd (Owen Hunt), Melissa George (Sadie), Mary McDonnell (Virginia Dixon), August Schellenberg (Clay Bedonie), Ed Lauter (Garbage Truck Homeless Guy)

Sadie, one of Meredith's oldest friends, is brought on as an intern at Seattle Grace; however, Meredith's friends are less than welcoming to her. Meanwhile, Lexie leads the interns on a unique training session; and Virginia, a new surgeon, brings new rules to the O.R.



87 :05x09 - In the Midnight Hour

First aired: Nov/20/2008
Writer: Joan Rater, Tony Phelan
Director: Tom Verica
Guest star: Jeffrey Dean Morgan (Denny Duquette), Kevin McKidd (Owen Hunt), Melissa George (Sadie), Leslie Grossman (Lauren), Joshua Malina (Seth), John Allen Nelson (Arthur), Madeline Carroll (Ivy), Brandon Scott (Intern Ryan), Joseph Williamson (Intern Pierce), Gloria Garayua (Intern Graciella), Mark Saul (Intern Steve), Molly Kidder (Intern Megan), Winston Story (Intern Leo), Jody Sclavos (ER Nurse), Nicole Cummins (EMT)

Meredith, Cristina and Bailey must save Lexie and Sadie after a routine surgery goes terribly awry. Meanwhile, Owen and Derek treat a man injured while sleepwalking.



88 :05x10 - All By Myself

First aired: Dec/04/2008
Writer: Peter Nowalk
Director: Arlene Sanford
Guest star: Kevin McKidd (Owen Hunt), Melissa George (Sadie), Mary McDonnell (Virginia Dixon), Larkin Campbell (Mr. Anderson), Perry Smith (Mrs. Anderson), Gloria Garayua (Intern Graciella), Mark Saul (Intern Steve), Zibby Allen (Nurse), Keeshan Giles (Paramedic #2)

Cristina wins the first solo surgery among the residents, but is forced to give it up and choose who will perform the surgery in her place. Meanwhile, Mark heads up a procedure that will allow his patient to regain their ability to speak. Elsewhere, Callie tries to figure out if Sadie is being friendly to her or hitting on her.



89 :05x11 - Wish You Were Here

First aired: Jan/08/2009
Writer: Debora Cahn
Director: Rob Corn
Guest star: Jeffrey Dean Morgan (Denny Duquette), Kevin McKidd (Owen Hunt), Eric Stoltz (William), Jessica Capshaw (Dr. Arizona Robbins), Samantha Mathis (Melinda), Perrey Reeves (Margaret), Steven W. Bailey (Joe), Robin Pearson Rose (Patricia), Melissa George (Sadie), Aaron Refvem (Jackson), John Sloman (Dr. Kinley), Gloria Garayua (Intern Graciella), Molly Kidder (Intern Megan), Candice Afia (Intern Laura), Amrapali Ambegaokar (Intern Dani), Kevin Clarke (Paramedic)

Bailey pairs up with Dr. Arizona Robbins, Seattle Grace's new pediatric surgeon, to help save the life of a young patient. Derek is furious when a death row inmate is checked in to the hospital; Cristina and Meredith's friendship continues to erode; Callie and Sloan work through their attractions to Sadie and Lexie; and Izzie confesses to Alex that she has been seeing Denny.



90 :05x12 - Sympathy for the Devil

First aired: Jan/15/2009
Writer: Jenna Bans
Director: Jeannot Szwarc
Guest star: Jeffrey Dean Morgan (Denny Duquette), Tyne Daly (Carolyn), Kevin McKidd (Owen Hunt), Melissa George (Sadie), Eric Stoltz (William), Jessica Capshaw (Dr. Arizona Robbins), Samantha Mathis (Melinda), Jason Kravits (Chuck), Ernie Grunwald (Gary), Brandon Scott (Intern Ryan)

Derek's mother, Carolyn, makes a surprise visit and meets Meredith for the first time. Meanwhile, Mark tries to hide his relationship with Lexie; William, the death row inmate, asks to donate his organs to Bailey's patient; and Owen and Cristina go on their first date.



91 :05x13 - Stairway to Heaven

First aired: Jan/22/2009
Writer: Mark Wilding
Director: Allison Liddi
Guest star: Jeffrey Dean Morgan (Denny Duquette), Kevin McKidd (Owen Hunt), Melissa George (Sadie), Eric Stoltz (William), Jessica Capshaw (Dr. Arizona Robbins), Samantha Mathis (Melinda), Jason Kravits (Chuck), Ernie Grunwald (Gary), Brandon Scott (Intern Ryan)

Bailey becomes desperate as her patient's condition rapidly worsens, causing everyone to work to find the boy an organ donor before it's too late. Meanwhile, Mark finds himself in a compromising position and Crisitina avoids Owen.



92 :05x14 - Beat Your Heart Out

First aired: Feb/05/2009
Writer: William Harper
Director: Julie Ann Robinson
Guest star: Jessica Capshaw (Dr. Arizona Robbins), Jennifer Westfeldt (Jen), Ben Shenkman (Rob), Peter MacKenzie (Warren), Laura Allen (Beth), Brandon Scott (Intern Ryan), Mary McDonnell (Dr. Dixon), Melissa George (Sadie)

With the engagement ring taken care of, Derek ponders the perfect way to pop the question to Meredith. Meanwhile, Lexie demands that Mark go public with their relationship; and Bailey, happy with her work with recent patients, considers a new career direction.



93 :05x15 - Before and After

First aired: Feb/12/2009
Writer: Tony Phelan, Joan Rater
Director: Daniel Attias
Guest star: Kate Walsh (Addison Montgomery), Audra McDonald (Naomi), Taye Diggs (Dr. Sam Bennett), Grant Show (Archer), Jennifer Westfeldt (Jen), Ben Shenkman (Rob), Laura Allen (Beth), Sam Anderson (Michael), Steven W. Bailey (Joe), Brandon Scott (Intern Ryan), Melissa George (Sadie)

Addison, Naomi and Sam bring Archer to Seattle Grace in order to have Derek and Mark work to save his life. Meanwhile, Izzie works on a medical game to help the interns.



94 :05x16 - An Honest Mistake

First aired: Feb/19/2009
Writer: Peter Nowalk
Director: Randall Zisk
Guest star: Kate Walsh (Addison Montgomery), Faye Dunaway (Dr. Campbell), Brandon Scott (Intern Ryan), Jessica Capshaw (Dr. Arizona Robbins), Gloria Garayua (Intern Graciella), Mark Saul (Intern Steve), Joy Osmanski (Intern Lucy), Winston Story (Intern Leo), Molly Kidder (Intern Megan), Jennifer Westfeldt (Jen), Ben Shenkman (Rob), Kathleen Early (Dr. Daisy Pepman), Louis Giambalvo (John), Susan Merson (Lorraine)

Derek's confidence is dashed as he squares off with Addison over a patient. Cristina begins to doubt the abilities of a surgeon after she messes up on a routine procedure. Meanwhile, Bailey, pursuing a fellowship in pediatrics, is appalled by the Chief's recommendation letter.



95 :05x17 - I Will Follow You Into the Dark

First aired: Mar/12/2009
Writer: Jenna Bans
Director: Rob Corn
Guest star: Jessica Capshaw (Dr. Arizona Robbins), Michael Rady (Mike Shelley), Wendy Hoopes (Tricia), Erin Cahill (Meg), Susane Lee (Beth), Brandon Scott (Intern Ryan), Loretta Devine (Adele Webber), Phil Abrams (Dr. John Nelson), B.K. Cannon (Girl Band Geek), Marcus McGee (Boy Band Geek), Mark Saul (Intern Steve), Gloria Garayua (Intern Graciella), Candice Afia (Intern Laura), Amrapali Ambegaokar (Intern Dani), Tymberlee Chanel (Intern Claire), Molly Kidder (Intern Megan), Joseph Williamson (Intern Pierce), Winston Story (Intern Leo)

When Derek learns that more of his patients have died than survived, he decides to quit despite Meredith standing by him. Meanwhile, Bailey and the Chief continue to fail to see eye-to-eye on the fellowship until Adele steps in. Elsewhere, Izzie's interns discover dire news in regards to "patient x," unaware it's Izzie.



96 :05x18 - Stand By Me

First aired: Mar/19/2009
Writer: Zoanne Clack
Director: Jessica Yu
Guest star: Larry Sullivan (Dave), Emily Kuroda (Kendall), Brandon Scott (Intern Ryan), Candice Afia (Intern Laura), Darcy Martin (Sharon), Greta Sesheta (TBA), Michael Merton (Dexter), Mark Saul (Intern Steve), Candace Brown (Milo), Amrapali Ambegaokar (Intern Dani), Tymberlee Chanel (Intern Claire), Molly Kidder (Intern Megan), Joseph Williamson (Intern Pierce), Winston Story (Intern Leo), Martin Yu (Anesthesiologist)

As Izzie continues to hide her medical secret, the residents all try to convince Derek to come back to work but fail at doing so. Meanwhile, Mark attempts a radical face transplant surgery; and Cristina is awarded a solo surgery, but is preoccupied by Izzie's condition.



97 :05x19 - Elevator Love Letter

First aired: Mar/26/2009
Writer: Stacy McKee
Director: Edward Ornelas
Guest star: Jessica Capshaw (Dr. Arizona Robbins), Kimberly Elise (Dr. Swender), Molly Hagan (Jackie), Todd Waring (Tobin), Brandon Scott (Dr. Ryan Spalding)

Tensions are high as Derek returns to Seattle Grace to perform his first surgery following his breakdown. Meanwhile, everyone turns their attention to Izzie, who must undergo surgery for her condition; and Owen suffers from another PTSD episode that injures Cristina, putting their relationship at risk.



98 :05x20 - Sweet Surrender

First aired: Apr/23/2009
Writer: Sonay Washington
Director: Tony Phelan
Guest star: Obba Babatundé (Gates), Jose Zuniga (Meloy), Elden Henson (Mr. Smithson), Kimberly Elise (Dr. Swender), Jessica Capshaw (Dr. Arizona Robbins), Hector Elizondo (Mr. Torres), Amy Madigan (Dr. Wyatt)

As she endures aggressive treatment for her cancer, Izzie throws herself into planning Derek and Meredith's wedding.



99 :05x21 - No Good at Saying Sorry (One More Chance)

First aired: Apr/30/2009
Writer: Krista Vernoff
Director: Tom Verica
Guest star: Jeff Perry (Thatcher Grey), Kellie Martin (Julie), Megan Henning (Willow), Sharon Lawrence (Robbie), Jessica Capshaw (Dr. Arizona Robbins), Nina Siemaszko (Kate)

As Meredith and Derek continue to prepare for their wedding day, Izzie receives a surprise visit from her mother, and a person from Meredith and Lexie's past arrives at Seattle Grace.



100 :05x22 - What a Difference a Day Makes

First aired: May/07/2009
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: Jeffrey Dean Morgan (Denny Duquette), Jessica Capshaw (Dr. Arizona Robbins)

As Meredith, Derek and their friends and family gather for their wedding, a group of several college students are admitted to the E.R. following a car crash.



101 :05x23 - Here's to the Future (1)

First aired: May/14/2009
Writer: Allan Heinberg
Director: Bill D'Elia
Guest star: Jeffrey Dean Morgan (Denny Duquette), Debra Mooney (Mrs. Hunt), Zach Gilford (Charlie), Liza Weil (TBA), Jessica Capshaw (Dr. Arizona Robbins), Kimberly Elise (Dr. Swender)

After spending time with a fellow cancer patient, Izzie begins to question whether or not to undergo a risky procedure. Meanwhile, Mark considers taking his relationship with Lexie to the next level; and after helping a patient, Owen begins to rethink his position at Seattle Grace.



102 :05x24 - Now or Never (2)

First aired: May/14/2009
Writer: Debora Cahn
Director: Rob Corn
Guest star: Shannon Lucio (Amanda), Jessica Capshaw (Dr. Arizona Robbins), Kimberly Elise (Dr. Swender)

George gives Bailey news that shocks the entire hospital as everyone awaits for Izzie to recover from surgery. Meanwhile, Bailey is accepted into the pediatric fellowship program; and Seattle Grace comes together to help save a traffic accident victim.



103 :06x01 - Good Mourning (1)

First aired: Sep/24/2009
Writer: Krista Vernoff
Director: Edward Ornelas
Guest star: Shannon Lucio (Amanda), Debra Monk (Louise O'Malley), Mitch Pileggi (Larry Jennings), Tymberlee Chanel (Intern Claire), Mark Saul (Intern Steve), Molly Kidder (Intern Megan), Joseph Williamson (Intern Pierce), Winston Story (Intern Leo), Gloria Garayua (Intern Graciella), Tony Casale (ND Surgeon #2), Alicia Hannah (Jasmine), Jim Metzler (Priest), Emily Roche (Jo), Payton Silver (Dr. Knox), Lori Yeghiayan (ND Surgeon #1), Ray Ford (Ray the Paramedic), Martha Plimpton (Pam), Zoe Boyle (Clara), Zack Shada (Andy)

The Seattle Grace staff has to deal with the aftermath of George's tragic death. As the news hits the staff hard, they all must find a way to get through the stages of grief. Later, George's mother arrives at the hospital to decide what to do with his organs.



104 :06x02 - Goodbye (2)

First aired: Sep/24/2009
Writer: Krista Vernoff
Director: Edward Ornelas
Guest star: Amy Madigan (Dr. Wyatt), Martha Plimpton (Pam), Mitch Pileggi (Larry Jennings), Kate Anthony (Nurse Kate), T. J. Lowther (Intern Hank), Miguel Nájera (Janitor), T'Shawn Barett, Jr. (Jon), Shannon Lucio (Amanda), Zoe Boyle (Clara), Zack Shada (Andy), Adam Lazarre-White (Oncology Resident)

Though time has passed since George's death, everyone continues to struggle with his passing by finding distractions to keep themselves occupied. Meredith and Derek cope by consummating their marriage anywhere and everywhere, while Dr. Wyatt suggests that Cristina and Owen abstain from sex.



105 :06x03 - I Always Feel Like Somebody's Watchin' Me

First aired: Oct/01/2009
Writer: Tony Phelan, Joan Rater
Director: Michael Pressman
Guest star: Sarah Utterback (Nurse Olivia Harper), Adrienne Barbeau (Jodie Crawley), James Frain (Tom Crawley), Mark Saul (Intern Steve), Gloria Garayua (Intern Graciella), Amrapali Ambegaokar (Intern Dani), Tymberlee Chanel (Intern Claire), Molly Kidder (Intern Megan), Winston Story (Intern Leo), Candice Afia (Intern Laura), Joseph Williamson (Intern Pierce), Kim Swennen (Kelly), Joyce Lee (Julia), Taylor Geare (Sage), Curtis Harris (Tyler), Shi Ne Nielson (Paramedic #1), Nicole Cummins (Paramedic #2), Kerri Higuchi (Dr. Elizabeth Chen)

Izzie returns to work following her near-death experience. Meanwhile, the Seattle Grace residents brace for upcoming layoffs and try to position themselves in order to keep their jobs, with Cristina attempting to work with Arizona in pediatrics. Elsewhere, Bailey and Alex's complex case becomes increasingly difficult when the patient's schizophrenic son has issues with her care.



106 :06x04 - Tainted Obligation

First aired: Oct/08/2009
Writer: Jenna Bans
Director: Tom Verica
Guest star: Jeff Perry (Thatcher Grey), Ralph Waite (Irving Waller), Tom Amandes (Charlie Waller), Isabella Hofmann (Irene Waller), Jocko Sims (Randy), Kristen Ariza (Angela), Phil Abrams (Dr. Nelson), Payton Silver (Dr. Knox), Ursula Whittaker (Angry Attending #1), Mark Saul (Intern Steve)

Thatcher returns to the hospital in need of a new liver, and Meredith is the only one who is a match leaving her to make a tough decision. Meanwhile, Izzie finds common ground with a patient with tumors; and Mark, annoyed with Cristina, has her assist on an unusual surgery.



107 :06x05 - Invasion

First aired: Oct/15/2009
Writer: Mark Wilding
Director: Tony Phelan
Guest star: Alexie Gilmore (Sarah), Sarah Drew (Dr. April Kepner), David Bowe (Don), Robert Baker (Dr. Charles Percy), Jack Gwaltney (Frank Newsbaum), J. P. Pitoc (Billy Sheehan), Brandon Scott (Dr. Ryan Spalding), Kathleen Wilhoite (Leslie Goldman), Nora Zehetner (Dr. Reed Adamson), Bruce French (Father Kevin), Freda Foh Shen (Missy Grant), Hector Elizondo (Mr. Torres), Mark Saul (Intern Steve), Gloria Garayua (Intern Graciella), Chelsea Ricketts (Jeanie), Ray Ford (Ray the Paramedic), Frank Ertl (Michael Goldman), John O'Brien (Lab Tech), Jesse Williams (Dr. Jackson Avery)

Seattle Grace and Mercy West residents compete for surgeries as the two hospitals are merged. Meanwhile, Arizona stands by Callie when Callie's father brings in a priest in hopes of convincing her to stop dating women.



108 :06x06 - I Saw What I Saw

First aired: Oct/22/2009
Writer: William Harper
Director: Allison Liddi
Guest star: Robert Baker (Dr. Charles Percy), Sarah Drew (Dr. April Kepner), Bill Fagerbakke (Roy Mackinaw), Erinn Hayes (Cathy Becker), Mitch Pileggi (Larry Jennings), Nora Zehetner (Dr. Reed Adamson), Moe Irvin (Nurse Tyler Christian), Saundra McClain (Lawyer), Jakob Miller (Danny Becker), Andrew Miller (Danny Becker), Mark Daugherty (Evan), Ron Roggé (Fire Captain), Arlene Santana (Nurse), John Bradford (Danny's Dad), Jesse Williams (Dr. Jackson Avery)

When a burn victim unexpectedly dies during a chaotic time in the emergency room, the Chief, with the help of board member Jennings, interview each of the residents in order to find who was to blame in the incident, leading each of the doctors to defend their actions of the day to save their jobs.



109 :06x07 - Give Peace a Chance

First aired: Oct/29/2009
Writer: Peter Nowalk
Director: Chandra Wilson
Guest star: Nora Zehetner (Dr. Reed Adamson), Mark Saul (Intern Steve), Faran Tahir (Isaac), Jesse Williams (Dr. Jackson Avery)

When Isaac, the hospital lab tech discovers he has an inoperable tumor wrapped around his spine, he seeks Derek for help. Meanwhile, Richard's authority is challenged by Derek.



110 :06x08 - Invest In Love

First aired: Nov/05/2009
Writer: Stacy McKee
Director: Jessica Yu
Guest star: Nora Zehetner (Dr. Reed Adamson), Robert Baker (Dr. Charles Percy), Mitch Pileggi (Larry Jennings), Alanna Masterson (Hillary Boyd), Khamani Griffin (Wallace Anderson), Caroline Choi (Laura Young), Erica Gimpel (Bethany Anderson), Angelo Tiffe (Trey Boyd), Derek Webster (Paul Anderson), Nealla Gordon (Jill Boyd), Jesse Williams (Dr. Jackson Avery)

The parents of Arizona's young patient offer the hospital a sizeable donation, but when the patient takes a turn for the worse, Arizona finds herself torn between the hospital and the patient. Meanwhile, Cristina tests her boundaries with Owen.



111 :06x09 - New History

First aired: Nov/12/2009
Writer: Allan Heinberg
Director: Rob Corn
Guest star: Kim Raver (Dr. Teddy Altman), Joel Grey (Dr. Singer), Loretta Devine (Adele Webber), Robert Baker (Dr. Charles Percy), Nora Zehetner (Dr. Reed Adamson), Steven W. Bailey (Joe), James DuMont (Sheldon Morris), Heather Corwin (Casey's Mom), Mason Cook (Casey), Jesse Williams (Dr. Jackson Avery)

Owen recruits a new cardiothoracic surgeon, Iraqi War vet Dr. Teddy Altman, but Cristina is quick to judge her abilities in the O.R. Meanwhile, Izzie returns to Seattle Grace with her former high school teacher who is suffering from dementia; and the Chief begins to feel the strain of his new responsibilities post-merger.



112 :06x10 - Holidaze

First aired: Nov/19/2009
Writer: Krista Vernoff
Director: Robert Berlinger
Guest star: Kim Raver (Dr. Teddy Altman), Jeff Perry (Thatcher Grey), Steven W. Bailey (Joe), Frankie Faison (William Bailey), Leven Rambin (Sloan Riley), Danielle Panabaker (Chelsea), James Nardini (Anguished Father), Nathan West (Mike), Hillary Tuck (Mrs. Jacobsen), Jesse Williams (Dr. Jackson Avery)

As the holidays come and go, Miranda has a surprise visit from her father, William, who has a strong disapproval of her choices in life. Mark and Lexie must cope with a person who re-enters Mark's life, and Thatcher Grey questions the Chief's behavior, but Meredith is quick to come to the Chief's defense.



113 :06x11 - Blink

First aired: Jan/14/2010
Writer: Debora Cahn
Director: Randall Zisk
Guest star: Kate Walsh (Addison Montgomery), Kim Raver (Dr. Teddy Altman), Cynthia Stevenson (Ruthie Carlin), Robert Baker (Dr. Charles Percy), Nora Zehetner (Dr. Reed Adamson), Leven Rambin (Sloan Riley), Sinqua Walls (Tom Kates), Stephon Fuller (Gregor), James DuMont (Sheldon Morris), Giselle Jones (Jessie Kates), Amol Shah (Rob Stanton), Jarrod Crawford (Dr. Oslow), Kerri Higuchi (Dr. Elizabeth Chen), Mark Saul (Intern Steve)

Mark flies Addison to Seattle so that she can help perform a difficult procedure on his pregnant daughter. Meanwhile, Owen begins to question Teddy's motives when she has Cristina be the lead on a complex surgery; and Derek becomes suspicious when the Chief has Meredith assist on a high-profile operation.



114 :06x12 - I Like You So Much Better When You're Naked

First aired: Jan/21/2010
Writer: Joan Rater, Tony Phelan
Director: Donna Deitch
Guest star: Kim Raver (Dr. Teddy Altman), Mitch Pileggi (Larry Jennings), Jesse Williams (Dr. Jackson Avery), Dan Bucatinsky (Jeff), Paul Vogt (Aaron Framici), Moe Irvin (Nurse Tyler Christian)

Derek confronts Richard over his alcoholism in an attempt to help his friend and the hospital. Izzie returns to reconcile with Alex, and tensions between Teddy, Cristina and Owen escalate.



115 :06x13 - State of Love and Trust

First aired: Feb/04/2010
Writer: Stacy McKee
Director: Jeannot Szwarc
Guest star: Kim Raver (Dr. Teddy Altman), Mitch Pileggi (Larry Jennings), Robert Baker (Dr. Charles Percy), Sarah Drew (Dr. April Kepner), Nora Zehetner (Dr. Reed Adamson), Jason Winston George (Ben), Spencer Garrett (Jim), Chastity Dotson (Leslie), Jesse Williams (Dr. Jackson Avery), Cody Christian (Brad), Molly Kidder (Intern Megan)

After being named interim chief, Derek begins to settle into his new position but faces a lawsuit when Bailey and Meredith's patient wakes up during surgery. Meanwhile, Teddy refuses to let Cristina be a part of her service, Alex continues to work with Arizona in pediatrics, and Mark avoids talking to Lexie who is still heartbroken over their break up.



116 :06x14 - Valentine's Day Massacre

First aired: Feb/11/2010
Writer: William Harper
Director: Stephen Cragg
Guest star: Kim Raver (Dr. Teddy Altman), Pamela Reed (Mrs. Banks), Sarah Drew (Dr. April Kepner), Jesse Williams (Dr. Jackson Avery), Jason Winston George (Ben), Leven Rambin (Sloan Riley), Brian George (Emile), Kelvin Brown (Frankie)

The doctors treat dozens of people when the roof of a romantic restaurant collapses on Valentine's Day, Meredith struggles with her new duties as the chief's wife.



117 :06x15 - The Time Warp

First aired: Feb/18/2010
Writer: Zoanne Clack
Director: Rob Corn
Guest star: Missi Pyle (Dr. Nicole Baylow), Jason Winston George (Ben), Gregg Henry (Dr. Gracie), Sarah Paulson (Young Ellis Grey), Jesse Williams (Dr. Jackson Avery), Ravi Kapoor (Sunder Atluri), J. August Richards (Young Richard Webber), Rachel Nicks (Alicia Tatum), Steven W. Bailey (Joe), Ian Jensen (Phillip Nichols)

Callie, Bailey and Richard present pivotal surgical cases from their pasts when Derek restores the hospital lecture series.



118 :06x16 - Perfect Little Accident

First aired: Mar/04/2010
Writer: Peter Nowalk
Director: Bill D'Elia
Guest star: Kim Raver (Dr. Teddy Altman), Tess Harper (Mrs. Nelson), Chelcie Ross (Dr. Harper Avery), Robert Baker (Dr. Charles Percy), Jesse Williams (Dr. Jackson Avery), Blake Bashoff (Elliott Meyer), Annie Fitzgerald (Kathy Nelson), Courtney Ford (Jill Meyer)

When famous surgeon Dr. Harper Avery is rushed to Seattle Grace-Mercy West, the staff is surprised to discover that one of their own is related to this legend, and his unorthodox request for his surgery causes tensions t between Derek and Richard. Meanwhile Callie and Arizona try to help Teddy and Sloan move on from their pasts and find greener pastures.



119 :06x17 - Push

First aired: Mar/11/2010
Writer: Debora Cahn
Director: Chandra Wilson
Guest star: Kim Raver (Dr. Teddy Altman), Diane Venora (Audrey Taylor), Dennis Boutsikaris (Don Taylor), Jason Winston George (Ben), Jesse Williams (Dr. Jackson Avery), Geoffrey Blake (Jim), Moon Unit Zappa (Kelly), Roshawn Franklin (Todd Holmes), Elizabeth Ho (Molly)

A patient who needs an extremely difficult surgery comes to Seattle Grace, and it's Richard and Owen who vie for the opportunity to tackle it. But the decision lies in the hands of Derek, who deems that Owen should take on the surgery, leaving Richard bitter. Meanwhile, Bailey deals with her own personal struggles when she nervously prepares for another date with Ben.



120 :06x18 - Suicide is Painless

First aired: Mar/25/2010
Writer: Joan Rater, Tony Phelan
Director: Jeannot Szwarc
Guest star: Kim Raver (Dr. Teddy Altman), Richard T. Jones (Captain Dan), Sara Gilbert (Kim Allen), Robert Baker (Dr. Charles Percy), Sarah Drew (Dr. April Kepner), Jesse Williams (Dr. Jackson Avery), Derek Cecil (Sean Allen), Lance Barber (Phil), Zachary Knower (Nick Kelsey), Adam Kulbersh (Tommy)

When Teddy's patient seeks to end treatment and her life, she turns to Hunt for help. The situation triggers Hunt's memories of his life at war and his past relationship with Teddy. Meanwhile, Callie and Arizona have a difference in opinion on what their future holds, and Richard tries to adjust to his role as a surgeon.



121 :06x19 - Sympathy for the Parents

First aired: Apr/01/2010
Writer: Allan Heinberg
Director: Debbie Allen
Guest star: Robert Baker (Dr. Charles Percy), Jesse Williams (Dr. Jackson Avery), Michael O'Neill (Gary Clark), Sarah Drew (Dr. April Kepner), Wendy Raquel Robinson (Gina Thompson), Leven Rambin (Sloan Riley), Jake McLaughlin (Aaron Karev), David Ramsey (Jimmy Thompson)

When Alex's brother shows up at the hospital with a hernia, Alex must get Bailey's approval for pro-bono surgery; parts of Alex's past are revealed to his friends and colleagues.



122 :06x20 - Hook, Line and Sinner

First aired: Apr/29/2010
Writer: Meg Marinis
Director: Tony Phelan
Guest star: Scott Cohen (Dr. Tom Evans), Glenn Morshower (Walter), Jesse Williams (Dr. Jackson Avery), Sarah Drew (Dr. April Kepner), Leven Rambin (Sloan Riley), Nicholas Purcell (Doug)

Sloan returns to Mark's apartment, just as she's going into labor, and Teddy, Mark and the still-fighting Callie and Arizona are there to help with the birth and to get Mark through his grandson's pending adoption. Meanwhile Teddy sees Derek's invitation to illustrious cardiothoracic surgeon Tom Evans' as a threat to her future employment at the hospital, and the team work on a crab boat captain who has been stabbed with a giant shark hook



123 :06x21 - How Insensitive

First aired: May/06/2010
Writer: William Harper
Director: Tom Verica
Guest star: Michael O'Neill (Gary Clark), Jesse Williams (Dr. Jackson Avery), Robert Baker (Dr. Charles Percy), Nora Zehetner (Dr. Reed Adamson), Sarah Drew (Dr. April Kepner), Jerry Kernion (Bobby Corso), Rosalie Ward (Mrs. Corso), Abigail McFarlane (Jamie Anders), Mia Barron (Lauren Turner), Alyssa Shafer (Kelly Temple)

Bailey preps the team with mandatory sensitivity training prior to admitting a 700-pound patient with compounded medical issues, and the case proves to be challenging in every sense of the word. Meanwhile Derek has to come face to face with a former patient's husband in a wrongful death deposition, and spending time with a heart patient's daughter opens up some old wounds for Cristina,




124 :06x22 - Shiny Happy People

First aired: May/13/2010
Writer: Zoanne Clack, Peter Nowalk
Director: Edward Ornelas
Guest star: Jesse Williams (Dr. Jackson Avery), Nora Zehetner (Dr. Reed Adamson), Jason Winston George (Ben), Demi Lovato (Hayley), Marion Ross (Betty), Alan Mandell (Henry), Amy Farrington (Mary), Jonathan Goldstein (Ken), Austin Highsmith (Amber), Emily Bergl (Trisha)

An elderly patient admitted into the E.R. for a heart condition sees a familiar face, a long lost love who happens to be in the E.R. as well for a fractured arm, and the staff find themselves caught up in their love story. Meanwhile, Karev treats a troubled teenage patient whose parents brought her in for schizophrenia, and Meredith can't help but tell Cristina about her suspicions of Owen



125 :06x23 - Sanctuary

First aired: May/20/2010
Writer: Shonda Rhimes
Director: Stephen Cragg
Guest star: Sarah Drew (Dr. April Kepner), Robert Baker (Dr. Charles Percy), Tom Irwin (Officer Hancock), Michael O'Neill (Gary Clark), Ryan Devlin (Bill), Mandy Moore (Mary), Jesse Williams (Dr. Jackson Avery), Nora Zehetner (Dr. Reed Adamson), China Anderson (Ruby), Jason Graham (Ken), Angelina Hong (Sobbing Woman), Arlene Santana (Nurse), Kelsey Scott (Karen), Adam Shapiro (Pete), Moe Irvin (Nurse Tyler Christian)

The hospital is hit with an unprecedented crisis; Meredith and Cristina's surgical skills are put to the test.



126 :06x24 - Death and All His Friends

First aired: May/20/2010
Writer: Shonda Rhimes
Director: Rob Corn
Guest star: China Anderson (Ruby), Ryan Devlin (Bill), Jason Graham (Ken), Mandy Moore (Mary), Kelsey Scott (Karen), Adam Shapiro (Pete), Michael O'Neill (Gary Clark), Tom Irwin (Officer Hancock), Robert Baker (Dr. Charles Percy), Sarah Drew (Dr. April Kepner), Jesse Williams (Dr. Jackson Avery)



127 :07x01 - With You I'm Born Again

First aired: Sep/23/2010
Writer: Krista Vernoff
Director: Rob Corn
Guest star: James Tupper (Andrew Perkins), Jason Winston George (Dr. Ben Warren), Debra Mooney (Mrs. Hunt), Judy Prescott (Donna Bevell), Matthew Fahey (Greg Bevell), Angela Elayne Gibbs (Mrs. Rollins (as Angela E. Gibbs)), Dale Waddington Horowitz (OB Resident), Annie O'Donnell (Older Woman), Paul Zies (Biker Dude), Toussaint Waterman (Cop), Cliff Berens (Patient), Joel Kindrick (Judge)

The hospital staff is trying to deal with physical and emotional trauma in the wake of the deadly rampage of a vengeful gunman. As Dr. Perkins, a trauma counselor, is brought in to help in the recovery and to assess each doctor’s readiness to return to work, Derek makes a spontaneous decision to resign as Chief and rushes back into surgery, taking everything a little too fast, and Cristina buries herself in her wedding planning.



128 :07x02 - Shock to the System

First aired: Sep/30/2010
Writer: William Harper
Director: Tom Verica
Guest star: James Tupper (Andrew Perkins), Ashley Crow (Linda Cotler), John Walcutt (Paul Cotler), Camille Chen (Kerry Schultz), Walter Perez (Russ), Chuck Hittinger (Mitch), Eric James Ramey (Warren Griffith)

After weeks of concealing the fact she was pregnant and miscarried, Meredith at last tells Derek and is finally cleared to return to her surgical duties in the wake of the hospital shooting spree; Cristina experiences post-traumatic stress disorder in the midst of an operation; and Bailey refuses to let Alex operate until he agrees to have the bullet in his chest removed.



129 :07x03 - Superfreak

First aired: Oct/07/2010
Writer: Mark Wilding
Director: Michael Pressman
Guest star: Caterina Scorsone (Dr. Amelia Shepherd), James Tupper (Andrew Perkins), Dana Davis (Gretchen), Art Chudabala (Jerry Adams), Omar Gooding (Danny), Jolene Kim (Tess Adams), Arlene Santana (Nurse), Sean Carrigan (Todd)

When Derek receives an unexpected and unwelcome visit from his estranged sister, Amelia, issues between the siblings -- both past and present -- come to the surface; the Chief tries to help Alex when he notices that he's refusing to use the elevators after his near-fatal shooting; and Meredith and Derek continue their efforts to ease Cristina back into surgery after her post-traumatic stress



130 :07x04 - Can’t Fight Biology

First aired: Oct/14/2010
Writer: Peter Nowalk
Director: Edward Ornelas
Guest star: Jon Curry (Fred Fisher), Nathan Halliday (Jake Fisher), Frances Conroy (Eleanor), Diane Farr (Lila), Kate Martin (Vickie Fisher), Christian Clemenson (Ivan Fink), Stacey Miller (Kimmy), Jackie Houston (Realtor), Jennifer Say Gan (Dr. Keating), Linda Klein (Nurse Linda)

Things are hostile on all fronts when a visit to the obstetrician results in some disturbing news for Meredith and Derek, and Lexie loses it when she notices Meredith and April getting closer. Meanwhile a car crash brings in multiple traumas and Jackson tries using his physical attributes to get ahead in the operating room, while Cristina's self-doubt carries outside of the hospital and into her house hunting with Owen



131 :07x05 - Almost Grown

First aired: Oct/21/2010
Writer: Brian Tanen
Director: Chandra Wilson
Guest star: Ron Perkins (Roy), Candice Patton (Meg), Randee Heller (Joanne), Deborah Strang (Ellie), Charlie Koznick (Trey), Susan Slome (Mindy), Jarrod Bailey (Seth)

As part of their training, the Chief puts Seattle Grace's residents, including Meredith, Cristina, April and Jackson, in charge; meanwhile, Derek, Callie, Owen and the other attending surgeons compete for a million-dollar grant



132 :07x06 - These Arms of Mine

First aired: Oct/28/2010
Writer: Stacy McKee
Director: Stephen Cragg
Guest star: Mandy Moore (Mary), Ryan Devlin (Bill), Paola Andino (Lily), Vanessa Martinez (Gretchen), Audrey Wasilewski (Nicole), Amanda Foreman (Nora), John Lacy (Zack), Linda Klein (Nurse Linda), Crystal Kwon (Nurse)

A documentary film crew visits the hospital six months after the shooting to document the road to recovery for doctors and patients. The camera lenses follow Derek, Owen, Mark & Callie as they ambitiously perform a rare arm transplant surgery, Meredith helps Cristina put on a brave face for the cameras, and Bailey's patient, Mary, returns for her surgery -- which marks the first time they've all seen of each other since that fateful day



133 :07x07 - That's Me Trying

First aired: Nov/04/2010
Writer: Austin Guzman
Director: Tony Phelan
Guest star: Amber Benson (Corrine), Ron Perkins (Roy), Mandy Moore (Mary), Ryan Devlin (Bill), Melinda Page Hamilton (Dr. Jennifer Stanley), Wynn Everett (Christy), Linda Klein (Nurse Linda), Leith M. Burke (Dr. McQueen), Mark Saul (Resident Steve), Alixandree Antoine (CCU Nurse), Arlene Santana (Nurse)

The residents are pushed to their limits when Owen puts them through a rigorous trauma certification drill; meanwhile, Cristina is also tested when left alone to monitor a very ill lung transplant patient



134 :07x08 - Something's Gotta Give

First aired: Nov/11/2010
Writer: William Harper
Director: Jeannot Szwarc
Guest star: Peter MacNicol (Dr. Phil Stark), Allan Louis (Ronald Lace), Omid Abtahi (Aasif), Bridget Sienna (Mrs. Cortez), Philip Shahbaz (Arab Translator), Bob Rumnock (ND Doctor), Terrell Lee (Diplomatic Security Guard), Dalila Ali Rajah (Leanne), Michael Medico (Martin), Anthony Batarse (Emir's Aide 1), Ammar Daraiseh (Aide), Mike Kersey (Sales Clerk), Maz Siam (Emir's Chief of Staff), Sabin Rich (Hairstylist), Teresa Huang (VIP Nurse), Rachel Andersen (Peds Nurse), Michael Brouillet (Secret Service Agent), Miles Elliot (Boy)

Top security measures go into place as a team of doctors, led by the Chief, try to save the life of a major policitcal figure from the Middle East. Meanwhile Cristina decides to finally decorate her new place and throw a housewarming party, and Alex shows up late from a weekend getaway to his first day of rounds with the new Pediatrics Attending, Dr. Phil Stark.



135 :07x09 - Slow Night, So Long

First aired: Nov/18/2010
Writer: Zoanne Clack
Director: Rob Bailey
Guest star: Peter MacNicol (Dr. Phil Stark), Steven W. Bailey (Joe), Kimberly Guerrero (Mrs. McNeil), Bubba Lewis (Kendrick Nystrom), Cathryn de Prume (Mrs. Nash), Jeff Cole (Mr. Nash (as Jeffrey Cole)), John Hemphill (Brad Nystrom), Christina Scherer (Lauren), Stephen Gabriel (Lucas), Masam Holden (Reilly Nash), Nicole Cummins (Paramedic Nicole), Justin Alston (CT Tech), Payton Silver (Dr. Knox), Alixandree Antoine (O.R. Nurse), Linda Eve Miller (ER Nurse), Alex Quijano (Random Guy), Charles Carpenter (Party Guy #1), Fabrizio Zacharee Guido (Drew McNeil)

Derek lands the grant he needs for his clinical trial and all the attendings take him out to Joe's Bar to celebrate, but they get a surprise when they see someone they know already at the bar. Meanwhile, Meredith and Alex have to fend for themselves during the night shift with a nine-year-old patient who's experiencing post-surgical complications and his very pushy mother.



136 :07x10 - Adrift and at Peace

First aired: Dec/02/2010
Writer: Joan Rater, Tony Phelan
Director: Allison Liddi
Guest star: Scott Foley (Henry Burton), Daniel Sunjata (Nurse Eli), Jamie Chung (Trina Paiz), Lenora May (Sheila), Ken Meseroll (Ron), Sarah Hunley (Adriana Kay), Barry Livingston (Wayne Sheehan), Nicole Cummins (Paramedic #2), Michael Lesly (Paramedic #1), Payton Silver (Dr. Knox), Carissa Kosta (O.R. Nurse), Kris A. Jeffrey (Fisherman #2 (as Kris Jeffrey)), Joel Bond (Marina Worker), Ray Singh (ER Nurse), Michael Brady (Fisherman #1)

Despite Meredith's objections to the idea, a concerned Derek takes Cristina on a fishing trip in order to get away from it all, while Teddy, feeling directionless without Cristina, directs all of her efforts and compassion towards a dying patient who lacks the proper insurance to seek medical treatment.



137 :07x11 - Disarm

First aired: Jan/06/2011
Writer: Krista Vernoff
Director: Debbie Allen
Guest star: Scott Foley (Henry Burton), Peter MacNicol (Dr. Phil Stark), Tom Irwin (Officer Hancock), Paula Newsome (Mrs. Sturgeon), Susan Ruttan (Mrs. Swore), Jonathan Dane (Michael Fazioli), Tony Casale (Dave the surgeon), Brooke Blanchard (Jill the Paramedic), Ray Ford (Ray the Paramedic), Brett Glazer (Paramedic Brett), Grace Rowe (Paramedic Grace), Benjamin Scott Perry (Chuck Fowler), Melvin Abston (Cop), Teresa Huang (Nurse), Joyce Brew (Scrub Nurse), Darren Dupree Washington (Reporter), Darryl Sivad (Justice of the Peace), Natalie Smyka (Student), Brian Ames (Passerby)

News of the incoming mass causalities after a gunman opens fire at a local college hits the staff hard when they must spring into action, even while their own wounds are still fresh; and Arizona does not receive a warm welcome home at the hospital.



138 :07x12 - Start Me Up

First aired: Jan/13/2011
Writer: Natalie Krinsky
Director: Mark Jackson
Guest star: Scott Foley (Henry Burton), Adam Busch (Fred Wilson), Kevin Christy (Brady), Wilson Cruz (Kyle), Amanda Leighton (Sarah Cassidy), Amy Rosoff (Kira Donnelly), Tommy Snider (Edward Taylor), Amber Stevens (Laurel Henson), Daniel Sunjata (Nurse Eli), Mark Charran (Hudson Powell), Mark Fite (Jared Cassidy), Tracy Maddox (Sophia Cassidy), Grace Rowe (Paramedic Grace)

Arizona seeks Mark's advice as she tries to reconcile with Callie, who has big news of her own; Teddy must make a key decision for Henry during his surgery; and on the same day the residents receive a new crop of interns, the Chief announces he is looking for a new Chief Resident.



139 :07x13 - Don't Deceive Me (Please Don't Go)

First aired: Feb/03/2011
Writer: Mark Wilding
Director: Kevin McKidd
Guest star: Rachael Taylor (Dr. Lucy Fields), Harrison Page (Daniel Cobb), L. Scott Caldwell (Allison Cobb), Angela Paton (Martha), Frank Kopyc (John Driscoll), Evans Brown (Orderly), Hugh Holub (Ben), Payton Silver (Dr. Knox), Carolyn Power (Victoria)

Derek begins a clinical trial for an Alzheimer's therapy. Friction arises when he chooses to exclude Meredith from assisting with this research. Bailey uses Twitter to describe an abdominal surgery, provoking the Chief's ire - until the feed creates a degree of collaboration that spares a patient from a lifetime of serious diabetes following a pancreatectomy. Callie's concern over her perfectly normal pregancy symptoms drive new obstetrician Lucy Fields, Mark and Arizona to distraction.



140 :07x14 - P.Y.T. (Pretty Young Thing)

First aired: Feb/10/2011
Writer: Austin Guzman
Director: Steve Robin
Guest star: Jeff Perry (Thatcher Grey), Rachael Taylor (Dr. Lucy Fields), Alexa Havins (Danielle), Tracey Aileen Leigh (Sarah Cooke (as Tracey A. Leigh)), DeSean Terry (Colin Cooke), Shelli Boone (Paula Glass), Patricia Forte (Mrs. Glass), Michael Esparza (Marcus), Noah Schuffman (Randy), John O'Brien (Lab Tech), Ken Takemoto (Trial Patient #1), Karen Tarleton (Trial Patient #2), Darius Dudley (Trial Patient #3), Roberta Bassin (Trial Patient #4), Duane R. Shepard, Sr. (Trial Patient #5 (as Duane Shepard Sr.)), Catherine Grace (Trial Patient #6), Cici Lau (Trial Partner #1), Aixa Clemente (Trial Partner #2), Steven Anders (Trial Partner #3), Edythe Davis (Trial Partner #4)

Thatcher Grey, Meredith and Lexie's father, returns to Seattle Grace with stomach pains and a new, twenty-something tattooed girlfriend, Danielle. Meanwhile, Alex clashes with the new OB, Dr. Lucy Fields, over a patient and Mark places Jackson on his service in exchange for information on Lexie.



141 :07x15 - Golden Hour

First aired: Feb/17/2011
Writer: Stacy McKee
Director: Rob Corn
Guest star: Scott Foley (Henry), Rachael Taylor (Dr. Lucy Fields), Daniel Sunjata (Eli), Loretta Devine (Adele), Moe Irvin (Nurse Tyler), Jeffrey Doornbos (Mitch), Elizabeth Bogush (Gia), Dondre T. Whitfield (Oliver), Jason Gray-Stanford (Josh), Jacy King (Whitney), Cade Owens (Nathan), John Henry Canavan (Stewart), Nick Armstrong (Dave), Josh Randall (William), Billy Wood (code nurse), Payton Silver (Dr. Knox), Ariel Felix (C.T. booth tech), Linda Klein (Scrub Nurse Linda)

Meredith, looking to prove she is Chief Resident material, learns that anything and everything can happen in an hour's time when she steps up to run the ER for a night; meanwhile, Bailey sneaks off with Eli and gets into a little mischief, and everyone is surprised when the Chief's wife, Adele, shows up as one of the ER patients.C



142 :07x16 - Not Responsible

First aired: Feb/24/2011
Writer: Debora Cahn
Director: Debbie Allen
Guest star: Peter MacNicol (Dr. Phil Stark), Nancy Travis (TBA)

Meredith must choose between her fertility treatments and her eyesight when she begins having trouble seeing, Mark makes it clear to Callie and Arizona that he takes his role as father-to-be very seriously, and April discovers there's more to Dr. Stark than first appears.



143 :07x17 - This Is How We Do It

First aired: Mar/24/2011
Writer: Peter Nowalk
Director: Edward Ornelas
Guest star: Scott Foley (Henry), Rachael Taylor (Dr. Lucy Fields), Peter MacNicol (Dr. Stark), Loretta Devine (Adele), Daniel Sunjata (Eli), Marina Sirtis (Sonya), Pej Vahdat (Tarik), Colleen McDermott (Clara), Rick Peters (Sean), Denice J. Sealy (E.R. Nurse), Gordon James (Desk Nurse), Payton Silver (Dr. Knox)

Richard is desperate for Derek and Meredith to accept Adele into their Alzheimer's trial, but will Adele stand in her own way? Meanwhile Mark and Arizona have conflicting ideas of the kind of baby shower Callie wants, Teddy is freaked out when Henry has another health complication -- leaving them both a little exposed -- and the competitiveness amongst the residents for the Chief Resident position is amplified when Richard receives the green light for his diabetes clinical trial.



144 :07x18 - Song Beneath the Song

First aired: Mar/31/2011
Guest star: Kate Walsh (Addison Montgomery), Scott Foley (Henry Burton), Rachael Taylor (Dr. Lucy Fields), Daniel Sunjata (Nurse Eli)

Callie and Arizona are rushed back to Seattle Grace Mercy West Hospital after a car accident, where Callie is in critical condition. The doctors must act quickly to save both Callie and her unborn baby, while tensions between Mark and Arizona rise. The episode is done as a musical, using various top-40 hits, with the words being sung by the characters.



145 :07x19 - It’s A Long Way Back

First aired: Apr/28/2011
Writer: William Harper
Director: Steve Robin
Guest star: Scott Foley (Henry), Peter MacNicol (Dr. Stark), Loretta Devine (Adele), Doris Roberts (Gladys), James Tupper (Andrew Perkins), Newell Alexander (Ed Beckert), Maurice Whitfield (Cop), T'Shawn Barett, Jr. (Jon), Anne Leyden (Pharmicist), Linda Klein (Scrub Nurse Linda)

Everyone pulls together to help Callie and baby Sofia on their painstaking journeys to recovery in hopes of allowing mother and baby to finally meet; the sudden death of a clinical trial patient has Derek proceeding with more caution while Meredith makes a calculated and risky move; Alex treats a cranky old rich woman dying of cancer and gets an idea for a grandiose endeavor that is sure to get him the Chief Resident spot; and Teddy is pleasantly surprised by the return of a familiar face.



146 :07x20 - White Wedding

First aired: May/05/2011
Writer: Stacy McKee
Director: Chandra Wilson
Guest star: Peter MacNicol (Dr. Stark), James Tupper (Andrew Perkins), Denis Arndt (Colonel Robbins), Hector Elizondo (Carlos Torres), Gina Gallego (Lucia Torres), Judith Ivey (Barbara Robbins)

As Callie and Arizona's wedding approaches, the couple quickly realize that the day they've been looking forward to is not turning out the way they'd envisioned. Meanwhile Alex continues to make the other residents jealous as he appears to be the top contender for Chief Resident, Meredith and Derek make a decision that will change their lives forever, and Dr. Perkins presents Teddy with a very tempting proposition.



147 :07x21 - I Will Survive

First aired: May/12/2011
Writer: Zoanne Clack
Director: Tom Verica
Guest star: Scott Foley (Henry), Rachael Taylor (Dr. Lucy Fields), James Tupper (Andrew Perkins), Ochuwa Oghie (Lebo), Anehita Okojie (Abena), Wilmer Calderon (Raul), Toni Torres (Annette), Anthony Keyvan (Miguel), Denice J. Sealy (Bronchosco Py Nurse), Janora McDuffie (social worker), Linda Klein (Scrub Nurse Linda)

Personal and work pressures are adding up and have Meredith visibly on edge, Owen conducts formal interviews for the Chief Resident position, Cristina grows increasingly defiant, Alex and Lucy's undefined relationship gets tested, and Jackson suddenly backs out of the Webber's diabetes trial.



148 :07x22 - Unaccompanied Minor

First aired: May/19/2011
Writer: Debora Cahn
Director: Rob Corn
Guest star: Scott Foley (Henry), Rachael Taylor (Dr. Lucy Fields), James Tupper (Andrew Perkins), Daniel Sunjata (Eli), Beverly Todd (Gilda Bix)

News of Meredith's dishonesty in the clinical trial comes to light, leading to unanticipated consequences for both her and others. Cristina finds herself in a compromising situation, which forces her to decide between her career and her relationship. Meanwhile, Owen posts his decision for chief resident and Teddy makes a surprising choice regarding her love life -- and her future.



149 :08x01 - Free Falling

First aired: Sep/22/2011
Writer: Tony Phelan, Joan Rater
Director: Rob Corn
Guest star: MacKenzie Astin (Danny), Amy Price Francis (Susannah), Robin Weigert (Karen)

The fifth-year residents return for the first day of a year that will make or break their careers: Meredith faces the consequences of tampering with Derek's clinical trial and is terminated at the hospital; April tries to step up to the plate as Chief Resident in the wake of a giant sinkhole in the middle of Seattle; and Cristina and Owen are still at odds over their drastically different feelings for their unborn child.



150 :08x02 - She's Gone

First aired: Sep/22/2011
Writer: Debora Cahn
Director: Rob Corn
Guest star: MacKenzie Astin (Danny), Amy Price Francis (Susannah), Scott Foley (Henry), Mitch Pileggi (Larry Jennings)

News of Meredith and Derek's unsteady relationship raises a red flag for Zola's adoption counselor; Alex quickly realizes that he has become the outcast of the group after ratting out Meredith; and Cristina makes a tough decision regarding her unexpected pregnancy. Also, Chief Webber brings Henry in for a last minute surgery, alarming Teddy.



151 :08x03 - Take the Lead

First aired: Sep/29/2011
Writer: William Harper
Director: Chandra Wilson

The Chief makes a career-changing decision that shocks Seattle Grace Hospital; Cristina and Owen try to find normalcy in their relationship; April continues to struggle in her new role; and the 5th year residents are given their first solo surgeries, only to find out that even the most routine procedures aren't always easy.



152 :08x04 - What Is It About Men

First aired: Oct/06/2011
Writer: Stacy McKee
Director: Tom Verica
Guest star: Daniel Sunjata (Eli), Jason Winston George (Ben), Jeremy Howard (Keith), Todd Buonopane (Greg), Matt Doherty (Carter)

The doctors of Seattle Grace are called upon to man up when a stampede at a comic book convention causes an influx of colorful characters in the ER - blurring the lines of fantasy and reality; Mark shows his softer side with baby Sofia when Arizona and Callie go out of town, but at work he continues to give Jackson a hard time; Ben returns to the ER, only to find that Nurse Eli has moved in on Bailey; and the male doctors bond over their frustrations with women.



153 :08x05 - Love, Loss and Legacy

First aired: Oct/13/2011
Writer: Denise Hahn
Director: Stephen Cragg
Guest star: Daniel Sunjata (Eli), Jason Winston George (Ben), Debbie Allen (Catherine Avery), Mason McCulley (Ryan), Robert Hoffman (Chad)

The residents try their hardest to impress surgical great Catherine Avery (who also happens to be Jackson's mother) when she arrives at Seattle Grace to perform a groundbreaking transplant surgery; Arizona and Alex find their hands tied with a confidentiality issue when a familiar patient comes into the ER; meanwhile, a love-struck Teddy throws a dinner party for the couples, and Bailey makes a decision regarding her love life.



154 :08x06 - Poker Face

First aired: Oct/20/2011
Writer: Peter Nowalk
Director: Kevin McKidd
Guest star: Lee Majors (Chuck Cain)

After being blackballed by most of the surgeons, Meredith uses Lexie to spark Derek's interest in her patient's rare brain tumor case and, in secret, gives guidance to April with Bailey's clinical trial; Callie's wish for Arizona and Mark to form a friendship comes to fruition and she realizes it's more irritating than helpful; Alex and Teddy research alternative surgeries for a very superficial patient; and Callie and Cristina struggle with a very difficult spinal surgery.



155 :08x07 - Put Me In, Coach

First aired: Oct/27/2011
Writer: Jeannine Renshaw
Director: Debbie Allen
Guest star: Scott Foley (Henry Burton)

Owen stresses teamwork and moves his leadership role over to the baseball field when he signs the doctors up for a baseball league, pitting them against their biggest competition, Seattle Presbyterian; Lexie tries to hide her jealous rage when she sees Mark with a new woman, but her emotions get the better of her; Alex fights to keep Zola at Seattle Grace after it is suggested that she be moved to another hospital due to a conflict of interest with Meredith and Derek; and Richard scolds Meredith and Bailey for their feud.



156 :08x08 - Heart-shaped Box

First aired: Nov/03/2011
Writer: Austin Guzman
Director: Jessica Yu
Guest star: Debra Monk (Louise O'Malley), Scott Foley (Henry Burton)

The doctors become nostalgic when George O'Malley's mother, Louise, returns to Seattle Grace for medical help after a botched surgery at a neighboring hospital; the residents are inspired by a medical miracle when they witness a harvested heart that continues to beat outside the body; a new pediatric fellow excites Arizona and makes Alex feel threatened; Jackson lets his suspicions about Mark and Lexie interfere with his work; and Henry and Teddy have their first marital fight when he expresses interest in pursuing medical school.



157 :08x09 - Dark Was the Night

First aired: Nov/10/2011
Writer: Debora Cahn
Director: Allison Liddi

Teddy puts her husband’s life in the hands of her peers when Henry is sent to the OR for surgery and she’s called away on another case; Meredith and Derek receive the long-awaited news about Zola; Callie and Jackson come under fire when their patient experiences post-surgery complications; and Meredith and Alex are involved in a life-threatening situation when they travel to a neighboring hospital to tend to a sick newborn.



158 :08x10 - Suddenly

First aired: Jan/05/2012
Writer: Stacy McKee
Director: Ron Underwood
Guest star: Scott Foley (Henry Burton), Jason Winston George (Ben), Dylan Bruno (Griffin), Holley Fein (Julia), Stella Maeve (Lily)

A severe car crash involving an entire family results in an all-hands-on situation in the ER, as the eldest daughter is left to make the toughest decision of her life. Meanwhile Teddy, still in the dark about Henry's death, calls upon Cristina to help with her patient in the O.R., and Lexie finds herself working alongside Mark's new girlfriend, Julia, during an eye surgery.



159 :08x11 - This Magic Moment

First aired: Jan/12/2012
Writer: Zoanne Clack
Director: Steve Robin

The doctors split into teams for a risky surgery involving conjoined twins; Bailey recruits Meredith to be a buffer between her and Ben when he puts pressure on moving their relationship to a more serious level; Richard teaches Alex a tough lesson in the OR; meanwhile Teddy questions Cristina about what exactly happened to Henry during his surgery.



160 :08x12 - Hope For The Hopeless

First aired: Jan/19/2012
Writer: Peter Nowalk
Director: Mark Jackson
Guest star: Loretta Devine (Adele Webber)

Richard performs his 10,000th surgery on a pair of bickering sisters who come into the hospital for a liver transplant; Derek and Lexie take on a neuroblastoma case that has been previously deemed inoperable; Teddy and Cristina cross the line when they go against Owen's orders and try to steal a case from Alex and Dr. McQueen; Ellis Grey's shadow looms as Meredith searches for a specialty; meanwhile Adele is brought into the hospital after she is found wandering the streets.



161 :08x13 - If/Then

First aired: Feb/02/2012
Writer: William Harper
Director: Jeannot Szwarc

As Meredith puts Zola to bed and falls asleep, she begins to wonder -- what if her mother had never had Alzheimer's and she'd had loving, supportive parents? The reverberations of a happy Meredith Grey change the world of Seattle Grace as we know it. What if she had never met Derek in that bar and he had never separated from Addison? What if Callie and Owen had become a couple long before she met Arizona? And what if Bailey never evolved from the meek intern she once was?



162 :08x14 - All You Need Is Love

First aired: Feb/09/2012
Writer: Jeannine Renshaw
Director: Rob Corn

In the spirit of Valentine's Day, Meredith and Derek try to have a night to themselves when Lexie offers to watch Zola; Callie hands babysitting duties over to Mark so that she can surprise Arizona with a romantic evening; and Ben proves to Bailey that he knows her better than she thinks. Meanwhile, the ER fills with romantics, including a 10-year-old girl who has an allergic reaction to chocolates from her valentine and a man who is hit by a car while chasing down his frustrated girlfriend.



163 :08x15 - Have You Seen Me Lately?

First aired: Feb/16/2012
Writer: Austin Guzman
Director: Tony Phelan

In a final attempt to save Erica's life, Amelia arrives at Seattle Grace to beg Derek for help with the gliosarcoma case; Cristina and Owen engage in heated arguments during marriage counseling; Alex realizes that in order to be a good doctor, he'll need to improve his people skills; and Meredith is given a chance to shine when a man enters the ER after getting his hand stuck in meat grinder. Meanwhile, the residents continue to study for their upcoming oral boards.



164 :08x16 - If Only You Were Lonely

First aired: Feb/23/2012
Writer: Matt Byrne
Director: Susan Vaill
Guest star: Summer Glau (Nurse Emily Kovach)

As Adele's condition continues to deteriorate, Richard considers altering their living situation; an explosion at a local coffee shop results in a busy day in the ER for the doctors; Callie takes Meredith under her wing by helping her study for her boards; Lexie joins Arizona and Alex in peds, as they continue to care for intern Morgan's premature son; and when Jackson snaps at a patient, Mark encourages him to find ways to relieve his stress. Meanwhile, Cristina lets her suspicions get the best of her.



165 :08x17 - One Step Too Far

First aired: Mar/15/2012
Writer: William Harper
Director: Edward Ornelas
Guest star: Summer Glau (Nurse Emily Kovach), Rebecca Hazlewood (Dr. Mara Keaton)

Derek encourages a hesitant Meredith to work with him again in neurology; Jackson's mother, Catherine Avery, returns to Seattle Grace with a urology fellow and develops an interest in Richard; and Cristina becomes increasingly suspicious of Owen's every move. Meanwhile, Alex tries to deny the fact that Morgan may be falling for him.



166 :08x18 - The Lion Sleeps Tonight

First aired: Apr/05/2012
Writer: Stacy McKee
Director: Mark Jackson
Guest star: Elizabeth Franz (Emma), Rance Howard (Martin), Amanda Fuller (Intern Morgan), Danny Strong (Paul)

A lion breaks loose in Seattle, leaving a couple's lives and relationship at risk; Lexie overhears Mark's discussion about moving in with Julia; Teddy begins to take steps towards coming to terms with Henry's death; Callie grills Arizona on her past lovers; and Alex requests to be taken off Morgan's preemie case when she becomes too dependent on him. Meanwhile, Meredith tries to be a support for Cristina as the tension between her and Owen hits a boiling point.



167 :08x19 - Support System

First aired: Apr/12/2012
Director: Allison Liddi

A devastated Cristina presses Owen to confess the intimate details of his affair; Mark takes his new authority very seriously when he steps in as chief for the day and butts heads with Richard over a patient's liver transplant; and Callie deems Meredith ready for the boards, while the rest of the residents continue to stress about the exam. Meanwhile, Callie, Arizona and Bailey plan a much needed ladies night for Teddy.



168 :08x20 - The Girl with No Name

First aired: Apr/19/2012
Writer: Peter Nowalk
Director: Ron Underwood
Guest star: Loretta Devine (Adele Webber), Vanessa Marano (Holly Weeler)

The doctors work on a Jane Doe, who turns out to be the subject of a case that gained national interest; Cristina proves to be the highest in demand as the residents begin their interviews for post-residency positions at prospective hospitals; and Richard is faced with an unsettling realization when he visits Adele at Rose Ridge.



169 :08x21 - Moment of Truth

First aired: Apr/26/2012
Writer: Zakiyyah Alexander
Director: Chandra Wilson
Guest star: Debbie Allen (Catherine Avery)

After eight years of practice, the residents head to San Francisco for their oral boards; sparks fly between Catherine and Richard when they bump into each other at the hotel; Bailey intervenes after Owen and Teddy get into a heated argument about their young car crash patient; and Mark tries to recruit Lexie for one of his cases. Meanwhile, Alex feels guilty for being away from the hospital when Tommy's health begins to fail.



170 :08x22 - Let the Bad Times Roll

First aired: May/03/2012
Writer: Matt Byrne
Director: Kevin McKidd
Guest star: Debbie Allen (Dr. Catherine Avery), William Daniels (Cristina's examiner), Jordan Belfi (Nick)

The residents agonize over their oral boards, reliving every answer they gave during their exams; Arizona's close childhood friend comes to Seattle Grace for medical help; the doctors work on a patient who is missing one third of his skull; and Julia asks Mark to start a family with her. Meanwhile Catherine tells Richard that one of his residents has failed.



171 :08x23 - Migration

First aired: May/10/2012
Writer: Jenna Bans, Mark Wilding
Director: Stephen Cragg

The residents determine their future as they make their final decisions regarding post residency positions; Mark admits to Derek that he is torn between his love for Lexie and the fact that Julia can give him everything he's ever wanted; Ben plans something extra special for Bailey, but she is preoccupied with her work; and Arizona encourages her childhood friend, Nick, to have surgery. Meanwhile a couple on their third honeymoon come to the hospital complaining of mysterious symptoms.



172 :08x24 - Flight

First aired: May/17/2012
Writer: Shonda Rhimes
Director: Rob Corn

Faced with a life threatening situation, the doctors must fight to stay alive while trying to save the lives of their peers; Bailey and Ben make a decision regarding their relationship; and Teddy is presented with a tempting offer. Meanwhile, Richard plans a special dinner for the residents.