Kip Gilman, fleeing the law, and Packy Kerlin, a runaway, meet on the trail. They decide to enter Dodge together to arouse less suspicion. Kips looks for Elena Kerlin and finds her selling herself on Dodge City's version of Skid Row. He gets her help from Doc and after she's cleaned up, she's glad to see Packy. But Kip has problems of his own, for men have come looking to collect the reward on him...
Joe Silva has a talent for making enemies, insulting people wherever he goes. So when someone slips a knife into him it comes as no surprise. But did the old man found with the bloody knife in his hand really commit the murder? The judge seems to think so; he sentences the old man to hang.
Willie Scroggs turns up dead, stabbed and scalped, but Matt's not sure Indians did it. Caleb Nash, an Indian, has been seen in town. After another man dies, Matt goes to see Buffalo Calf, a local brave, but learns frustratingly little - just enough to convince him maybe the Indians did murder the men. But eventually, Buffalo Calf and an Indian woman ride into Dodge with Matt, where they help him figure out what really happened.
Pike Beachum, a wanted criminal, wants to be with Ellie Merchant. But Ellie's married, so Pike has to figure a way to get Joe Merchant out of the picture. He does, but in the end, Ellie's love proves very destructive.
Elsa Poe arrives in Dodge. She's there to meet her fiance Charlie Ross, but Bob Sullins and Art McClain are also interested, and they won't take "go away" for an answer. At a wedding party, someone hits Else over the head and kills Charlie. Sullins and McClain have both left Dodge, but Matt finds them and brings them back, then uses a tricky scheme to figure out who murdered Charlie.
Festus' aunt, Thede, wants a husband. So does Ivy Norton. Thede needs to find a man and Ivy needs to lose one - her overbearing father.
Brad McClain, an old friend of Matt's, comes to town. He wants to buy a business, so Matt introduces him to Jake Bookly. From Jake, Brad learns enough to enact his real plan: steal gold from the mine. What Brad doesn't know is that Matt has received a notice about him and now knows he's an outlaw...
Tom and Mary Stocker plan to go to California as soon as they receive the money Dan Braden owes them. But Dan hasn't got the money - he post dated his IOU by a full year! Tom tries to get his money, Dan winds up dead and people think Tom shot him.
Anderson comes to town. He wants Matt to help him get a killer named Sturney to town so he can collect the $5000 bounty. When they get to where Sturney is, Matt discovers the man dead - and so is Anderson's partner. Anderson just needed someone to identify the body! Then Matt discovers that maybe Sturney wasn't the one who killed Anderson's partner...
Chief Joseph and several Nez Perce braves come to the Dodge House. The chief has pneumonia. A man named Corly Watts, whose brother died at Nez Perce hands, sees an opportunity for revenge. Matt must keep Chief Joseph safe until he can board the train for Washington and a meeting with President Grant.
A wandering minstrel comes to town, just ahead of the Lukins clan, who aim to kill him. Matt must figure out why before he can put a stop to it.
Feuding brothers Cody and Pinto cause trouble Matt must end.
Festus' nephew comes to Dodge City gunning for his uncle - or is he?
Julie Blane, Kitty's friend and former employer, stops in Dodge on her way to Wicheta. She's a big hit with Doc and Kitty enjoys remembering good times, too. So both of them are surprised when she just... disappears.
Matt runs into trouble when a lawyer new to Dodge City begins questioning how he does his job.
Ne'er-do-well Bert Clum learns there are pilgrims camped near Dodge City, and tries to figure out how that can benefit him. He figures they'll be easy marks.
Hattie Silks, once rich and once of New Orleans, plans to take her niece Liz to San Francisco. But they run out of money in Dodge, so Hattie takes a job at the Long Branch. Then she falls in love and decides to settle down. But Liz has other plans...
Amos Caldwell, a preacher who advocates temperance, arrives in Dodge. That spells trouble for Miss Kitty and her Long Branch saloon. But Amos Caldwell has problems of his own to deal with...
John Hooker visits the Scanzano range and demands food and other comforts. Because the Scanzano children collect wanted posters, they realize the man is a wanted outlaw and tell their father, who ambushes Hooker. When Hooker goes for his gun, Scanzano shoots him. And that's just the beginning of his problems...
Doc tries to help Mary Rice and her son Sully, who are fighting for their lives.
Molly McConnell arrives in Dodge City with her young son Willie, only then learning that her husband was killed in a gunfight.
Matt has business elsewhere so he asks Doc to take $1500, reward money for an outlaw, back to Dodge City. But two men attack and rob Doc. A buffalo hunter brings a nearly dead Doc back to Dodge. When Festus captures the men, the townsfolk prepare for a lynching...
Twelve years after the crime, an accused murderer makes a death bed statement that he did not commit the crime. Since one of their paymasters was the victim, the Army asks Matt to investigate, but he receives scant cooperation from the people of Ridge Town.
Jeff Sutro finds the "modernization" of the West a challenge. First he steals a calf and then shoots the owner. He's exonerated for that, but soon manages to get himself into more trouble when someone steals his horse.