Wild Bill Hickock comes up with a plan to clear Matt Dillon name after he is accused by Tom Samples of killing an innocent man.
Matt believes a young man, Fly Hoyt, is innocent of shooting a man in the back despite having an eye witness who swears that it was Hoyt who pulled the trigger.
A Pawnee renegade raid on a farm has Matt wondering who is smuggling rifles to the Indians. But when it's discovered the rifles are outdated and are basically worthless since no one makes bullets for that model anymore, that the Pawnee will reveal get their revenge on whoever sold them the guns.
Mr. Ivy, a freight owner in Dodge may be the suspect of a homestead being torched and the death of his wife when it is discovered that the home owner refused to sell his business to the stranger.
Matt refuses to serve eviction papers on a farmer and his pregnant wife after a judge refuses to stop the process. When another man is given the duty, the farmer and his wife are roughened up.
Kitty is the witness of a gunfight in which she claims a stranger to Dodge City, Jack Portis, drew first on his victims.
A stage coach containing passengers Matt and Chester, is held up by a couple of bandits. During a skirmish a passenger is shot but neither of the lawmen saw the murderer's face. While in Dodge, Matt is positive he recognizes a strangers voice as the shooter.
Ben Tiple, a good friend of Matt Dillon is accused of murdering Will Gibbs, but the only evidence is missing.
When a stranger leading some immigrants planning on settling outside of Dodge wants Matt to give him a badge to avert trouble, he gets suspicious and rides out to their camp to see what is really up.
Hank Blenis is found alone, lynched. Charlie Drain believes he knows who was responsible for the hanging and will take care of it himself since the Marshal seems to be dragging his feet with the case.
Marshal Matt Dillon is hunted down by an old friend when he refuses a bribe to let a fixed poker game be played in Dodge City.
When a man is killed by a farmer who was defending himself against two men trying to scare him off his land, the surviving thug plans to exact his revenge.
After a farmers wife swallows a nail, her son runs to tell Doc Adams. But when the woman dies, Matt fears that Doc's life will be in danger, knowing the man distrusts doctors. He is made a suspect when Doc is shot at while walking the streets of Dodge.
A woman is kidnapped while a stage coach is being robbed by a down on his luck rancher. But the woman's fiancé wants her back, and the kidnapper dead.
When Poney Thompson exacts his revenge on two men who killed his dog, he winds up the prime suspect in the death of one of the troublemakers. But a search ensues when Poney escapes from Chester on the way to jail.
When Matt is shot at while on a hunting trip, he discovers he has wandered into the middle of two feuding families.
Two ranch hands, Rod Allison and Jim Box, end up in a feud when Jim kills their boss. Rod has eyes for Anna, the boss' widow, and is shot by Jim while he steals her cattle.
When Chester's visiting uncle comes to town, Matt plays along with the act that Chester is the Marshal and he is his deputy.
Gideon Seek has lost everything when a pair of rustlers kill all his sheep and burn down his home, but why won't he tell Matt who is responsible?
Doc's former nurse, Abby, has returned to Dodge City. Unfortunately, so has Coney Thorn, a man who Marshal Dillon sent to jail for five years. Thorn has come for his revenge but gets ill in the meantime, and is nursed back to health by Abby.
Dolph Quince sends for Marshal Dillon's help when Jayhawkers invade his herd of horses.
An old friend of Kitty comes to Dodge City. He makes himself her protector and in intent of defending her honor when it is challenged at the Long Branch. But Kitty feels she has no honor worth defending since she is merely a saloon keeper.
Someone has killed Frog-mouth Kate at Ma Torvet's boarding house, and the likely suspect is Billy, a young man who denied her advances from Kate earlier at the Long Branch.
Doc Adams is upset when a new doctor arrives in Dodge City with promises of new miracle cures and lower fees. Feeling slighted by the people, Doc Adams resigns. But when a young boy nearly dies, Matt makes a search for his return.
Joe Plummer tries to frame his boss, Mike Blocker, because of a love triangle involving them and a woman named Tilda.
A gambler, Ed Eby makes it known that the man who kills Matt Dillon would be a legend, in hopes of someone taking up the challenge.
Al Clovis becomes a wanted man after a man he argued with during a poker game winds up dead. He becomes more of a suspect when it's discovered Al has skipped town on a train.
When men start killing each other over a saloon girl, believed to be a good luck charm for those who play blackjack, Matt figures something is up with that and wants them run out of Dodge City.
Matt rescues a woman and her child from the clutches of a buffalo hunter, and then finds himself protecting them from her abusive husband.
Matt Dillon is captured by the Cheyenne Indians after being thrown from his horse while pursuing a murderer, Ord Spencer.
Jake Harbin is chasing down Lee Prentice, using a fake dead or alive warrant poster. After Matt finds Lee wounded, he knows he must protect him from Hardin and Sheriff Ben Goddard, who plans on taking him in custody.
Brisco Cass uses a woman, Bella Grant, as a lure for his brother, Jerry, to get him away from the homestead so he can lay claim to it.
Matt Dillon intervenes when a pair of buffalo hunters are found dead under mysterious circumstances.
Matt gives a man wanted for robbery, Andy Hill, a chance to redeem himself and get a job.
Kin Creed, a stranger to Dodge City, does everything he can think of to egg Marshal Dillon into a gunfight.
Print Asper feels he is being swindled out of his land by a shyster lawyer, and swears he will kill him if his land isn't returned back into his possession.
The Dodge businessmen want Marshal Dillon to keep out of their affairs as they hire an outsider to handle things. But they soon regret their decision when a group of rowdy cowboys come into town.
An Indian, Blue Horse, comes to Matt's aid when he is overpowered by a prisoner he and Chester were delivering across the prairie. Chester was forced to leave Matt behind when his horse broke a leg.
Matt and Chester run across a family massacred by Cheyenne renegades. After Matt is released from mistakingly being accused of the killings by the Cavalry, he heads off to capture the men who sold the guns to the Indians.