Having eluded capture from the FBI, Hannibal settles down in Italy with Bedelia Du Maurier under assumed identities. However, Bedelia is ever uneasy about her company with Hannibal just as a kink presents itself in his new alias.
8 months after being left to bleed to death, Will is in Italy in search of Hannibal. There he finds himself at the Norman Chapel where a heart-shaped body has been left. Still feeling Hannibal's pull, Will is approached by Chief Investigator Rinaldo Pazzi who believes Lecter is the killer he sought 20 years ago: the Monster of Florence.
In his pursuit for Hannibal, Will journeys to Lithuania. Coming to his Lecter's childhood home, he encounters a woman who has long been guard to a dark part of Hannibal's past.
As the dust settles on the aftermath of their near-fatal attack, Will, Alanna, and Jack try to move on from their wounds. As Jack does his best to cope with his worsening wife, a scarred and bitter Chilton approaches fellow survivors Will, Alanna, and Mason Verger regarding retribution against Hannibal.
The hunt for Hannibal begins. Will travels via train with Chiyoh to Florence, as Alanna and Mason use Hannibal's fine tastes to track his whereabouts. Pazzi tries to get in close to find out if Hannibal is the man he's looking for, but his greed may get the better of him.
Bedelia and Hannibal think that their time in Florence is coming to an end. Will's loyalty is questioned by Jack.
Hannibal and Will are brought to Muskrat Farm after being captured in Italy where Mason awaits them.