This new series finds Amanda, a 1200 year old Immortal, up to her old tricks again as a sly thief. Unfortunately, she finds herself framed for murder. A former Detective and current freelance security expert, Nick Wolfe, takes on the chore of hunting her down. The more he gets close to her, the more he will realize that there is more to Amanda than meets the eye.
A Navajo man who once worked as code-talker in World War II is murdered and throw Nick and Amanda together again. The killer's trail leads to an assassin, Mario Cardoza, who seems to never die.
Nick is in charge of guarding the head of a major corporation when somebody tries to assassinate her. The assassins disappearance after his apparent death lead Nick to think this may have something to do with Amanda. Amanda knows the man and is unsure if it is a good idea to help Nick.
Nick teams up with Amanda to steal the plans of a suspect in an industrial theft case and who is now a suspected murderer as well. This won't be easy. The woman suspected has diplomatic immunity and the the plans are in her country's embassy. On top of that, an obsessed Immortal has been stalking Amanda.
An agricultural scientist working on a secret project is murdered. He is the son of an old friend of Amanda's from the 1960's. Amanda wants to help and asks Nick for his assistance. The project is bigger than than both of them assumed and now federal agents are after them for what they know.
While trying to steal artifacts from an exhibit she broke into, two other thieves interfere and cause the alarm to go off and impede Amanda's mission. The two groups are after the same thing but for different reason. Some of these artifacts were left by Amanda herself and one of the thieves is a descendant of the people for which these artifacts were important.
Nick is being pursued by a man he help put away for manslaughter and who is now a suspect in the murder of a District Attorney. This ex-con has always plead his innocence and is now looking to take it out on those who wronged him. Nick investigates further and finds evidence that there may be more to this than he had originally thought and has Amanda help him look into it.
Nick's former captain's brother has been killed by an Immortal because he believed the brother was the reason he and his men were killed in the Gulf War. As it turns out, that is not entirely true and Amanda may have been involved as well. Now the Immortal is after her to settle the score.
Bert Myers enlists Amanda to break into the home of one of his former associate and steal a painting. Bert, unknowingly to Amanda,takes this opportunity to get his hands on some files of his former spy days that could be used to blackmail him. When things go awry and someone dies, Amanda thinks that she may have been used.
The police interrupt Lucy who has just killed a man, Wilson Geary, and is attempting to sever his head. Amanda tries to find out what happened and is caught in the middle of a he-said, she-said triangle that involves the death of Lucy's husband who was an Immortal that had his head taken by Wilson.
Victor Hanson, an Immortal, is responsible for the framing and death of the head of security at a bank where a valuable diamond is being held. The head of security is an old friend of Nick's and he is suspicious. Victor is sweet on Amanda and tries to enlist her expertise for the heist. Nick thinks Amanda's new beau and his friend's murderer are one in the same. The trouble is convincing Amanda.
An Immortal, Korda, from Amanda's past is now a criminal robbing armored cars. Joe Dawson and the Watchers are hard on his heels. Amanda tries to stop him by taking out his assistant first. When she doesn't return, the worst is suspected and Nick heads to Europe to enact his revenge.
Nick, wounded from his altercation with Korda's henchman, finds that Amanda is still alive and they team up to stop Korda who is now setting up a counterfeiting ring. Using World War II resistance maps, they are able to find where Korda is heading his operation and attempt to put an end to him once and for all.
Nick is called in by Bert to help protect an actress who has been targeted for assassination after one of her two guards was killed trying to protect her. The assassin is someone from Nick's past whom he thought he had killed years ago. What Nick doesn't know is that the actress isn't actually the target at all.
Nick is hired by the head of a chemical company, Michael Garrett, and finds out that during and explosion something valuable was taken. The suspect is an Immortal, Talia, who once saved Amanda's live hundreds of years ago. Talia tells Amanda that Garrett is trying to duplicate Immortals and Amanda takes up the charge.
Nick and Amanda are on a job to return a stolen painting to it's owner when it is stolen again. It is another Immortal, Jade, who has taken the picture. Jade is a rival of Amanda's who patterned her life after her as well. For centuries they have been trying to out do the other. There is something odd about this painting, though, and Nick and Amanda try to uncover what that might be.
An Immortal, Markham, escapes from Nick and Bert when they break up his attempt at a kidnapping. Markham, though, leave behind a clue to the truth behind Amanda that could bring down her current facade. Amanda had been partners with him a century earlier and turned him in. Now, Markham wants his revenge.
In a failed attempt to stop a casino heist, Amanda finds out that the culprit is an old partner of hers, Jeremy Dexter, that had completed several “jobs” with her in the past. The Interpol agent that is hot on his trail has a person vendetta to settle as well. Amanda is weary of turning Jeremy in and must make a difficult decision.
Nick and Amanda are hired by a journalist to protect him because assassins are trying to take his life. The leader of the assassins is Rankov, an adviser to a Prime Minister who is in the middle of peace negotiations in the Balkan region. The journalist need Amanda and Nick to break into Rankov's place and steal something for him. Unfortunately, the journalist isn't telling them everything they need to know.
Nick's ex-wife, Lauren, watches her partner killed and Nick helps her pursue the man who did it. The man is an Immortal, Dr. Julian Heller, who is smack dab in the middle of a black market organ ring that he uses to make a substantial amount of money. Heller and Amanda have clashed before and Nick may loose something very dear to him.
Sean, an Immortal, is after Father Liam for killing his mother during the Revolutionary War and is hell bent on getting his revenge. Amanda tries to stop him and is seen dying and coming back to life while fighting Sean. Liam became a priest because of that incident if the Sean's mother lived and was told she did even though she didn't by Amanda. Father Liam now knows the truth and now cannot forgive himself.
Janet, the sister of a hacker who was killed by an Immortal, is a friend of Amanda's and asks for her help to bring her brother's killer to justice. Nick and Amanda decide to take on this endeavor. The Immortal, Payton, in an old adversary of Amanda's that doesn't always fight fair, even in duals with other Immortals. Their clash will lead to a life changing event for Nick.