Raf has to try and step up his game on the AAU. Michael Spence returns to town. Fleur Fanshawe shakes things up on Keller Ward, leaving Sacha feeling undermined.
Guy finds himself trying to get Jac on his side as Raf has a patient requiring complex surgery.
Mo becomes determined to prove that she can swim with the sharks. Serena’s personal and professional lives clash after her mother is brought in for treatment.
Colette starts to consider her future as Jesse gets a place on the research team.
Jesse manages to impress Mo with his teamwork as Serena's mother can no longer recognise her.
Michael's stay in Holby is coming to an end as he tries to stay longer as Adele has trouble with time-keeping.
Adrienne's funeral is taking place as Raf provides Serena with support as Zosia's behaviour continues to go downhill.
As Jesse realises what his fling with Zosia has caused, AAU faces cuts.
Raf feels thrown after Amy has an unexpected request. Dominic ruthlessly risks everything to fulfil his ambitions.
Zosia finds herself becoming emotionally involved with a patient and there are some catastrophic consequences. Mo is advised to follow her heart.
Elliot’s wishes a quiet family Christmas do not go to plan following the arrival of a friend in need. Arthur has step up after those around him begin to fall apart. Ric returns to AAU and ends up treading on quite a few toes.
Dominic’s past comes back to haunt him. Mo needs to find a date for her sister’s wedding. Harry helps Raf see in the New Year.
A family wedding uncovers a family secret as a familiar face rocks Guy's world.
Sacha's daughter arrives as a patient in need of treatment as Jac considers a new start with Emma.
The arrival of Fletch's ex on the ward ends up creating trouble as Rachel and Sacha face a shocking discovery.
Following recent revelations, Sacha does his best to be a good father as Mo does her best to avoid Adele.
Sasha ends up forgetting Rachel's birthday putting his new understanding in jeopardy as Mary-Claire supervises AAU.
Whilst Mo finds herself getting closer to finding out who her own father is, Rachel has leaves the hospital against Sacha's order.
Sacha is feeling fed up with the emotional upheaval of the past few weeks and after Mr Kerrigan turns up at the hospital, he finally loses control. Mary-Claire is determined to keep Harry at bay and sets her sights on a career opportunity.
Elliot is feeling excited as he begins the first official trial of his new device. Darwin has to deal with a major incident and Jonny is stretched to his limits leaving Elliot to make a difficult choice. Arthur and Dominic attempt to prove that they are both up to the task of running triage on Keller.
The news that Mary-Claire could be leaving Holby forces Harry into action as Jonny finds himself in the firing line after a patient's death.
Elliot is back in charge of running Darwin but Jonny ends up getting arrested as Harry is in need of serious treatment.
Jonny finds himself trying to cope with life in prison and tries to help a fellow inmate as Harry ends up lashing out at Mary-Clare.
Raf receives some bad news putting his plans for Harry into disarray as the junior doctors are put through their paces under Serena's guidance.
With Guy wanting Jonny returned to prison, Elliot and Mo stand up for their friend as Harry is keen to join Mary-Claire in America.
Newly released from prison, Jonny returns to work but struggles to control his annoyance at being accused as Essie returns from Germany as Arthur starts work on AAU.
Guy is feeling the pressure as the supercentre is about to pen and he is worried about Jac’s disappearance. Mary-Claire gets ready to face the future in Chicago without Harry. Essie fights to save her relationship with Sacha.
Fletch has high hopes as Evie begins her first day at a new school, until she arrives for treatment after an accident as Annabelle Cooper starts work on Keller as Mo avoids the issue of her birth father causing concern for Adele.
As Guy outlines his plans for the future unaware that Annabelle and Zosia are going to disagree with him over a special case, Mo arranges to meet her dad.