After they declare their love for each other, House and Cuddy decide to spend a day in House's apartment examining their new relationship. Meanwhile, Princeton's status as a Level 1 Trauma Center is threatened when their only remaining neurosurgeon is taken ill, and the team try to diagnose him while wondering where House is.
A young girl who lives her life for her brother, a victim of muscular dystrophy, suffers from heart arrhythmia and is taken to Princeton. House attempts to diagnose the girl but ends up second-guessing himself when Cuddy disagrees with him. Meanwhile, an elderly father and son come to the clinic, each with a hidden agenda concerning the other.
Songs: !!! Chk Chik Chick -- AM/FM
A children's novelist tries to kill herself, but is thwarted when she has a seizure. House, a fan of the books, puts her on psych hold but has to deal with a patient that is eager to die rather than be cured. Meanwhile, House worries that he'll lose Cuddy because they have nothing in common.
The team's newest patient is a wife who suffers from vomiting and stomach pains. While they attempt to diagnose her case, Chase brings in a new female, a psych major who House and Foreman both take offense with. Meanwhile, when Cuddy discovers that House is still seeing his massage therapist and former hooker, she refuses to sleep with him until he loses the woman.
Songs: Doug Paisley -- End of the Day, Jonny Kaplan and the Lazy Stars -- Ride Free
A newborn baby, Kayla, suffers from liver failure and the team discovers that her mother Abbey's blood provides a temporary cure. While they try to identify the underlying cause, House and Wilson end up babysitting Cuddy's daughter, Rachel, and realize that parenthood isn't all it's cracked p to be.
Songs: Bill Callahan -- Night
Cuddy forces House to hire a med school prodigy as his new team member to replace Hadley, but House insists on making things difficult. The newcomer's first case involves a political consultant who has liver failure and a rash, and whose condition steadily worsens. With time running out, House realizes that the consultant's illness is tied to his employer, a senator running for re-election.
A young girl on a dive brings up a jar from a sunken slave ship and breaks it, infecting herself with what appears to be smallpox. When House and his team confirm her illness, they call in the CDC, which puts the hospital under quarantine. However, House soon realizes that the girl has something else... but the only way to confirm his diagnosis is to expose himself to the disease. Meanwhile, Wilson and his ex-wife Sam try to tend to a young girl awaiting chemotherapy whose mother is trapped outside by the quarantine.
Songs: The Black Ryder -- All That We See
A religious patient is admitted to the hospital after vomiting blood, after undergoing a crucifixion which he believes keeps his daughter alive. Meanwhile, Wilson proposes to Sam, Taub believes his wife is cheating on him, Masters gets a lesson on the consequences of her honesty, and House tries to prove that Cuddy is a liar.
A subway hero collapses after saving a woman, and is brought to the hospital. House dismisses heroism as stupidity, but is unable to determine the man's illness. Meanwhile, Cuddy's mother comes to see her daughter and her new boyfriend, and Taub discovers that a new billboard with his face has aroused his wife's libido.
A drill instructor at a disciplinary camp is stricken with back and bladder pains. The team try to diagnose his condition and suspect that one of his charges poisoned him. However, they soon discover that the student is showing the same symptoms... and the two patients share a hidden connection.
When Cuddy's mother Arlene is admitted to the hospital complaining of heart arrhythmia, House refuses to treat her, warning Cuddy that it won't end well. Cuddy insists, and House soon antagonizes Arlene so that she fires him. He continues to proscribe progressively more dangerous treatments behind the attending physician's back, putting Arlene's life at risk. Meanwhile, Taub is forced to take a part-time job with his brother-in-law and suffers a crisis of conscience.
A waitress with perfect memory suffers from paralysis of the legs and heart arrythmia, and is admitted to the hospital. House suspects that her memory is a symptom and tries to pin down the cause. Meanwhile, Foreman is forced to tutor Taub when it looks like the latter will fail his re-certification, and Wilson gets a new roommate.
The Constellations -- Felicity, Wilco
-- How to Fight Loneliness
To get Rachel Cuddy into an exclusive preschool, House volunteers to talk at Career Day. While telling the story of a patient who has coughed up his lung, House pretends to be someone else to avoid liability in a car accident, but things go wrong and he's soon in the principal's office. Intrigued by his exploits, two students get House to tell them the whole story.
A former real estate agent loses his job in the recession and conceals it from his wife, secretly taking a job as a janitor to make ends meet. He suffers from a high fever and swollen joints, and the team tries to determine which job caused his symptoms. Meanwhile, House tries to make a charity gala in Cuddy's honor "fun," Masters and Chase argue over honesty with one's spouse, and Taub and Foreman adjust to being roommates.
While a teenage boy spits up blood for no apparent cause, House chooses to focus on Cuddy, who has a mass on her kidney. Unable to bring himself to see her, House dodges his personal and professional responsibilities. Meanwhile, Taub realizes that the boy is suffering from depression and must decide what to do when he discovers the teenager has considered violence against himself and others.
A champion bull rider is attacked by a bull, but when he's taken to the hospital, it's clear that there is a deeper underlying medical problem. The team tries to diagnose without House's presence, since he's gone to a hotel to get over his breakup with Cuddy by hiring a parade of hookers. As the patient's symptoms grow worse, the team wonders if House's judgment is impaired as he proposes progressively more dangerous diagnostic techniques.
Songs: Peter Gabriel
-- My Body is a Cage, Black Lab -- This Night
A 23-year-old homeless man is admitted to the hospital with a skewed sense of smell, which soon turns into gastrointestinal bleeding. The man refuses to tell the team anything, making it difficult to diagnose him. Meanwhile, in the aftermath of his breakup with Cuddy, House decides to marry a much younger woman to help her get a green card... or so he claims.
House goes to greet Hadley as she gets out of prison after six months, and find out why she was really in prison. Hadley has no interest in talking, and a battle of wills ensue as they go to a spud gun competition. Meanwhile, the team takes on the case of a science teacher with lungs full of blood and a home filled with junk, and discover a secret about the man. While they work on the case without House, Taub renews a sexual relationship with an old acquaintance.
Songs: S. Carey -- In the Dirt
A 16-year-old girl preparing to sail around the world collapses without explanation. Masters, preparing to graduate and become an intern, bonds with the girl and is forced to make an ethical decision when the girl refuses treatment that could save her life, but prevent her from setting a record. Meanwhile, House and Wilson play chicken.
The team treats a lottery winner who suffers from paralysis of the legs, and soon discover that he has cancer... and then he doesn't. Meanwhile, Foreman and Chase make a mutual wager, and Cuddy's mother sues the hospital for her treatment at House's hands.
The team takes on the case of a missile design expert suffering from a wide variety of symptoms. She fails to show improvement and the team looks to House, only to discover that he's obsessed with the case of a boxer who collapsed during a fight.
Songs: Sonny Boy Williamson -- Unseen Eye
Hadley's prison cellmate comes to her for help when she receives a knife wound. However, her condition soon grows worse and Hadley calls in Chase for help. Meanwhile, House takes extreme measures to remove the tumors growing in his leg, while Taub receives news from his girlfriend and takes it poorly.
The team treats an esteemed performance artist, but discover that she wants to perform a new piece using House as her unwilling assistant. Meanwhile, House vows to change, but when Cuddy and Wilson insist that he talk out his feelings, he takes a radical approach to making a new life for himself.
-- Got Nuffin