Melinda, a rebellious girl, has a severe allergic reaction and ends up going into shock because she is immunocompromised from a heart transplant she had earlier in life. Soon Melinda's condition worsens and she becomes paralyzed, with the paralysis slowly moves up her legs. To make matters worse, her overprotective mother and boyfriend are constantly fighting about her condition. The team must find a way to stop the paralysis and figure out what is wrong with her before it gets to her heart. Meanwhile, House and Wilson are still having problems with their living arrangement.