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Obnoxious 16-year-old chess prodigy Nate is admitted to Princeton-Plainsboro suffering from intense head pain that came on after he attacked his opponent during a speed chess tournament. Nate's mother tells the team that Nate has been having behavior problems ever since he became a teenager, and House suspects the behavior is a symptom of cluster headaches. As House's team carries out further testing to see why he might be having the headaches, Nate manages to offend and annoy each doctor on the team. As Nate's illness progresses, his liver and kidneys begin to fail. To narrow down the list of possible diagnoses, House carries out a series of unconventional and eccentric tests of his own, including engaging Nate in a game of chess to try to beat him at his own game. Meanwhile, Foreman's frustration with House reaches a new level when he believes House sabotaged his job interview with another hospital, and Cuddy makes Foreman an offer she's sure he can't refuse.
Nate: So do people watch what they say around you?
Dr. Foreman: Because I'm black?
Nate: No, because you're gay.
Dr. House: (to Cuddy) You are one evil cunning woman. It’s a massive turn-on.
Dr. House: (to Cameron) If you want to curry favor with me, avoid discussions of other men’s testicles.
Dr. House: Arrogance has to be earned. Tell me what you’ve done to earn yours.
Nate: I can walk.
Dr. House: I don’t bleed out of my penis.
Dr. House: The kid's not a cliché. Anybody can get in a fight after losing. It takes real creativity to beat up someone you just beat.
At the beginning of the episode, Chase is shown writing the word RAGE on the board. The picture cuts to House then back to Chase at the board. The word RAGE that's on the board now, is not the same as the one shown previously. It was rewritten.