At a Jewish Hasidic wedding, Ron and Yonatan are united dance at the reception. However, Roz is suddenly taken ill, starts urinary bleeding, and falls to the ground.
Wilson arrives at work only to find House waiting for him to interrogate him about Amber, his new girlfriend. Wilson tells him to talk to Amber, and he’s not concerned now that he’s found someone that breaks the pattern of his previous wives. The team then go over Roz’s record and House suspects she tried to kill herself. Taub and Foreman search her home for possible poisons she might have taken and they discover Roz cut several records and took drugs. Thirteen and Kutner talk to her and she reveals that Yonatan knew about it.
Amber returns home to find House waiting for her, with a theory that she’s using Wilson to get to House to get hired. Then he wonders if she’s trying to get revenge on House. Amber admits nothing and House has to leave.
Poison tests prove negative and House notes that she went directly to the Hasidic lifestyle months earlier, which suggest a mental problem and porphyria. They start treating her while they do the tests, and Yonatan and Roz are both curious to know why. When he finds out, Yonatan goes to Cuddy and asks for a new doctor, since House believes her religious beliefs are a symptom. House insists Roz’s change is significant but Cuddy starts to override him. However, Roz crashes with respiratory problems.
The next morning they check Roz’s new status and discuss Wilson’s relationship with Amber. House wonders if it’s Lupus and suggests they run her through a stress test: if she has Lupus, she’ll have a heart attack. They go ahead and run the tests.
That night, House “accidentally” runs into Amber and House and Amber invites him to sit with them. As Amber goes off to take charge of getting their reservation taken care of, House and Wilson discuss the relationship and House notices Amber calling him over. House suggests that Wilson likes her conniving personality… just like House’s. Even House seems disturbed by that.
Taub administers the stress test to Roz while Yonatan wonders if House was right… and is concerned that the treatment will undo the “change” and restore her to what she was like before she became Hasidic. The stress test proves negative, disproving House’s Lupus theory, but Roz collapses with leg pain. They run MRIs to test for possible blood clots which proves negative, and House has Foreman adjust her IV, lighting up her limbic pleasure centers and suggesting she’s a masochist. Roz says she was praying, which might account for the brain activity. As she gets up, Roz crashes again and then is back to normal within seconds. House gets her up on her feet… and she crashes again.
It’s back to differential and Kutner suggest electrical problems with her heart. House orders tests then spots Wilson and goes after him. Wilson suggest that House is right and would approve of Amber if House didn’t loathe himself so much. House accuses Amber of being needy and Wilson denies it, and then wonders why House keeps finding a new argument every time Wilson agrees with him.
The team test the heart and Taub considers whether Hasidic Jews have something going. Roz interrupts to berate them for gossiping and then says she could hear Foreman and Thirteen talking interesting from inside the MRI.
House goes to see Cuddy and suggest she sleep with Wilson, and warns Wilson saves women and betrays women. Cuddy points House is worried that Wilson will change and not need House.
The team administer a powder test and Yonatan is reluctant to see her naked. Thirteen tries to console him but he refuses to accept her words, saying his beliefs are legitimate. Roz’s body temperature drops radically due to hypothermia.
Back to differential and they wonder why her body is doing the opposite of what it should. House suggests they do the opposite, and it might be Addison’s. They run a cortisol stimulation test while Cuddy checks on Wilson and his relationship. She tells him the same thing that House has been saying, shocking Wilson.
Thirteen goes to check on Roz and notices she has a swollen abdomen, indicating internal bleeding. Chase checks the MRI files and suggests they open her up and search for the problem. She refuses to undergo surgery until after sunset, so she can share one <i>Shabbat</i> with her husband. Yonatan tells her to do the surgery but she insists on waiting eight more hours. With time running out, Taub insists she isn’t suicidal and Chase suggests that they pretend its sunset so she can have her <i>Shabbat</i> dinner.
House calls Amber in and offers her the job if she can solve the case… and drop Wilson. She insists she’s getting respect from Wilson, and chooses him over the fellowship. However, as she leaves she suggest it’s DIC, and House notes she’s changed. The platelet count rules out her theory, but they can’t come up with anything else… until House realizes something. He has Roz stand up and simultaneously puts pressure on her right side… and she stabilizes. It turns out she has a floating kidney that came loose during the wedding, and none of the scans picked it up since she was always lying down when they did the test.
House then drops in and tells Wilson he could do worse. He heads out as Wilson wonders if House is acknowledging that anyone can change. House says he doesn’t, and Wilson realizes he could make a long-term relationship with someone other then House. He figures House has thought of all of this, and is still going along with it as a gesture of self-sacrifice. House denies it and leaves.
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