Chef Anthony is teaching a cooking class with his assistant Dana Miller when she starts to choke. She quickly diagnoses her condition and says that she’s a doctor, and then collapses as she says she needs a doctor.
Thirteen wakes up in bed with Foreman, and finds him watching her.
Wilson is washing dishes ion Amber’s apartment where he’s still living months after she’s died. He sees her coffee cup on the counter and leaves it there.
House gets to work and finds that the elevators are closed for maintenance. He limps up the stairs to the office where Foreman, Thirteen, and Taub are going over Dana’s case. She’s suffering from pneumothorax and Thirteen points out that Dana is a cancer researcher close to coming up with a major breakthrough. She insists that they should take the case and an out-of-breath House goes over it and suspects asthma. As he orders steroid treatment, Kutner casually walks in and House realizes the elevators are working normally.
Taub and Thirteen test Dana for pneumothorax and she explains that she’s no longer a doctor. Eight months ago she had uterine surgery for a myoma. After that she decided that her life as a researcher wasn’t’ satisfying and she quit and took up work as a cooking assistant.
House confronts Curry who is busy watching her baby Rachel on her webcam. She admits she had the janitor put fake signs on the elevator to get revenge on House for forcing her to work because she’s the only on who can deal with him. Rather than insult her or vow revenge, House just walks out and gets on the elevators.
Dana tests negative for asthma and the team wonder if there’s a hole in her lung left by the IV during her uterine surgery. They think it’s a shame that Dana quit and House insists that they all do what they do out of self-interest. They next suspect pulmonary fibrosis and prepare to a biopsy. House talks to Foreman privately and asks if he sabotaged the clinical trials to put Thirteen on the real rug rather than the placebo. Foreman denies it and goes to test Thirteen as part of the trials. She complains about headaches but says it can’t have anything to do with the treatment because (she thinks) she’s been on the same drug for several months and nothing would come up now.
When Taub tells Dana they’ll have to do an open-lung biopsy, she refuses because it will keep her in bed and she has things to do with her new life. He says that he’s happy with her life but she says she wasn’t happy with hers so she made a change. Dana notices a pain in her side and Taub determines that her live is leaking blood into her stomach.
As House goes into his office with his team, he stumbles over a tripwire and falls to the ground. He ignores it and the team, surprised, figures that he must already know who did it. Foreman checks the scans and notices a possible granuloma that could cause the bleeding of the lung. As they go to run tests. As he looks over the scan, House notices that Thirteen has to turn her head to see it. As Foreman leaves, House warns him that she’s losing her peripheral vision and he needs to deal with it.
Wilson checks in on house and wonders at the fact House isn’t doing anything to Cuddy. House claims that there’s nothing he can do because there’s nothing he can gain. He claims he’s just going to let Cuddy tire herself out but Wilson wonders if he’s guilty about keeping her from her baby.
Wilson visits Dana, who he met at a cancer conference. He complains that he’s trying to keep patients alive long enough for a cure that now she’s never going to find. She says that she deals with that a lot but she had to get out of the rut in her life, and wonders what rut he’s stuck in.
Taub is at home with his wife when he brings up having children. She reminds him they agreed not to have children years ago and Taub says that he’s been reconsidering his life recently but agrees to still abide by her decision.
Foreman goes to the lab to test Thirteen’s vision and confirms House diagnosis. She figures out she’s on the real drug and says she’ll have to be taken off of it, and Foreman has no choice but to explain that the trial sponsors think she’s never been on it, and that he switched her from the placebo to the real thing. She can’t understand how he care for her so much that he’d risk his career and says she’s not ready for someone to feel that way about her.
When Foreman goes to see Dana, he notices that she’s been scratching at her scalp. She complains about itchiness but when he checks her head he realizes that she’s scratched through the skin and bone and brain matter is leaking out.
Back in differential, Thirteen complains about a headache, and House figures that since Dana scratched through the skin and pain receptors but still feels an itch, there’s a problem in her brain receptors. He tells the team to run a MRI to confirm and then notices that Cuddy has stolen his cane. He sees a nearby mop bucket and gets an idea.
Foreman confronts Thirteen about the headaches and discovers that she’s getting worse. She accuses him of having hurt feelings. However, he points out that her symptoms are the main concern and she’s getting worse despite the fact she’s off the trial drug.
House brings the mop bucket to Cuddy’s office but tries to assure her that working mothers are more fulfilled. She doesn’t buy it and tells him to dump the bucket water on her carpet and get revenge back. He just leaves.
Foreman runs Thirteen through the MRI and notices something seriously wrong.
House arrives at differential using a metal hospital cane support and discovers that Thirteen and Foreman aren’t there. Foreman comes by to get his coat and immediately leaves over House’s objections. House suggests they shock Dana’s nerves and goes after Foreman, who explains that he discover a tumor in Thirteen’s optic chiasm. He’s planning to go to the drug company but House tells him not to be an ass by throwing away his career: Thirteen is going to need him as a doctor. Foreman goes to back to his apartment to meet with Foreman and discovers that she’s gone totally blind.
The next morning, Wilson finds House sleeping in Wilson’s office. House wakes up and explains that Cuddy pretended to be his wife and had all of his utilities shut down. House Wilson notes that House’s non-response response isn’t working out for him.
Taub and Kutner tell House that Dana is having spinal shocks. He suspects a hemangioma and tells them to test, then goes to find Foreman at his apartment. He finds Thirteen there and realizes she’s blind. She explains Foreman is going to the drug company and House tells her that Foreman did what he did out of love on House’s advice, and if she cares about him then she should call and tell him to come back. She agrees and calls him.
Wilson complains to Cuddy about her treatment of House. She says she’s miserable because she has to work and manage House, and Wilson tells her to fire House if she feels that way. She admits that House is goof or the hospital and Wilson says that how House is is what makes him good for the hospital.
As Foreman and House prepare Thirteen for radiation treatment of her tumor, House notes that Foreman didn’t take his lover’s feelings into consideration. They insert the catheter into her chiasm and place the radiation isotope.
Kutner and Taub find dozens of hemangiomas throughout Dana’s body, indicating cancer. He tells them to consult with Wilson and run a biopsy. Kutner wants answers about what’s going on with Foreman and Thirteen, figuring House isn’t telling them anything because he’s worried an doesn’t want them to. He insists that he’s going to check with Admitting to find out.
As Wilson prepares the biopsy, he apologizes to Dana for getting mad at her earlier. He admits he’s still living in his dead girlfriend’s apartment and is stuck in a rut. He wonder how to get unstuck and she says the worse thing to do is nothing at all. When he checks one of the hemangiomas, it starts bleeding.
Kutner visits Thirteen and tells Foreman to go to the drug company. Kutner isn’t impressed by the fact that Foreman is now letting Thirteen call the shots after he lied to her about the drug trial.
Wilson tells House about the bleeding hemanigomas as they get an alert that her heart has stopped. Dana’s system is bleeding into her heart and when they try to stabilize, she bleeds from the eyes and nose. They’re unable to keep up with her blood loss and she’s too weak for surgery. House tells them to cut off the blood to the tumors, despite the fact it’ll harm her healthy tissue.
Cuddy gives House his cane back and apologizes, saying he is who he is. House goes back to normal himself and starts insulting her, figuring she’s on her “Aunt Flo.” He gets an idea and leaves to see Dana. Cuddy figures that’s as good as it’s going to get in the way of an apology and says that’s who he is.
House goes to Dana’s room and finds her menstrual pads. He explains that when she had uterine surgery, endometrial cells leaked in to her bloodstream and spread throughout her body. When she went on her period, the cells swelled up and bled as well, accounting for all her symptoms. Once she’s through her period, they can operate and remove them.
Foreman watches over Thirteen after her radiation treatment. She wakes up and realizes that she can see again.
Taub talks to Dana and wonders what she was thinking of when it appeared she was going to die. She admits she wasn’t worried about it and tells him to worry about what he’ll think on his death bed on that day, and worry about living and being happy now.
Foreman calls the drug company and tells them what happened. House visits Foreman later and figures out what he did. The drug company will dismiss Thirteen’s trial results and watch out for tumors in future patients, but still release the drug. As long as Foreman never participates in clinical trials, they won’t file for him to lose his license. House limps off, satisfied that Foreman is still working for him.
Taub’s wife wakes up to find Tub watching her. He admits he’d like children, but he can’t live without her.
Thirteen and Foreman are in bed together, and she teases him that he snores.
Wilson finally puts away Amber’s coffee mug.
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