At a music studio, singer Brandy is waiting for legendary jazz musician John Henry Giles to arrive. She assures her band that she got John Henry to come to provide accompaniment.
John Henry and his long time companion, Cora, are driving to the studio, and she wonders if Harry is up to it. He says they'll find out. They arrive, John Henry in a wheelchair, and they play the track for him. He starts up on trumpet, but then starts to choke. Cora runs to his aid and they call an ambulance.
House comes to see Cuddy and tells her that he wants in on John Henry's case. He claims he's not a fan, but is intrigued by the paralysis afflicting John Henry for the last two years. Cuddy tells him that the hospital is only concerned with John Henry's pneumonia, the cause of his choking. Marty Hamilton is John Henry's primary physician, and is the one dealing with it. Hamilton has asked for the team, and Foreman did his residency with him. Cuddy insists that it's Foreman's case.
House sits and watches as Foreman runs differential on the pneumonia with Cameron and Chase. Foreman orders broad-spectrum antibiotics, but House wants to discuss the paralysis. Hamilton has diagnosed it as ALS, Lou Gehrig's Disease, but House points out that it's untreatable. He takes over the board and tries to run differential, against Foreman's wishes. He suggests they do a MRI, but Foreman overrides him, insisting that ALS predicts the pneumonia.
Foreman checks on John Henry, who asks his opinion on House versus Hamilton. Foreman tries to hedge his answer, but John Henry doesn't buy it. Cornered, Foreman says that he won't do a MRI and that he agrees with Hamilton. John Henry asks Foreman to bring him a do-not-resuscitate order so he can sign it as soon as possible.
House is in his office listening to John Henry's albums when Foreman comes in to inform him about the DNR. He admits that he didn't tell John Henry about the MRI, and House points out that since ALS is a death sentence, it's hardly surprising. When Foreman says that John Henry is refusing treatment, House points out that if he doesn't do anything, it doesn't matter which one of them is right. He suggests a possible treatment of steroids and IVIG and then goes back to his music. Foreman checks on John Henry and then authorizes House's treatment.
Later, House is at the clinic meets with a patient, Willie, who wants Viagra. House notes that he has diabetes, even though Willie didn't admit to it, He gets a Code Blue on John Henry, and gives Willie a prescription for Viagra anyway, figuring if Willie wants to kill himself, that's up to him. Foreman figures John Henry is having respiratory failure due to the IVIG, and they can't revive him because he's DNR. House arrives and tells them to revive John Henry. When they refuse, he intubates the musician himself over Foreman's objections. Cora comes in and they reluctantly tell her that House saved John Henry's life.
Once John Henry is stabilized, the team goes back to the conference room. Foreman insists that they violated the DNR, but House insists that John Henry's thyroid levels indicate that he's depressed and thus incompetent to make the decision. When Cameron tries to defend House's theory, Foreman tells her not to. House points out that John Henry signed the statement because he was afraid of dying painfully of ALS, and his problems from IVIG had nothing to do with that. He wonders if Foreman is worried about looking bad with his old boss, and Foreman storms out. House returns to differential and asks for theories, and Chase suggests Wagner's. but a woman comes in and serves him with a restraining order to stay away from John Henry, and informing him he's being charged with battery. Unimpressed, House tells Cameron to test the remaining blood they have for CANKA and confirm on Wagner's. Since Chase is still suctioning John Henry's lungs for pneumonia, House tells him to do a biopsy, and then move John Henry closer to the clinic so he doesn't have to go there.
Later, House goes to see Cuddy and yells at the top of his lungs because he can't get close enough to her because of John Henry's location. She's well aware of what he's up to, and offers him a lawyer. He wonders if she's okay with what he's doing, and acknowledges that she knew he was insane and set aside a budget for a lawyer. House asks if she can help him run some test, and Cuddy warns him that Foreman called Hamilton, who is flying in to pull the plug. House admits that he needs a lawyer.
In court, Cuddy's lawyer, Morris, brings a motion requesting that John Henry stay on life support. Judge Winter notes that House has been charged with battery, and House explains. Winter notes that House is the one who forced Henry onto life support, committing battery in the process. Morris argues that if John Henry dies, House's Sixth Amendment right to face his accuser will be violated. While Cora's lawyer, Morris, objects, Wilson asks what House is doing. House says that he's playing for time, and Wilson accuses him of having a Rubik's complex, an obsession with solving puzzles. Meanwhile, Morris tries House's claim that John Henry was suffering from depression due to thyroid levels, and Winter notes that Foreman witnessed the signing. House jumps in to admit that his staff is idiots, Winter doesn't buy it, and House tries to interrupt again. He asks if Winter's family has a history of heart disease, and notes that his fingers show signs of clubbing. House suggests that Winter see his doctor, and then sits down. Distracted, the judge grants Morris the motion. Afterward, Wilson notes that he didn't see any signs of clubbing, and House points out that all families have a history of heart disease.
Back at the hospital, Chase reports that biopsy only shows inflammation. House orders treatment for Wagner's since they can't do any more tests. When Cameron asks if he wants them to jeopardize their medical licenses to administer the treatment, House does it himself. John Henry is unable to speak, but shakes his head, but House continues. As he finishes, Hamilton arrives and asks to see House in his office. He explains that he checked for Wagner's and that it's time for House to let go, and that he's taking John Henry off the respirator. Foreman comes in and greets Hamilton, and House informs them that he has a court order so he can face his accuser. Hamilton responds by saying that the charges against House have been dropped. House insists that John Henry doesn't have to die, but Foreman says that it's not Wagner.
House and Wilson watch as Cora, Foreman, and Hamilton prepare to pull the plug. Cora kisses her husband one final time, and Hamilton removes the respiration tubes. As they watch, John Henry starts breathing on his own. House realizes that it's not Wagner's, and he's wrong again.
Later, they determine that one of John Henry's arms is now paralyzed. The team goes back into differential, and Cameron notes that progression of the paralysis confirms Hamilton's diagnosis of ALS. House doesn't believe the new paralysis is connected to the old one, and Cameron suggests it might be a stroke. House wants to check for a stroke, but Foreman notes that John Henry doesn't want House treating him. In response, House notes that John Henry dropped the restraining order. He waits until Hamilton leaves, and then goes to see John Henry. The musician tells him to get out, and House admits that the thyroid condition wouldn't account for his depression. He asks John Henry to let him find out what's wrong with him, If he wants to kill himself after that, House will help. John Henry refuses, insisting that he performed with Brandy to see if he could perform, and he realized that he couldn't. He's explains that House is just like him: obsessed, with nothing else to lift for. House agrees, but then wheels him out and takes him to the MRI room.
Hamilton and Foreman have lunch, and Hamilton asks if he enjoys working with House. Foreman ducks the question, and they discuss if he's seeing someone. Hamilton then asks if Foreman would enjoy L.A. Later, Foreman tells Cameron and Chase that Hamilton has offered him a full partnership. Chase wonders why he didn't take it, and Foreman claims that he's honoring his commitment to the team. He wonders if they would take the job, and they're fine with working with House. When Foreman points out that House doesn't care, and just assaults a patient and then moves onto the next differential, Cameron doesn't see the point. Foreman insists that he wants House to realize that his decisions matter. They spot the embolism caused by a stroke, but Foreman isn't impressed. He suggests that House should learn some humility... just as House comes in. They can bust the clot with CPA, and determine if that helps John Henry's arm. House smirks at Foreman and leaves.
Foreman explains the blood thinner treatment to John Henry, and admits it could cause bleeding into his lungs. John Henry refuses, noting that if he doesn't have his air, he doesn't care about his arm. Foreman then suggests going in and removing the clot, and Hamilton admits that it won't hurt his client's lungs. Either the cure will kill John Henry or make him better, so he wins either way. John Henry agrees and Foreman goes to set up the procedure.
Cameron and Chase perform the surgery, inserting the wire up through his carotid and into his brain, and successfully break up the clot.
Foreman goes to see House and describe Hamilton's offer. House isn't impressed, and notes that he isn't impressed by humility. They get a page and go to see John Henry. He can use his arm, and he thanks them. House, unimpressed, tells them to leave a message next time. As he goes, he pats John Henry's leg, and the musician says that he can feel it.
House tells the team that sometimes patients get better, and they try to figure out what. Hamilton dismisses it, and warns Foreman that House will take credit for it. Meanwhile, House, Chase, and Cameron try to figure out what drugs they're giving could cause it. They'll hold back the medicines one at a time and see which one makes him worse. House tells Foreman that Hamilton's own ALS treatments can't be helping, since John Henry would have recovered long ago.
House and Wilson watch soap operas and chat, and Wilson notes that now House is in a hurry to withhold treatment. Hamilton comes in and asks House what medications he was giving him. House refuses, and warns that if Foreman tells him, he'll force him to fulfill his two-year contract. However, House gets an idea and realizes that Hamilton needs to know what medications he has John Henry on. He checks on John Henry and confirms that his paralysis is back. House has the team put John Henry back on steroids, the first thing they gave him and then took off, and run another MRI to see what changed. Then he says that he and Foreman need to talk.
As they run the MRI, Chase wonders if House will hold Foreman to his contract. Cameron figures he'll let Foreman go, since keeping him would mean admitting that he needs him. Then they spot something on the scan.
House tells Foreman that he checked out Hamilton, and asks if Foreman thinks that Hamilton is a better doctor. When Foreman says that Hamilton forgives, and forgave him his mistake in treating John Henry, House says that Hamilton doesn't, He insists that he holds Foreman accountable, whether he's right or wrong, while Hamilton moves on. Before Foreman can respond, Cameron and Chase come in and reveal that John Henry now has an arterial-venus malfunction pressing on his spine. They realize that it wasn't there before. The steroids removed the swelling temporarily, curing the paralysis. Now that they know where the AVM is, they can remove it and John Henry will walk.
After surgery, John Henry slowly regains the use of his legs. When he checks out, he sees House in the lobby, taking Vicodin. John Henry thanks him, and figures that House wasn't the most cheerful guy even before his leg was messed up. He gives House his trumpet and wonders where he can buy a second cane, and House assures him he won't need it.