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Cuddy's young handyman, Alfredo, ends up falling from her roof and she soon joins the team in figuring out what caused him to fall in the first place. Cuddy is racked with guilt, even more so after House must amputate his hand after it becomes infected, because he is the sole provider for his family. After taking a trip to his neighborhood, the team may figure out just what caused Alfredo's illness in the first place.
House: You see the world as it is, and you see the world as it could be. What you don't see is what everybody else sees. The giant gaping chasm in between.
Dr. Cuddy: House, I'm not naive. I realize...
House: If you did, you wouldn't have hired me.
Dr. Chase: You two are just too nasty to each other not to have been...nasty.
House: Hey, I can be a jerk to people I haven't slept with. I am that good.
House: Oh my God. She’s got pictures of you in here. Just you and…it’s like some kind of weird shrine.
Dr. Chase: You’re kidding.
Dr. Cuddy: You figure a perverted sense of guilt makes me a good boss?
House: Now would the world be a better place if people never felt guilty? Makes sex better. (points to Stacy with his cane) Should have seen her in the last months of our relationship. Lot of guilt. Lot of screaming.
House: Do I get bonus points for acting like I care?