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After Dr. Sebastian Charles, who is renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to the hospital after collapsing, he immediately determines all the symptoms are from TB. House does not believe it and orders rounds of tests. Soon after the case gets the attention of the media, Dr. Charles refuses any more tests and medication in order to bring to light about the medical needs in Africa. Cameron actually sees eye to eye with Dr. Charles, but House ends up making his situation worse. Meanwhile, Foreman fills in for House in the clinic with mixed results.
House: That is exactly why the patient shouldn't be in the room. If you can't tell a man that his cologne makes you want to puke, how are you going to tell him that he's an idiot?
Dr. Cameron: He's not an idiot.
House: Sure, you say that now, while he's in the room.
House: Every minute that we refuse to love one another, another puppy cries another tear.
Dr. Wilson: You're just mad that he's closer to a Nobel Prize than you are.
House: And yet I've nailed more Swedish babes. Crazy, crazy world.
Dr. Wilson: It's not just a trip to Stockholm, you know. It comes with a cash prize.
House: Seriously? No wonder everyone's going after that peace thing.
Dr. Cameron: You don't think objectivity's important?
Sebastian: I think doctors like House cling to objectivity like a three-year-old to a blanket; don't get too worked up, stay calm, stay cool and maintain that correct perspective. The only flaw in their argument is when you have millions of people dying the correct perspective is to be yelling at the top of your lungs. Sorry, my head is killing me.
House: I saved his life. That means I get credit for every life he saves from here on out.
House: Judging by the scratches on your hands, I'm guessing...new cat.
Mandy: It was my mother's. She's dead.
House: You keep a dead cat?
Title: TB or Not TB
The episode title is an obvious pun of Shakespeare's famous quote from Hamlet, "To be, or not to be".