A young teacher suffers from seizures in front of her class of kindergartners. She is taken to Princeton Hospital, where a world renowned doctor, Dr. Gregory House is assigned to her case. With his team of young doctors, House finds a tumor within the teacher and it turns out that she hardly has any time to live.
A 16-year-old patient comes in suffering from double vision and night terrors. House dismisses the kid but as he's leaving the hospital the patient suffers from myoclonic jerks. House thinks that the patient may be suffering from Multiple Sclerosis, but the night terror hallucinations disprove the diagnosis. As he gets worse, Cuddy is horrified at the fact that House is making bets on the child's paternity, which might be the key to solving the case. Meanwhile in the clinic, House is having to deal with a man who is trying to set up a lawsuit and a mother who refuses to give her baby vaccinations.
Brandon is 22-year-old male, who ends up passing out after having rowdy sex with his fiancée. He complains of abdominal pain, nausea, and suffers from fever and low blood pressure. House and Foreman test out their theories, but after a dangerous drop in white blood cells, they realize they must find a solution and soon. Meanwhile in the clinic, House must deal with a boy and an unusual situation involving a MP3 player.
After two newborns in Princeton Plainsboro's maternity ward fall ill, House takes on the case. Soon the illness has spread to six babies, all of which have high fevers and low blood pressure which could mean that these newborns will die in less than a day. House wants to test which medicine works better, by putting one of the babies on a different medicine, despite the fact that this experiment may have a fatal effect, which angers Dr. Cameron and the rest of the specialists.
House has a new patient whose hands are red with boils. She is a nun and all of her fellow nuns believe her condition to be stigmata. After what seems to be an allergic reaction to the medicine House prescribes, Cuddy orders him to research the case. During an MRI, the nun starts to suffer from convulsions. House wonders if her past is coming back to haunt her, as the doctors provide different theories about the nun's condition. However, only one of them has the correct answer.
Lucy Palermo is a schizophrenic mom with deep vein thrombosis and also displays mixed symptoms, including a tumor, but House realizes her cannot figure out what is wrong with her. After an anonymous call to Social Services, House begins to question whether Lucy is really schizophrenic, and causes her son, Lucas, to blame Dr. House for making the call which will take him away from her. House decides to then take Lucy off all her medication and then secretly sends Foreman and Chase to search her apartment for clues. All of this happens on House's birthday which he is trying to forget, but no one will let him.
After a husband finds his wife in bed and cannot wake her up, he rushes her to the clinic. Puzzled by her symptoms, they consider everything from cancer to rabbit fever. When all the treatments fail, House comes up with the diagnosis of African sleeping sickness. The woman will die without the proper treatment but neither she nor her husband admit to having an affair because the only way she could have contracted the disease was through sex.
A young high school male comes in to the hospital with a lethal poisoning, but neither House or the rest of his team can find out what has caused it. House decides to send Cameron and Chase to the teen's home to find the hot new drug House is sure he's taking. They don't find drugs, but do find something that would explain his symptoms. That is until another student comes in with the exact same symptoms. Meanwhile, an 82-year-old patient becomes obsessed with House who is trying to figure out the basis of her renewed fascination with her sexual feelings.
After jazz musician John Henry Giles checks into Princeton Plainsboro Teaching Hospital believing he's dying from ALS, he signs a DNR to avoid a slow death. House disagrees with the diagnosis then violates the man's DNR to save his life. House ends up in court and the man's paralysis ends up getting worse. Soon though, the man begins to get better for no reason, leading the team to ponder how this is occurring. Meanwhile, Dr. Foreman meets with an old friend who ends up offering him a West Coast partnership and he might just take him up on the offer.
Dr. Foreman is convinced that a homeless woman is faking seizures just so she can get a free meal. However, Dr. Wilson is determined to keep her from falling between the cracks of the system. Soon, her symptoms actually do get worse, and House and his team feel that getting an accurate history of the patient will be the key to solving the mystery. Foreman believes that she has contagious meningitis, but when he goes to tell her, she has disappeared. She soon returns, after being tasered by police, which ends up giving House a clue to the real diagnosis. Meanwhile, House is supposed to be helping two med students with their case studies, but chooses to blow them off with mixed results.
House decides to take Cuddy's challenge and stops taking Vicodin for a week in exchange for no clinic duty for a month. House's withdrawal symptoms become increasingly severe as he and his team have to figure out why a 16-year-old boy won't stop bleeding after a car accident. Foreman and Cameron begin wondering if House is stable enough to even be attending the patient.
Although baseball player, Hank Wiggen thinks he just has a badly broken arm, it turns out he has some severe bone loss and his career is over. Soon, House believes that Hank is using steroids, even though he swears he has not. Hank's kidneys begin to fail and his wife says she will gladly donate one of hers, but if she does she will have to abort her still early pregnancy. Hank, after hearing this, tries to kill himself. It's up to House and his team find out what the true problem is and soon if this pitcher's life, as well his career, is going to be saved. Meanwhile, Foreman dates a pharameutical rep and House ends up getting stuck with two tickets to a monster truck rally and ends up going on a "date" with Cameron.
After a 12 year old boy is convinced he is cursed because a Ouija board revealed to him that he is going to die soon, his father, who just so happens to be major financial supporter of the hospital, makes unbelievable demands of House and his team as they struggle to find a diagnosis for his symptoms, which include a rash and a week long fever. Chase becomes outraged when House invites his father from Australia to help him with his diagnosis. House is shocked to see that Chase and his father are not close at all. After House finally diagnoses him, the boy begins to believe that his father might not be so truthful after all.
The hospital is turned upside-down when billionaire entrepreneur Edward Vogel ends up buying his way into becoming Chairman of the Board. Vogler sees the new job as a way of making the hospital a new biotech venture. This means that they would no longer need the services of Dr. Gregory House. Meanwhile, a powerful young woman ends up paralyzed for no reason that anyone can explain. Soon House is on to her deadly secret, but he wonders if he will be on the job long enough to save her life which could end up costing him his medical license.
Moments before mobster Joey Arnello is set to reveal his mob secrets in federal court, he ends up collapsing. A court order instructs House to find out if he is faking and quickly. House and his team struggle to diagnose and cure Joey mainly because his brother, Bill, is dead set against Joey testifying at all. In the meantime, Cuddy tries to convince a disbelieving Vogler that House is actually an essential part of the hospital and not just costly as he thinks. Joey keeps mysteriously slipping in and out of a coma and now that his job is on the line, House decides it's time to make an exception to his own policy and tries to get to know his patient.
An obese 10-year-old girl presents with a heart attack. At first thinking it's an adverse reaction to diet pills, they ultimately uncover a much more deadly source of her illness. Also, House is also faced with a woman who will not accept a surgery for a 30 lb. tumor because she actually wants to remain overweight. Meanwhile, House is under orders from Vogler to fire one of his team. He finally makes a decision but Vogler doesn't accept it and demands he pick someone else, it leads House to suspect one of his own team members is giving inside information to Vogler.
After Senator Wright become ill at a fundraiser, Vogler convince House to take Wright's case. To save his whole team, House must deliver a speech on behalf of Vogler's pharmaceutical company, which he does. However, it's certainly not the speech Vogler wanted him to give. Meanwhile, after the Senator's symptoms and tests point to AIDS, a condition which would end his hope of becoming the President, House and the team dig for different answers.
House and his team are trying to find out discover just what is causing brain and kidney dysfunction in a pregnant woman. After House finally diagnoses his the woman's illness, she and her husband must chose whether to save her life or that of their unborn child. Meanwhile, Vogler sets up a board meeting to get rid of House, but when Wilson refuses to make the vote a unanimous one, Vogler lashes out against him and shocks Cuddy and the rest of the board with his decision.
After a meningitis outbreak hits the hospital, House decides to focus on a 12-year-old whose symptoms are similar to the disease. House, Foreman and Chase must devise ingenious ways and locations to treat the girl's delicate condition amid the chaos, even though Cuddy only gives them an hour. In the meantime, House decides to ask Cameron to come back to her job now that Vogler has left. She agrees, but on one surprising condition.
House apparently finds a way to scare one of the clinic patients into having a stroke. Soon the team is trying to find their way through the patient's odd lifestyle, an overbearing "friend" and reluctant parents in order to stop the strokes and try to save the guy's life. Meanwhile, the hospital is abuzz with House's upcoming date with Cameron, so Chase, Cuddy, Foreman and Wilson all try to give him and Cameron advice.
House is surprised when his ex-girlfriend, Stacy Warner, makes a visit. He's even more surprised when he finds out that she's not there to see him, but to get help for her ailing husband. As House debates over whether or not to take the case, Cuddy decides to make him a substitute lecturer to a class of medical students. While there, he weaves together three stories of patients who all have the same symptom. The lecture is one that the students, and all those who hear it, will never forget.
House is convinced that just because Stacy married someone else, he can handle treating her husband. However, when Mark's tests come back normal, House is stumped as to why all the symptoms show that his brain is still dying. Wilson worries about his friend's emotional well-being and the entire team wonders if he can put his feelings for Stacy aside long enough to find out what's really wrong with Mark. Cuddy ends up adding to the dilemma when she ends up offering Stacy a reason to stay.
An inmate on death row starts seeing hallucinations of the people he has murdered. Cuddy reluctantly offers a very excited House the case. Without a respirator the inmate will die within an hour. Stacy pulls some strings and the inmate is brought to the hospital, where House's team of doctors couldn't care less about treating a man who will die anyway. Meanwhile, Cameron is having trouble telling a patient that she has cancer and will soon die.
A young girl who suffers from cancer is about to administer her medicine when she begins hallucinating. An ill House shows up to work and Wilson asks him for help on the case. The doctors learn that the hallucinations are unrelated to the patient's cancer. After numerous tests, the doctors can find nothing wrong with the young girl. However, House believes that the girl's bravery is a symptom of a dangerous disease.
Cuddy's young handyman, Alfredo, ends up falling from her roof and she soon joins the team in figuring out what caused him to fall in the first place. Cuddy is racked with guilt, even more so after House must amputate his hand after it becomes infected, because he is the sole provider for his family. After taking a trip to his neighborhood, the team may figure out just what caused Alfredo's illness in the first place.
After Dr. Sebastian Charles, who is renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to the hospital after collapsing, he immediately determines all the symptoms are from TB. House does not believe it and orders rounds of tests. Soon after the case gets the attention of the media, Dr. Charles refuses any more tests and medication in order to bring to light about the medical needs in Africa. Cameron actually sees eye to eye with Dr. Charles, but House ends up making his situation worse. Meanwhile, Foreman fills in for House in the clinic with mixed results.
A recent Princeton graduate ends up in internal shock while attending a frat party. With his father by his side, it's clear that Carnell is not being too truthful about his life. House soon thinks that his symptoms could be caused by a recent Spring Break trip the young man took. Meanwhile, House is actually having his own issues with his father and keeps trying to get out of a dinner engagement with both his parents who have just arrived for a visit.
After a professional bicyclist is brought in, House refuses to treat him because he is convinced the man is lying about using steroids to help him perform better. Cameron is upset at the fact that the man is actually a hero to little kids and ponders what she should ethically do. Meanwhile, House decides to ruin Stacy and Mark’s relationship by attending a group therapy session with Mark.
A scuffle with House lands a gay man with AIDS in the hospital, where he provides the disagreeable diagnostician with a medical puzzle. The man coughs up blood on Cameron, who begins behaving uncharacteristically. Elsewhere, House finds an unusual way to spend time with Stacy.
Chase misdiagnoses a woman with an ulcer, and flashbacks dissect the case as her condition deteriorates. Stacy questions him and House about it following the patient's death and prior to a hospital disciplinary hearing.
After a gambler collapses in front of House while they’re both betting on horse races, the team soon discovers she’s been seeing a number of doctors for a variety of supposed illnesses. This leads everyone, but a skeptical House, to believe that it is Munchausen’s which is a disease that causes people to fake symptoms for the medical attention. Of course, with Foreman as House's supervisor, it becomes more difficult for him to get things done his way.
After journalist collapses at his editor's retirement party and hits his head, he regains consciousness but his words do not make sense. Since House is in Baltimore trying to defend his Medicaid billings with Stacy, the only way the team can help figure out what's wrong with Fletcher is through the telephone conversations. Meanwhile, as they are stranded at the airport together, House and Stacy realize that they still have feelings for one another.
A young housewife, who happens to be taking some fertility medication, is brought to the hospital when she begins having muscle spasms so bad that she crashes her car. As Margo's symptoms continue to get worse, House and the team think she might have Huntington's Disease but when Margo descends into paranoia, they dig deeper and discover that she might not be telling them the whole truth. Meanwhile, after House and Stacy return from Baltimore with a rekindled relationship, Wilson begins to worry that House is just setting himself up for a hard fall. Also, Cameron is refusing to find out the results of her HIV test.
A young man comes into the hospital severely burned, but the test quickly show that their is something unusual about his blood tests. The team has to get creative to figure out how to test the patient before his body completely shuts down. To make matters worse, House is hellbent on proving that one of his old medical school colleague's new migraine drug does not work no matter what he happens to be saying. So, House decides to make himself the guinea pig for his own batch of tests with some painful results.
House must treat a teenage supermodel for her heroin addiction, but soon realizes there is something different about her. Wilson is wondering if House's increased leg pain means that his leg nerves are actually regenerating. Also, a male patient in the clinic is somehow experiencing his wife's pregnancy, including her labor pains.
After man experiences a seizure but has no idea he has had it arrives at the hospital, House eagerly takes on the case. The team believes he has a bacterial infection, but Henry suffers a heart attack before the treatment for his infection is able to work and now needs a heart transplant. He chooses to approach the husband of the deceased woman, and feigns interest, only because he wants the heart. House and the team have to race against time to find out what the woman died of before they can use her heart for Henry.
Bob comes in suffering from a breathing attack after role-playing with his wife. After trying to find out what's wrong with him, House decides to tell the man he has a sexually transmitted disease, which causes his wife to tell House a secret. Meanwhile, Wilson has moved in with House and things are not going too well for either of them.
Melinda, a rebellious girl, has a severe allergic reaction and ends up going into shock because she is immunocompromised from a heart transplant she had earlier in life. Soon Melinda's condition worsens and she becomes paralyzed, with the paralysis slowly moves up her legs. To make matters worse, her overprotective mother and boyfriend are constantly fighting about her condition. The team must find a way to stop the paralysis and figure out what is wrong with her before it gets to her heart. Meanwhile, House and Wilson are still having problems with their living arrangement.
A 6 year boy is brought into the hospital with symptoms that House is convinced he has seen before in an elderly woman who died. House tries to convince Wilson to keep Cuddy from knowing what he is up to as he becomes frustrated in trying to find a way to cure the boy.
After a patient, Hannah, is brought after taking an overdose of sleeping pills, it is revealed that she previously had not slept in 10 days. As her condition becomes worse, House discovers that she will need a liver transplant. It turns out that the woman's girlfriend, Max, is the perfect match. However, after the team discovers something else about the couple's relationship, it forces them in an ethical quandary. Meanwhile, Cameron accuses Foreman of stealing a medical article she wrote, but he says he wrote one almost exactly like it before hers was even submitted.
House takes the case of Boyd, a 15-year-old faith healer, who thinks he can talk to God. House thinks he's making it up, until he sees Boyd touch one of Wilson's cancer patients and she later goes into remission. After Boyd decides that he will not have brain surgery because he his afraid he will lose communication with God, the entire team must confront their feelings about faith. Meanwhile, Cameron and Foreman are still at odds over the medical article she accused him of stealing.
After a police officer is shot and begins experiencing unexplained giddiness, House sends Dr. Foreman to the man's home to see if he can gather a clue as to why he is acting the way he is. Soon the officer's health begins to decline and Foreman suddenly begins to experience the exact same symptoms as the officer. The team must race against time and solve the man's case before Foreman begins to suffer the exact same fate.
In the conclusion, the police officer has died and Foreman's symptoms continue to get worse. He is now experiencing the same blindness, excruciating pain and muscle contractions that the officer had just before he succumbed to the still unknown disease. As Foreman realizes that he may die, he gets in contact with his father who quickly comes to be at his side. Foreman's condition quickly begins to worsen and the only solution is a brain biopsy. House is determined to find the solution in the dead officer's apartment before Cameron has to do the biopsy on Foreman's brain.
After a young mother has a seizure while bathing her child and almost drowns him, House and the team must discover what is causing Kara's seizures and find a way to save her son's life. Soon, both of their conditions worsen and Kara's husband is forced to make a tough decision, but he soon learns a shocking secret about his wife. Meanwhile, Chase decides he needs a break from the hospital and House wants to know why Cuddy has asked Wilson out on a date.
House's ex-bandmate brings in a 16 year old girl Katrina victim, whom he recently just found out was his daughter, because she has been suffering hallucinations about the catastrophe. House is convinced the girl is trying to scam his friend and must work through the girl's lies to try and figure out what is truly wrong with her. Meanwhile, House is asked by Cuddy to review two medical files and discovers she is looking for a sperm donor.
Just as House and his team are working on the a man with a giant, swollen tongue, a disgruntled former patient Jack Moriarty walks into House's office and shoots him. House decides he must continue to treat Vince from his ICU hospital bed with Moriarty, shot by hospital security and hand-cuffed to his bed, as his roommate. Soon, the aftereffects of the shooting begin to impact House and he starts to question his own ability to properly diagnose. As Vince's body deteriorates, House must struggle through his self-doubt and trust his team to find a way to solve the case.
House is back to work after his gunshot wounds and insists on dealing with two cases which involve paralysis. However, his life-threatening wounds have left House with a new outlook on life that leave his co-workers suspicious of his motives.
House takes on the case of a 7-year old boy who claims to be the subject of alien abduction and experimentation. Meanwhile, Cuddy and Wilson conspire to convince House that his last diagnosis was incorrect in the hope that he might learn some humility.
House and the team take on the case of a medical researcher who is suffering from an unidentified debilitating case that proves life-threatening despite the hospital's best efforts. Meanwhile, House is forced to return to using his cane when the new treatment for his leg proves less than successful.
House sympathizes with a 10-year-old autistic boy who screams loudly for no reason, but his co-workers soon wonder if House empathizes with the boy because he has no social graces either. Meanwhile, House spars with Cuddy over the remodeling of his office, and deals with a teenage crush.
A 20-year-old female patient, Tracy Dawson, arrives at the hospital with with breathing difficulties and intense abdominal pain after a robbery. However, her husband starts displaying the same symptoms and the team suspects the couple's illnesses are related. Meanwhile, antagonizing the wrong patient in the clinic.
An immensely overweight man is brought in after he's found at home in a coma. Upon regaining consciousness, he demands to be released. When Cameron comes up with a way to force him to stay, the man insists the find a reason for his illness other than his obesity. Meanwhile, Det. Tritter arrests House, searches his home, and questions his co-workers about his Vicodin usage.
Gabe, a 10-year coma patient, receives a visit from his son Kyle. When House induces a coma in Kyle, he realizes the boy may be suffering from a genetic condition, and has to turn to Gabe for answers. Meanwhile, Tritter puts pressure on Chase, Cameron, and Foreman to reveal what they know about House's abuse of drugs.
A young man forced to raise his younger siblings has to choose between a necessary medical treatment and keeping his family together. Meanwhile, Tritter goes after Wilson in his quest to bring charges against House.
Divorced parents argue over how to treat their daughter, who seemingly has pancreatitis. House takes them to court on behalf of the hospital to force the treatment he believes she needs. Meanwhile, Tritter continues to try and find something against House, and goes to obsessive lengths to do so.
Wilson betrays House to Tritter in the belief that House will finally gets the help he needs. House refuses, and Cuddy is forced to cut off House's Vicodin supply, leaving him unable to deal with a 15-year-old little person who entered the hospital with a collapsed lung and anemia, and whose condition soon deteriorates.
House must make a tough decision to avoid going to jail, while a firefighter refuses to reveal the secret that may save his life.
House has beaten the drug charges and is back at the hospital after a short stint in rehab. Cuddy comes to collect on House's debt for perjuring herself on the stand and keeping him out of jail. She forces House to pay off the debt in clinic hours, requiring him to carry out a series of less-than-desirable patient exams in the clinic. Tired of House's incessant whining about his disdain for the patients, Cuddy turns his clinic duty into a game, with the stakes raised to a level that speaks to House: money. At the clinic, House encounters patient Eve, who has tested positive for an STD and admits she's very recently been raped. Knowing he can't do anything more for Eve medically, House refers her to a psychiatrist, but she refuses to talk to the doctor and will only be treated by House. He repeatedly tries to dismiss himself from her case, but finds himself forced to unravel a very different puzzle than the sort he's used to and is compelled to come to terms with events in his own life in order to help Eve make sense of her own. Meanwhile, at the clinic Cameron encounters a homeless man with terminal cancer who, in spite of her pleas to let her ease his suffering, admits to her his basis for refusing pain medication during his final hours.
16-year-old Stevie Lipa is admitted to Princeton Plainsboro Teaching Hospital with a serious respiratory condition and internal bleeding. Oddities of his case land him under House and the team's care, but at the moment, House is irritated to learn that new hospital researcher Dr. Julie Whitmer has been assigned his handicapped parking spot by the hospital entrance. Since she's in a motorized wheelchair (and he has to walk), he asks her to give up the parking spot, but she refuses. House, determined to get a parking spot closer to the hospital entrance, appeals to Cuddy, who dares him to prove how much he wants the spot by spending one week in a wheelchair, a bet House takes on. As the team tries to get personal history information from Stevie, they can't seem to get a straight answer out of him, and it's revealed he's from a family of gypsies. Stevie's parents arrive with homeopathic remedies; they won't consent to House and the team's suggested course of action, and refuse all modern medical treatment. As Stevie's body continues to bleed internally, Foreman makes the risky decision to sidestep Stevie's parents and appeals directly to the teenage patient, putting his medical license on the line while asking Stevie to lie to his parents.
Its Valentines Day at Princeton-Plainsboro and the ER is short-staffed due to a snowstorm. House encounters Foremans latest patient, Hannah, who has sustained injuries from a car accident with her mother, Abby. House notices that despite her best efforts to act injured, Hannah is not feeling a bit of pain. House determines that Hannah has an incredibly rare condition that makes her completely insensitive to pain, and he takes a special interest in her case. He orders further testing to see if Hannah has any serious injuries from the car accident that she may not be able to feel, including an unnecessary procedure that causes Cuddy and Wilson to question his motives. Meanwhile, Abby undergoes surgery for her own injuries sustained in the car accident. Hannah refuses further examination and demands to see her mother, but House has little sympathy. She and House argue about which of their lives is worse, Hannah who is impervious to pain or House who suffers from pain constantly. When Hannah passes out and her temperature spikes, the doctors realize that Hannah is much sicker than they had thought. The team takes drastic measures in an attempt to inflict pain on Hannah to measure her pain threshold, but her condition only worsens. House adamantly pushes for a spinal nerve biopsy that could leave her paralyzed, a risky procedure in which few see the benefit, especially Cuddy and Wilson, who accuse House of pushing the test to get information that may benefit his own pain management. As Hannahs body deteriorates without her so much as flinching, House works through his own chronic pain to find out why this young woman cannot feel any pain at all.
Patrick Obyedkov, a 35-year-old musical savant, is in the middle of playing a piano concert when he suffers a painful involuntary muscle contraction in his left hand. After Patrick is admitted to Princeton-Plainsboro Hospital with a rare movement disorder, his case attracts the attention of Dr. House. House learns from Patrick’s father, Dr. Obyedkov, that Patrick suffered severe brain damage at age 10 from a bus accident that also killed his mother. House is intrigued as to why Patrick, who was a healthy 10-year-old at the time of his accident with no prior musical training, could. suddenly play the piano flawlessly after suffering a severe injury. He pushes for further testing on Patrick’s brain even though the team has diagnosed him with a simple muscle-contraction problem. While trying to deduce the origin of the brain rewiring responsible for Patrick’s mysterious gift of music, House and his team must stop the deadly bleeding that is quickly threatening his life. Patrick’s condition worsens as he suffers an onset of seizures, and as the team attempts to stabilize him, House presents a very difficult option to Patrick’s father – a neurological procedure that would change Patrick’s life forever. In the meantime, Cameron discovers that House has been in contact with a hospital in Massachusetts and suspects that House may be looking to take a new job there. When Cuddy contacts the hospital, she learns that House has been in contact with a brain cancer specialist – not as a job applicant, but as a patient for a clinical trial. When confronted by his team, House denies the gravity of the situation and resents their interference, and they are forced to contend with the possibility his condition may be more serious than he’s letting on.
House is bewildered yet intrigued when he meets his newest patient, John Kelley, an ex-Marine who had saved Houses life in a very realistic dream the night before. House is puzzled about how this man could have appeared in his dream before he met him.
Recently returned from a two-year deployment in Iraq, Kelley is complaining of fatigue, pain and other non-specific ailments he thinks are the result of Gulf War Syndrome. Just like the V.A. doctors before them, the team is wary about the validity of Kelleys symptoms, but since his uncle is an important benefactor to the hospital, they continue to investigate his case.
Meanwhile, House is suffering from ailments of his own he is unable to urinate, most likely a side effect of his Vicodin abuse, and is sleep-deprived. Unable to concentrated on the case, he eventually turns to Wilson for an under-the-table prescription.
While administering tests in the sleep lab, Cameron and Chase forego their clinical duties when they find each other (and a bed in the sleep lab) much more exciting. A foul infection shows up in Kelleys mouth while Cameron and Chase were supposed to have been on the clock, and his condition only worsens as he begins to lose his hearing, sight and mobility.
A brain scan reveals tumors in Kellys brain that were not there a week earlier when the government doctors at the V.A. examined him. When traces of uranium show up in Kelleys test results, the teams wonders if the government had something to hide,
A famous, 42-year-old, pregnant photographer, Emma Sloan, is brought to the hospital after suffering a stroke in the middle of a high-profile photo shoot with Tyson Ritter. Although Emma's condition initially stabilizes, her health takes a turn for the worse when her kidneys inexplicably fail. As her health continues to deteriorate, Emma is more concerned about her baby's well-being than her own.
With no other viable explanation for the kidney failure, House realizes Emma may have a rare condition called Maternal Mirror Syndrome, in which the mothers health mimics the distress level of her fetus.
Meanwhile, Cameron and Chases secret relationship is exposed to Foreman and Cuddy, and House makes extravagant plans to take a much-needed vacation.
House calls Cuddy on the fact shes taken a special interest in the case as she identifies with Emma's struggle to have a child later in life, but her compassion for Emma may be clouding her judgment in the case. When Emma's liver begins to fail, House presents her with the heart-wrenching choice to terminate her fetus or die herself. But with Cuddy on her side, Emma demands they come up with another option an option that may not exist. With Cuddy and House at odds over how to handle her case, Emma faces a life-and-death situation for both herself and her unborn child.
House and Cuddy board a flight back to the United States from Singapore, where they were speakers at an international conference. Shortly after takeoff, a passenger seated next to House becomes violently ill. While House brushes it off as a hangover, Cuddy suspects the man might have a deadly contagious virus and the other passengers could be at risk. Assuming the worst, Cuddy suggests the plane turn back and land, but House dissuades the flight attendant and the flight continues on. As the man's condition worsens, the rest of the passengers on the flight become increasingly uneasy, and so does House when a second passenger falls ill with the exact same rash and debilitating symptoms.
Back at Princeton-Plainsboro, Wilson leads the team when they encounter Fran, a middle-aged woman who collapsed at her home and soon goes into seizures. Cameron and Chase investigate Fran's house to look for clues to a diagnosis, but they are distracted by the prospect of an empty house and an inviting bed. When they return empty-handed and Fran's health continues to decline, the team must focus on finding out what is killing Fran without House's help. Back on the flight, with First Class turned into a makeshift isolation area, House calls upon a misfit team of passengers to fill in for his own team, as he bounces questions and theories off of them. When Cuddy collapses and several more passengers fall ill, the situation turns dire as the plane is hours away from any viable landing place. Without the help of his team or even proper medical equipment, House finds himself with Cuddys life and a plane-full of passengers lives in his hands.
The team takes on the case of 6-year-old Lucy, who collapsed at daycare. They discover that the tissues surrounding Lucy's heart have hardened and are strangling her heart, a condition usually found in much older patients. As the team searches for an explanation, Lucy's condition worsens and she suffers a stroke.
There's a palpable tension between Cameron and Chase, and House intentionally assigns them tasks to do together, including a trip to Lucy's house to check for any possible environmental explanations for her condition. While there, they discover surprising evidence indicating that Lucy may have been abused.
Lucy's 8-year-old brother develops a not-so-innocent crush on Cameron, and as he becomes increasingly aggressive, House suspects that whatever is killing Lucy has begun to affect her brother, too. As they try to narrow down what is causing Lucy's condition before its too late, House and Cameron clash over how to treat her.
Meanwhile, when Wilson takes Cuddy out to see a play, House puts ideas in Wilson's head regarding Cuddy's motivation for going with him.
The team takes on the case of Lupe, a young female scam artist who passes out while working a card-playing scheme on the streets. Lupe suffers from a lack of blood to the brain which had temporarily paralyzed her ability to make decisions or exercise free will. Measuring from her background, Foreman immediately suspects Lupe's condition stems from drug abuse, while Chase looks for other possibilities, such as toxins, in Lupe's apartment.
Lupe senses Foreman's disdain for the decisions she's made in her life, and Foreman grapples with his own humble past when his parents come to visit him. When Lupe's symptoms worsen and her organs begin to shut down, Foreman and the team suspect cancer to be the culprit.
Meanwhile, Cuddy and Wilson go out on a date to see an art exhibit together, and House probes Wilson's ex-wife about Wilson and his dating habits.
When the team learns some devastating news about Lupe's condition, they realize that their own decisions, rather that Lupe's, may cost Lupe her life.
Wilson prepares his 14-year-old leukemia patient, Nick, for a last-resort bone marrow transplant from his younger brother, Matty. With Nick's immune system completely wiped out from chemotherapy, Wilson is extremely cautious about keeping him healthy before the transplant. However, when Matty sneezes during a pre-op visit to his brother, Wilson knows that Matty is not healthy enough to donate. House and the team race to find out what is making Matty sick so that they can treat him quickly and allow him to donate healthy, uninfected bone marrow to his dying brother. With no other matching donors available, the team knows that Matty is their best shot at saving Nick's life, since giving Nick bone marrow from a partial-match donor could lead to an excruciating death if Nick's body rejected it. House decides they must purposefully make Matty sicker and use his developing symptoms as a method of narrowing the diagnosis field. As both brothers' conditions worsen and Nick has only days to live, the team must diagnose and treat Matty before it's too late for both brothers.
Meanwhile, Foreman is haunted by his mistake that killed a patient just one week earlier, and House only wishes he could incur similar misfortune upon his new pet and nemesis, Hector.
Addie, a 19-year-old college student, is admitted to Princeton Plainsboro after coughing up a mouthful of blood during karate class. Before treating the patient, Foreman unapologetically informs the rest of the team that he is resigning, but will not say why.
House strongly believes an infection is to blame for Addie's bleeding, even though her symptoms indicate otherwise. When Addie's lungs suddenly fill with fluid, the team believes that cancer or toxins could be an underlying cause, but House refuses to stray from his initial infection diagnosis. As Addie's condition worsens, House suggests a risky life-or-death treatment to confirm his suspected diagnosis, leaving the team wondering whether he cares more about making a diagnosis than he does about saving Addie's life.
Meanwhile, House takes a special interest in a young, attractive nutritionist named Honey, who accompanied her boyfriend to the clinic for treatment. Knowing he will have a position open soon on his team, House has Honey fill out an employment application and sees to it they meet again under more casual circumstances.
Obnoxious 16-year-old chess prodigy Nate is admitted to Princeton-Plainsboro suffering from intense head pain that came on after he attacked his opponent during a speed chess tournament. Nate's mother tells the team that Nate has been having behavior problems ever since he became a teenager, and House suspects the behavior is a symptom of cluster headaches. As House's team carries out further testing to see why he might be having the headaches, Nate manages to offend and annoy each doctor on the team. As Nate's illness progresses, his liver and kidneys begin to fail. To narrow down the list of possible diagnoses, House carries out a series of unconventional and eccentric tests of his own, including engaging Nate in a game of chess to try to beat him at his own game. Meanwhile, Foreman's frustration with House reaches a new level when he believes House sabotaged his job interview with another hospital, and Cuddy makes Foreman an offer she's sure he can't refuse.
A Cuban couple flee to America to find Dr. Gregory House, as the wife is suffering from undiagnosed illness. However, when they finally get there they find that House can do little for them. Meanwhile, the staff deal with Foreman's departure, which heralds the first of several radical changes in the staff.
An office building collapses and House must race against the clock to diagnose Megan, a young woman who survived the disaster but can only communicate through blinking. However, House is without a team after Foreman and Cameron quit and the firing of Chase, so he's forced to talk through his ideas with the hospital janitor. But when Megan's condition worsens, House is pressured to hire a new team. Though reluctant to do so, House begins to realize diagnosing patients by himself is not as easy as he thought.
House reluctantly agrees to interview potential new team members and does so in his own way. He calls in all 40 applicants and places each of them in a Darwinian trial period. As he tests them, and fires some along the way, he is approached by Greta, a NASA training program candidate, who is having neurological issues and begs House to help her in private so she can be accepted into the training program.
House takes Greta's case to his applicants, pitting them against one another as they compete to come up with an accurate diagnosis. Later, House is shocked when he sees what appears to be Cameron, Chase and Foreman in the hospital hallways.
The final 10 candidates are put to the test when House splits them into gender groups. Each team is assigned to accurately diagnose and treat a man with muscular atrophy who is slowly suffocating. Complications arise when one team treats the patient, but doesn't make sure their treatment was executed.
Meanwhile, as the teams work, House conducts experiments on himself to see how it feels and what occurs in the moments when a person is in between life and death.
The team treats a patient who not only claims to see the dead, but she communicates with them and knows things about them she normally couldn't find out.
The team takes on the case of a man who collapsed while being mugged. When the man complains of new symptoms that do not fit his initial admission profile, the team suspects he is a hypochondriac. As Mr. X continues to fall ill with symptoms unrelated to his neurological disorder, Foreman and the remaining six fellows are assigned to keep watch, and are bemused as they see their own behavioral idiosyncrasies reflected through him. As they attempt to diagnose this human chameleon, they seem to learn more about themselves than their patient, whose true identity is a mystery. Meanwhile, Cameron and Chase keep a running pool on whom House might cut next from the team of candidates, and Foreman engages in a power struggle with House and Cuddy.
House is recruited by the CIA to help diagnose a deathly ill agent with an unknown illness. The agent's medical case is being spearheaded by Dr. Samira Terzi, who offers up very little information about the agent's history or previous assignments. With limited information to go on, House uses some unorthodox methods to try to crack the code and determine a diagnosis in time to save his mystery patient's life. Meanwhile, Foreman faces resistance from the remaining six fellowship candidates when they question his judgment and argue over the diagnosis of a female drag car racer who passed out after a race
A documentary film crew is chronicling a teenager with a major facial deformity who opts to undergo a dramatic reconstructive procedure. When the patient suffers a heart attack just prior to the surgery, House and the team are called in to determine the cause, since the surgery cannot proceed until the patient's cardiac condition is diagnosed. With the film crew covering their every move, Cameron and Chase are especially self-conscious, and House looks for ways to escape from the cameras. Meanwhile, House finds himself distracted by several of the candidates vying for a spot on his team, and he questions his motives for having chosen them.
House treats a magician who had a heart attack during an illusion. House doesn't like magicians and figures the guy screwed up, but the tests prove otherwise. Meanwhile, the fellows participate in House's newest game: the winner gets immunity and the chance to pick two other fellows, and House will fire one of them.
When Cuddy puts the pressure on House to choose the final members of his team, House deliberately assigns the candidates to a particularly challenging case an uncooperative, over-the-hill former punk rock star with a history of drug abuse and civil disobedience. House informs the candidates their potential future depends on correctly diagnosing the patient. As the candidates race to find out if the patient is ailing due to drug abuse, an underlying disease or an unknown condition, House keeps a running tally of their efforts, making a few arbitrary point deductions along the way. Meanwhile, Wilson informs a former patient whom he had previously diagnosed with terminal cancer that he is going to live, and the news throws a wrench in the man's carpe-diem lifestyle
A mother's hands are paralyzed during an indoor rock-wall climbing incident, causing her daughter to injure herself. At the hospital, her condition worsens and House and his newly-assembled team race to find a cure. Meanwhile, House decides to add a few twists to the season's Secret Santa gift exchange.
House and his team must diagnose an ailing researcher by webcam, as she's iced in at an Antarctic research base with a limited amount of resources. Meanwhile, House is determined to find out who it is that Wilson is now dating.
A bride collapses during her Hasidic Jewish wedding, but her husband isn't convinced by House's bedside manner. House is occupied dealing with the shock brought on when he discovers who Wilson's new girlfriend is.
House is intrigued by a patient who is nice... constantly. Believing he's suffering from some illness, House orders a series of tests. Meanwhile, Amber and House haggle over spending time with Wilson, the team discover a shocking secret about their boss, and Cuddy tries to get House to complete his performance reviews.
After observing one of the actors from his favorite soap opera "Prescription Passion" showing symptoms of a serious medical condition while on TV, he decides to take matters into his own hands. But both the actor and House's own team believe there is nothing wrong with him and dismiss Dr. House's assessment.
A bus accident has left House with a head injury along with dozens of passenger with injuries. Although he is dazed, House has flashbacks where he can recall one passenger having had the signs of a deadly illness, but can't remember who it was or what he saw that clued him in.
House is still suffering from injuries resulting from the bus crash, and struggles through his amnesia to recall a key symptom that he saw an associate suffering from, before it's too late.
After Wilson threatens to resign, House thinks of anything to try and keep him at the hospital, and to keep their friendship alive. Meanwhile, the team treat an executive assistant with a Class A personality who reminds Thirteen of herself.
The team deals with an organ donors whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.
House and his team diagnose a struggling artist dying of an unknown disease, whose illness affects not only his career and his relationship, but his work.
House's friends and teammates coerce him going into his father's funeral. However, en route they get the case of a young Chinese girl and House must participate in the differential by phone... until he's unable to take a call at a critical moment.
Thirteen's female lover has a seizure after a night of partying and she takes the woman to the hospital. It turns out the woman has a long-standing medical condition and slept with Thirteen to get House to see her. Meanwhile, Foreman confronts Thirteen about her destructive lifestyle and House continues to have Lucas spy on Wilson.
A middle-aged man finds himself suffering from blackouts and sleepwalking, and is admitted to the hospital. As his condition deteriorates, his daughter needs to transplant a kidney. Meanwhile, Cuddy prepares to adopt a baby but the mother's prior drug use damages the baby's lungs, forcing Cuddy to choose between delivering the baby early and endangering the child, or waiting and putting the birth mother's life at risk.
Due to her previous experience, Cameron works with the team to treat a agoraphobic man who refuses to leave his home. As the man's condition worsens and they have to figure a way to operate at home or relocate him to the hospital, House suffers from a maddening itch he can't identify. Meanwhile, Chase and Cameron deal with an issue in their relationship.
An emancipated 16-year-old factory worker falls ill to the point of near unexplained death. Meanwhile, Foreman tries to handle his own caseload and the diagnosis of a child without House's oversight.
A man seeking the right diagnosis for his illness is willing to take on the hospital and the SWAT team to get it. He takes Thirteen, a nurse, and several patients from the waiting room and puts them in Cuddy's office. To put an end to the crisis they must come up with the right diagnosis, treat the wounded, and hold off a SWAT team.
House and the team try to help a fitness guru who collapsed during an infomercial filming. Foreman conducts drug trials for Huntington's and Thirteen participates: Cuddy moves into House's office while her's is repaired, and Kutner runs an Internet advice clinic using House's name.
House and the team diagnose a bullied girl who collapses at her school's holiday pageant. Meanwhile, House gives one of his patients a gift, Cuddy gets a gift, the team tries to figure out who gave House a special gift, and Foreman learns a lesson from Thirteen during the Huntington's drug trials.
House and the team diagnose a suicidal man suffering from chronic pain. Meanwhile, Cuddy discovers that her new baby takes up more time then she anticipated, and Foreman and Hadley deal with their relationship.
House suspects a Special Education teacher of becoming ill from her inherent goodness. Meanwhile, Cameron takes on some of Cuddy's duties and finds herself up against House. And Foreman has to make a decision when he learns that Thirteen is receiving the placebo in the Huntington's clinical trials.
The team take on the case of a cancer researcher who gave up her career to pursue personal happiness. While House's staff question how much happiness they've found, Cuddy metes out some poetic justice to House, and Thirteen begins suffering reactions to the Huntington's trials.
A priest sees a bleeding Jesus on his doorstep and House insists on taking the case to poke fun at the man's religion. However, when the priest displays more symptoms, the case becomes serious as he takes a turn fro the worse. Meanwhile, House gives Thirteen and Foreman an ultimatum, and Cuddy invites the staff to her baby's christening.
Jackson, a boy born with genetic mosiacism, collapses during a basketball game. His parents don't want the doctor to tell their son that Jackson has both male and female genes, even if that is the source of his illness. Meanwhile, Thirteen and Foreman try to hide their relationship so House won't fire them, and House is in a surprisingly good mood.
The team takes on the case of a book editor who suffers from frontal-lobe disinhibition, causing him to uncontrollably speak his mind. Meanwhile, Wilson finds his long-lost mentally ill brother and recruits Taub to cover for him so House doesn't find out.
Morgan, a nursing-home nurse, fake an illness to get House to see her. She believes that a "death cat" at the nursing home can predict who will die next... and the cat has settled on her. Meanwhile, Taub considers an investment opportunity.
House is injured in a motorcycle accident in New York, but he's more interested in the case of Lee, a man who had a bicycle accident and now appears brain-dead. House quickly determines that Lee can still think and has him transferred to Princeton to find a cure. Meanwhile, Wilson is intrigued by why House was in New York in the first place.
Charlotte is tending to her dying husband Eddie when she goes into respiratory distress. At the hospital, Eddie seems to recover while Charlotte gets worse. However, the team's attention is divided when an unexpected tragedy strikes the members from within.
When Cameron learns of an environmentalist who collapsed during a protest, she postpones her vacation with Chase to refer the case to House and stays on to make sure her former boss follows through. Chase begins to wonder if Cameron is in love with House. Meanwhile, Wilson goes on a mysterious health diet, piquing House's interest.
A deaf 14-year-old wrestler collapses during a wrestling match while hearing imaginary "explosions." However, House is distracted by his lack of sleep, hallucinations of a familiar face, and his preparations for Chase's bachelor party.
When a ballerina's lungs collapse during a performance, she's brought to the hospital where the team soon discovers that her skin is coming off. House is distracted by his hallucinations of Amber and the realization of the only way to stop them. Meanwhile, Cameron asks Chase for a special pre-nupitial gift.
A patient, Scott, has a rebellious left hand when the left and right sides of his brains start acting independently. Meanwhile, House deals with the aftermath of his one-night stand with Cuddy.
House undergoes treatment for his hallucinations at Mayfield Psychiatric Hospital, and quickly declares himself cured and ready to leave. The doctor in charge, Darryl Nolan, disagrees and forces House to stay by threatening not to recertify his license until he believes House is cured. A battle of wills begins until House draws closer to the sister-in-law of a catatonic patient, endangers another patient, and admits that he actually does need help.
House resigns his position as chief diagnostician at Princeton, much to the surprise of his co-workers. Foreman immediately leaps in to take command and is given one chance to prove himself. However, his first case is a videogame magnate suffering from burning hands and swollen lymph nodes, and insists on consulting the Internet for medical solutions. Meanwhile, Thirteen tries to reconcile herself with this new side of her boyfriend, Taub looks for employment elsewhere, and Wilson discovers that his new roommate is obsessed with cooking.
When a brutal dictator visiting the U.S. falls ill, the government brings him to Princeton. Foreman is forced to bring in Cameron and Chase to help with the differential, and House returns to announce he wants his job back. Foreman tries to deal with House, and Cameron and Chase try to deal with the repercussions of their decision to try and heal the dictator. Meanwhile, Wilson tries to deal with an obnoxious neighbor who has taken an instant dislike to House.
When an oil executive's son suffers inexplicable symptoms, the man brings him to Princeton and insists that House treat him. House continues to take an advisory role while Foreman leads the team. Meanwhile, Foreman Chase try to cover up the events leading to President Dibala's death, and Hadley tries to figure out who wants to keep her at the hospital.
Cameron takes on the case of a reckless police detective who believes he will die at age 40 because of a family history of sudden heart failure that killed his father, grandfather and great-grandfather at the same age. The team takes on the case despite House's insistence it is coincidence. Meanwhile,Chase is haunted by his actions in the Dibala case, and House hears voices.
A teenager is admitted due to swollen joints but soon suffers from bleeding of the liver. It soon turns out that she is unable to tell the truth due to blood leakage into her thalamus. While Foreman, Cameron, and Chase try to solve the case, House attends a medical conference with Wilson and Cuddy and tries to start a relationship with his superior.
House gets his license and his position back and insists on taking the case of Hank Hardwick, a porn star stricken with photo-sensitivity. When Cameron and Chase announce that they're leaving, House schemes to convince them to stay and bring back Taub and Thirteen as well.
An accomplished physics prodigy, James Sidas, suffering from burnout, is stricken by an unknown disease while working as a courier. House realizes that the physicist has turned his back on his own intelligence. Meanwhile, Cuddy navigates around House's attempted interference in her relationship with Lucas, Chase deals with the aftermath of his marriage's breakup, and Taub takes steps to prevent the destruction of his marriage.
When Wilson's friend and former leukemia patient Tucker suffers paralysis of the arm, Wilson initially insists it's something other than cancer. House disagrees and offers a wager. However, when Wilson discovers what Tucker's illness really is, he has to decide whether to make a personal sacrifice to help Tucker live. Meanwhile, Cuddy tries to buy a house for herself and Lucas.
A drug dealer collapses in the middle of a sale, and his partner takes him to the hospital clinic for treatment. House soon realizes what they do for a living, and Mickey collapses again. The patient refuses to give up any information about his past, and House is determined to get at the truth. Meanwhile, Foreman learns that his teammates are all making more money and tries to negotiate with Cuddy. And House and Wilson vie for the affections of an attractive neighbor, only to discover that she believes they're homosexuals living together.
House and his team take on the case of an ailing businesswoman, Valerie, who suffers from ear pains. As her condition worsens, the doctors realize that Valerie is a clinical psychopath. However, they're not sure if it's a symptom or a psychological condition... and time is running out.
When a college football player goes berserk on the field, the team try to diagnose but he continues to get worse despite their best efforts. Meanwhile, House hires Foreman's brother, a recently-released convict, to get a rise out of Foreman. And House and Wilson engage in a war of pranks.
Dr. Lisa Cuddy has to deal with an ailing daughter, insurance negotiations, a nervous board of directors, a thieving pharmaceutical aide, warring surgeons, and... House, in what proves to be anything but a typical day at the hospital.
A blogger comes down with bruising and bleeding from the gums, and insists on posting her ailments on the illness despite her boyfriend's wishes. As he tries to solve the case, House discovers a dark secret from Wilson's past and can't resist telling everyone. Wilson seeks revenge and learns a secret about House. Meanwhile, Chase worries that he might be too good-looking.
House and the team try to diagnose a high school girl suffering from a rapidly escalating series of symptoms. Meanwhile, Taub tries to demonstrate to his wife that she can trust him after his philandering, and House dares Wilson to decorate the condo by himself.
When a newborn is abducted, Princeton goes into lockdown, and the staff find themselves trapped together. House deals with a dying patient, Taub and Foreman check the personnel records, Cameron asks Chase to sign their divorce papers, and Wilson and Thirteen play Truth or Dare.
When a medieval reenactment knight, Sir William, collapses during a battle, the team takes on the case and Thirteen is intrigued by William's insistence on honor above all else. Meanwhile, House discovers that Wilson is dating his first ex-wife, the "soul-sucking harpy," and vows to break them up to protect Wilson from himself.
Julia and Tom have a happy--and open--marriage. However, when Julia is stricken with abdominal pains, and her condition gets worse, House and his team must find out if honesty is all that it's cracked up to be, and if the happy honest couple actually have a honest marriage. Meanwhile, Wilson and Sam have an argument, and Rachel Taub wonders if her husband wants an open marriage.
When a groom collapses at the altar, the team discover that he harbors a secret that will affect their diagnosis. Meanwhile, Wilson pays House's team to take him out, and Taub tries to have an affair despite House's interference.
House meets with Dr. Nolan, who is intrigued when House insists on describing the case of an amnesiac woman suffering from what appears to be a quick-spreading prion infection. It soon becomes clear that House has more on his mind than just his patient's health.
House reluctantly accompanies Cuddy and emergency teams to the site of a crane accident. However, he's more interested in diagnosing the crane operator back at the hospital than dealing with the injured victims... until a trapped victim must decide whether to allow her leg to be amputated to save her life.
After they declare their love for each other, House and Cuddy decide to spend a day in House's apartment examining their new relationship. Meanwhile, Princeton's status as a Level 1 Trauma Center is threatened when their only remaining neurosurgeon is taken ill, and the team try to diagnose him while wondering where House is.
A young girl who lives her life for her brother, a victim of muscular dystrophy, suffers from heart arrhythmia and is taken to Princeton. House attempts to diagnose the girl but ends up second-guessing himself when Cuddy disagrees with him. Meanwhile, an elderly father and son come to the clinic, each with a hidden agenda concerning the other.
A children's novelist tries to kill herself, but is thwarted when she has a seizure. House, a fan of the books, puts her on psych hold but has to deal with a patient that is eager to die rather than be cured. Meanwhile, House worries that he'll lose Cuddy because they have nothing in common.
The team's newest patient is a wife who suffers from vomiting and stomach pains. While they attempt to diagnose her case, Chase brings in a new female, a psych major who House and Foreman both take offense with. Meanwhile, when Cuddy discovers that House is still seeing his massage therapist and former hooker, she refuses to sleep with him until he loses the woman.
A newborn baby, Kayla, suffers from liver failure and the team discovers that her mother Abbey's blood provides a temporary cure. While they try to identify the underlying cause, House and Wilson end up babysitting Cuddy's daughter, Rachel, and realize that parenthood isn't all it's cracked p to be.
Cuddy forces House to hire a med school prodigy as his new team member to replace Hadley, but House insists on making things difficult. The newcomer's first case involves a political consultant who has liver failure and a rash, and whose condition steadily worsens. With time running out, House realizes that the consultant's illness is tied to his employer, a senator running for re-election.
A young girl on a dive brings up a jar from a sunken slave ship and breaks it, infecting herself with what appears to be smallpox. When House and his team confirm her illness, they call in the CDC, which puts the hospital under quarantine. However, House soon realizes that the girl has something else... but the only way to confirm his diagnosis is to expose himself to the disease. Meanwhile, Wilson and his ex-wife Sam try to tend to a young girl awaiting chemotherapy whose mother is trapped outside by the quarantine.
A religious patient is admitted to the hospital after vomiting blood, after undergoing a crucifixion which he believes keeps his daughter alive. Meanwhile, Wilson proposes to Sam, Taub believes his wife is cheating on him, Masters gets a lesson on the consequences of her honesty, and House tries to prove that Cuddy is a liar.
A subway hero collapses after saving a woman, and is brought to the hospital. House dismisses heroism as stupidity, but is unable to determine the man's illness. Meanwhile, Cuddy's mother comes to see her daughter and her new boyfriend, and Taub discovers that a new billboard with his face has aroused his wife's libido.
A drill instructor at a disciplinary camp is stricken with back and bladder pains. The team try to diagnose his condition and suspect that one of his charges poisoned him. However, they soon discover that the student is showing the same symptoms... and the two patients share a hidden connection.
When Cuddy's mother Arlene is admitted to the hospital complaining of heart arrhythmia, House refuses to treat her, warning Cuddy that it won't end well. Cuddy insists, and House soon antagonizes Arlene so that she fires him. He continues to proscribe progressively more dangerous treatments behind the attending physician's back, putting Arlene's life at risk. Meanwhile, Taub is forced to take a part-time job with his brother-in-law and suffers a crisis of conscience.
A waitress with perfect memory suffers from paralysis of the legs and heart arrythmia, and is admitted to the hospital. House suspects that her memory is a symptom and tries to pin down the cause. Meanwhile, Foreman is forced to tutor Taub when it looks like the latter will fail his re-certification, and Wilson gets a new roommate.
To get Rachel Cuddy into an exclusive preschool, House volunteers to talk at Career Day. While telling the story of a patient who has coughed up his lung, House pretends to be someone else to avoid liability in a car accident, but things go wrong and he's soon in the principal's office. Intrigued by his exploits, two students get House to tell them the whole story.
A former real estate agent loses his job in the recession and conceals it from his wife, secretly taking a job as a janitor to make ends meet. He suffers from a high fever and swollen joints, and the team tries to determine which job caused his symptoms. Meanwhile, House tries to make a charity gala in Cuddy's honor "fun," Masters and Chase argue over honesty with one's spouse, and Taub and Foreman adjust to being roommates.
While a teenage boy spits up blood for no apparent cause, House chooses to focus on Cuddy, who has a mass on her kidney. Unable to bring himself to see her, House dodges his personal and professional responsibilities. Meanwhile, Taub realizes that the boy is suffering from depression and must decide what to do when he discovers the teenager has considered violence against himself and others.
A champion bull rider is attacked by a bull, but when he's taken to the hospital, it's clear that there is a deeper underlying medical problem. The team tries to diagnose without House's presence, since he's gone to a hotel to get over his breakup with Cuddy by hiring a parade of hookers. As the patient's symptoms grow worse, the team wonders if House's judgment is impaired as he proposes progressively more dangerous diagnostic techniques.
A 23-year-old homeless man is admitted to the hospital with a skewed sense of smell, which soon turns into gastrointestinal bleeding. The man refuses to tell the team anything, making it difficult to diagnose him. Meanwhile, in the aftermath of his breakup with Cuddy, House decides to marry a much younger woman to help her get a green card... or so he claims.
House goes to greet Hadley as she gets out of prison after six months, and find out why she was really in prison. Hadley has no interest in talking, and a battle of wills ensue as they go to a spud gun competition. Meanwhile, the team takes on the case of a science teacher with lungs full of blood and a home filled with junk, and discover a secret about the man. While they work on the case without House, Taub renews a sexual relationship with an old acquaintance.
A 16-year-old girl preparing to sail around the world collapses without explanation. Masters, preparing to graduate and become an intern, bonds with the girl and is forced to make an ethical decision when the girl refuses treatment that could save her life, but prevent her from setting a record. Meanwhile, House and Wilson play chicken.
The team treats a lottery winner who suffers from paralysis of the legs, and soon discover that he has cancer... and then he doesn't. Meanwhile, Foreman and Chase make a mutual wager, and Cuddy's mother sues the hospital for her treatment at House's hands.
The team takes on the case of a missile design expert suffering from a wide variety of symptoms. She fails to show improvement and the team looks to House, only to discover that he's obsessed with the case of a boxer who collapsed during a fight.
Hadley's prison cellmate comes to her for help when she receives a knife wound. However, her condition soon grows worse and Hadley calls in Chase for help. Meanwhile, House takes extreme measures to remove the tumors growing in his leg, while Taub receives news from his girlfriend and takes it poorly.
The team treats an esteemed performance artist, but discover that she wants to perform a new piece using House as her unwilling assistant. Meanwhile, House vows to change, but when Cuddy and Wilson insist that he talk out his feelings, he takes a radical approach to making a new life for himself.
A retrospective on eight years of House.
House has spent a year in prison after crushing through Cuddy's living room window. Now to win his parole, House has to behave for just five more days. However, an ailing prisoner pits House and his diagnosis against the hospital doctor, and his only ally is a young doctor who believes there's more to why he's in prison then he'll tell her.
House returns to Princeton Plainsboro on parole to provide his expertise on a unique case: a pair of donor lungs that are suffering a mysterious ailment. However, House soon finds himself hobbled when he learns that his old team has been let go, Wilson bears him a grudge, his new team member has personal problems, and if he crosses the new Dean of Medicine then he'll be sent back to prison.
Benjamin, a wealthy man intent on giving away his money to charitable causes, collapses on the street. House doesn't believe there's anything seriously wrong with him, but treats him so that he can convince Benjamin that he's "cured" and to donate money to fund House's diagnostic team. However, when Benjamin starts showing serious symptoms, House realizes that he has a real illness on his hands. Meanwhile, Thirteen must decide whether to return to the hospital or go to Greece with her girlfriend, and new volunteer team member Dr. Adams tries to determine why Park won't take a gift.
House takes on the case of Thad Barton, a CEO relocating his employees to China who is suffering from vision problems. As Thad gets progressively worse, House engages in insider training with the company's stock so he can finance his department and bring Chase and Taub back. Meanwhile, Park makes the mistake of betting House that she won't get fired at her disciplinary hearing, and Adams has anger issues that puzzle and intrigue House.
A well-respected community leader has a heart attack while secretly having an affair. However, when his condition worsens, the man decides to confess all of his sins to the community, endangering his chances of getting a necessary liver transplant. Meanwhile, Taub and Chase return and House insists on knowing the paternity of Taub's two daughters.
House and his team take on the case of Ben, a teenager who aspires to be a circus clown like his biological father, who died years ago. When Ben becomes ill, the team need to find a compatible bone marrow donor and learn a dark secret about the family. Meanwhile, Taub ponders fatherhood when his wife wants to move to Portland with their daughter, and House tries to bypass his ankle monitor and go to a boxing match in Atlantic City with Wilson.
A 14-year-old girl suffers from an allergic reaction at her birthday party, but House is more interested in solving the death of a 4-year-old boy several years previously, despite the fact that he has to violate his parole to do so. Meanwhile, the team wonders why Chase has taken an interest in personal grooming.
The team treats a prosecutor suffering from what at first appears to be an anxiety attack. However, his symptoms soon grow worse and the man manifests extreme paranoia. While the doctors try to determine whether the paranoia is a symptom or not, Park grows paranoid about whether the others like her. Meanwhile, Wilson goes to extreme lengths to prove that House is paranoid enough to keep a gun, and Foreman believes Taub is trying to set him up on dates.
A man suffering from Alzheimer's coughs up blood and flies into violent rages. While the team tries to diagnose him, House tests Foreman's limits, and Wilson takes the case of a woman who claims that she and her boyfriend have an asexual relationship.
House and his team treat an underage runaway girl who refuses to identify her parents, and House takes a personal interest in the case. Meanwhile, Taub tries to find common ground with his infant daughters, Foreman's affair takes a surprising turn, and House treats two brothers who engage in Civil War reenactments.
When a team member is injured while treating a patient, Foreman brings in his old mentor Dr. Cofield to get to the truth. However, it soon becomes clear that someone is at blame... even though the team insists that nobody is to blame.
To cope with his near-death experience, Chase seeks out an emotional bond with a nun preparing to take her vows, who is in the hospital with a life-threatening disease. Meanwhile, Taub tries to cope by learning self-defense, and House puts Taub's newly acquired skills to the test.
While House tests his team by declaring that one of them will be his new second, they treat a marriage coach who suffers from fever, uncontrollable self-urination and double-vision. It turns out that low testosterone levels are the cause, but the patient worries that the treatment may change him into a man that his wife doesn't want.
House and his team treat a blind man suffering from auditory hallucinations, but his condition soon worsens. Meanwhile, Blythe House arrives in town with news for her son.
The team treats an Army PFC suffering from abdominal pains, who leaked a video of a botched military operation to the Internet and is awaiting a court marital. His condition gets progressively worse but he refuses treatment until the Army provides him with the files that will prove how his father, a military officer, really died. Meanwhile, the team comes to believe that House has a liver condition that will result in his death, but he refuses to accept their diagnosis.
A 22-year-old minor league hockey player collapses on the ice, coughing up blood. While the team tries to diagnosis his condition, Chase offers to let Park move in with him and House gives Wilson some mixed news.
House and his team handle the case of a man who cries blood, and discover that he has a unique ladyfriend who may be contributing to his health issues. Meanwhile, House auditions new hookers when his old one gives up the business for a husband. However, when he discovers he can't do without, House recruits Dominika to help ruin the relationship.
House's team treat a boy who is apparently possessed by demons, and they must deal with the mother's slowly developing belief that faith rather than science holds the answer to her son's cure. Meanwhile, Park and Chase have sex dreams about each other, and House lies to Dominika to keep her with him.
When House takes some vacation time to be with Wilson, the team must go on without him and handle the case of a six-year-old girl suffering from a genetic mutation which may or may not account or her current symptoms. Further complicating the situation is the fact that the girl's mother is a doctor and insists on treating her daughter. Meanwhile, House helps Wilson... whether his friend wants his help or not.
While the team takes on the case of a resident pathologist who refuses treatment from anyone except House, House and Wilson go on a road trip to Cleveland to see Julie Christie. Meanwhile, Chase wonders if he should stay or go.
The team tries to deal with a patient, Derrick, who suffers from nosebleeds, dizziness, and the voice of his dead brother in his head. However, Park, Adams, and Taub are on their own after Chase resigns and House spends his time trying to convince Wilson to undergo chemotherapy to stay alive as long as possible despite the cancer eating away at him.
In the series finale, House treats a heroin-addicted patient whose outlook on life puts House in a burning building haunted by the ghosts of his past.