Cathy Davis, a former secret agent, is reluctantly coaxed back into helping her old partner solve a mystery of disappearing top secret computer software.
Cathy, AKA Jane Doe, helps Frank get used to working with an old girlfriend while more importantly helping him catch a criminal who stole the Declaration of Independence and leaves clues behind.
Cathy investigates the disappearance of a narcotics dealer that has recently broken out of jail, all while pondering if telling her husband about her secret life will make things better or worse.
Cathy is called in to try and find a missing woman when a U.S. Attorney's wife goes in for plastic surgery, but when the bandages are removed, they find that it isn't her. Meanwhile, Cathy has to also prevent a long-term investigation of international terrorism and money laundering from falling apart.
As soccer-mom-turned-government-operative, Cathy has to tackle a tough secret assignment: find a missing British agent whose memory includes the names and addresses of every British agent in the Middle East. Was he kidnapped, or did the man arrange his own disappearance? Finding him is crucial, but keeping Cathy’s intuitive, ex-agent mom out of the picture proves difficult. Cathy’s decoding DNA leads her to find the answer and rediscover her most influential female role model: her mom.
Frank calls Cathy in to prove that it was murder when a former CSA agent, Jim Monroe, is fired from the staff of a billionaire cereal company CEO just hours from when he dies in a suspicious drowning accident.