Miguel's drug cartel is in trouble. Uncle Jorge Perez is hiding from the law on a houseboat, and the man left in charge, Ernesto Perez is somewhat insane, and too aggressive (Enresto is Jorge's son). The DEA is closing in, and the drug cartel is rapidly falling apart.
The family gathers for Uncle Jorge's funeral, and as they pay respect to him, they also fight over succession to the head of the family drug cartel. Miguel attempts to become the head of the cartel, but various family members, including his Uncle Beto, refuse to submit to his rule. They prefer to become the head of the cartel themselves.
Meanwhile, DEA Agent Flores is angry that her partner was killed while on an assignment with her, and she desires to track down his killer. Office politics, though gets in the way of her pursuit of justice or revenge. Dr. Klein, the plastic surgeon with connections to the Mexican drug cartel that Miguel is fighting to control, has acquired great wealth from his connections, but wants to get out.
Miguel tries to expand the business by setting up a multimillion-dollar deal with a Thai heroin kingpin (Khun Chao). Unfortunately trouble develops when Chao demands to receive the cocaine before he will send the first shipment of heroin. Lomo, Miguel’s partner, dislikes this demand, and hesitates to complete the deal. A meeting is set-up.
Meanwhile, Dr. Klein’s divorce is proceeding, but the almost ex-wife demands a huge cash settlement before she will accept/consent to/allow the divorce to go through. Dr. Klein doesn’t exactly have the money available, so he tries to avoid having to pay the cash by setting up a fake mugging.
Marlene's drug addiction is discovered by Miguel, her husband, and he sends her to a rehabilitation clinic. He will not let her return until she is "clean." Meanwhile, Miguel's brother Chato is sleeping with Ariela Lazareno, the police chief's wife. While Miguel attempts to deal with these personal issues, a foreign scientist offers a business opportunity from his discovery of a smell-less liquid heroin product.
Dr. Klein finds himself needing to return to the drug dealer business to try to pay off his future ex-wife.
Chato’s affair comes to the attention of the husband, who promptly locks up Chato to try to teach him a lesson. Miguel tries to get Chato out of lock-up, and has a good chance to do so, since that police officer is on the payroll of Miguel’s drug cartel. Meanwhile, Miguel’s son has been found drinking from the sacred chalice, and Miguel must find some way to deal with this situation.
Tension mounts as the government starts to crack down on the drug cartels. Miguel attempts to protect his wife and son by sending them off to the US. With them gone, war erupts. Politicians, drug cartel members die. And Dr. Klein believes that salvation lies in DEA protection.