Charles returns to Walnut Grove to find out that Albert has blood disease that almost always results in death.
The Ingalls find out that Walnut Grove is being bought by a miner. They decide to blow up the town since they are being forced to leave.
Rose is kidnapped by a woman who wants a child of her own.
The Ingalls sell their home and leave Walnut Grove, and Laura quits teaching to stay home with Rose.
Royal, Almanzo's brother, wants his brother and Laura to take care of his daughter, Jenny, because he is dying. Jenny tries to kill herself, upset by her father's death.
After Harriet finds a Walnut Grove bearer bond while cleaning Lars Hanson’s home, she demands that if the town doesn’t change its ways to suit her family; then they will have to pay her over $14,000. However, Harriet gets a surprise when one of the town founders comes into Walnut Grove during the town’s first mayoral election with the intent of having his bond being paid off before hers.
Mr. Stark tries to kill his wife and daughter after going bankrupt. He somehow gets in the Wilder house, and mistakes Laura and Jenny for his wife and daughter.
Mrs. Oleson tries to keep Lou Bates, a little person who has recently lost his wife in childbirth, from getting a job.
The people of Walnut Grove try to rescue a boy who cannot speak when they see him apart of a carnival show.
Mr. Edwards is hiding the boy, but is ordered by a judge to put him in a mental hospital.
Nellie comes back to Walnut Grove, making Nancy run away.
A company come into build a new railroad through walnut grove. They need the Carter's land to do it.
The community come together to stop the building of the rail road
When a former student from Walnut Grove’s Blind School returns to town, she and Mr. Edwards soon hit it off. After learning that Jane will be undergoing a surgery to restore her sight, Mr. Edwards starts to worry that she won’t want to be with him after she discovers the difference in their ages.
When a new minister comes to town, Mr. Edwards believes that he is out to get Reverend Alden's job and to turn the heads of the married women in town, especially those of Laura and Sara. Meanwhile, John and Almonzo run into some bad luck while going to a Grange meeting in San Francisco.
Jenny almost drowns in a swimming accident. Dr Marvin helps Jenny with her recovery and in returns she helps him too.
Sara Carter's father turns up in walnut grove after the death of his wife. He wants Sara and her family to go back west with him. Mrs Oleson writes a story in the local newspaper which has dire consequences to a local resident.
The older brothers get out of Jail, and are looking for an easy way to make money. Mr Edwards is caught up with them.
Laura goes to Minnesota with her book, in the hope that it will be published.
Charles is working in the city, he is having to work late nights to make ends meet, a policeman comes to the shop to inform him that Albert has been caught stealing from a shop again. After a chat with the owner of the shop he is willing to let Albert away with it if Charles gets him help.
Charles confronts Albert over his problem and wants to help himt. Albert runs away after a confrontation at the school and Charles, Mr Edwards and Doc Baker go looking for him.
After Laura and Almonzo's son dies, a grieving Laura blames Doc Baker, causing the rest of the town to turn their backs on him. However, when Rose comes down with small pox, Laura reluctantly lets the doctor treat the baby.
A former visitor returns to Walnut Grove for her final summer. She strikes a bond with young Jason Carter whilst he helps get her summer house back to livable conditions.
Mr. Edwards is on a trip home when he meets Buffalo Bill. Shortly after meeting Buffalo Bill dies and asks Mr Edwards to look after his 3 year old girl Blanche who soon causes trouble. Mrs Oleson and Nancy take a disliking to Blanche.
As he gets ready to graduate, Willie surprises his parents by telling them that he has no intention of going to college. Instead, he wants to stay in Walnut Grove, run the restaurant, and marry his sweetheart Rachel Brown.
After an old friend passes away, Laura and Almonzo are surprised to learn that she willed them her home. Not wanting the large house to go to waste, Laura decides to turn it into a boarding house and soon discovers that a world famous author would like to rent a room. Meanwhile, Mr. Edwards is thrown for a loop when Matthew’s father arrives in Walnut Grove, looking to be apart of his son’s life.