A trucker is playing pool at a bar & grill and has to go outside to urinate. He hears a man yelling from a nearby truck and goes to investigate. The noises cut off and the trucker goes away. Behind him, the passenger door is explosively shoved off from the inside. The next day, the owner goes out and sees deer standing around the truck. As he looks on in astonishment, they fade away from view.
Detective Dwight Faraday wakes up in his pigsty of an apartment and is confronted with a mounted photo of his ex-wife. Depressed, he goes into the station where he works in Animal Attacks. Officer Jacob Reed has him come to the bar & grill where they determine that the trucker was brutally pulped to death, apparently by some kind of animal. Faraday talks to witnesses who say the trucker was drunk and went outside with a beautiful sexy Native American woman with yellow eyes. Faraday is interrupted when homicide detective Patterson comes in and takes over the case. Faraday ends up dealing with the case of a monkey attacking a dog, but is distracted by the trucker's murder. He finally talks to the coroner, Dana, and she reports that the man died in a state of sexual arousal. Further, he was hit so hard that it looks as if a truck ran him over. Checking the corpse out, Faraday notices that there are hoof prints on the corpse.
The Native American woman, wearing a long skirt, approaches a businessman in a bar. She doesn't say anything but smiles enticingly and gets him to come back to his room with her. There she takes off her top and proceeds to give him oral sex.
Dana and Faraday try to come up with theories to account for the trucker's death. Faraday goes home and tries to imagine theories of the mysterious girl beating the trucker to death with a stuffed deer leg, a killer deer, and a weredeer killing the trucker and abducting the girl. He's not impressed with any of them.
The Native American woman goes to a pawnshop and comes on to the owner.
The next day, Ross tells Faraday about the businessman's death. He tries to strike up a conversation with Faraday about why he was transferred to Animal Attacks but Faraday simply says that he and his wife are separated. They go down to the morgue to check out the businessman and figure he died the same way. Dana confirms there were deer hairs on the corpse that came loose during a struggle. The eyewitness reports match those at the scene of the trucker's death and Faraday realizes they're connected. They get word that the pawnshop owner is dead and go to the scene. Patterson and his partner Fuches are investigating the murder and Faraday spots the dead man's arm on top of the building. They go up and Faraday notices bloody hoof prints that indicate something with two legs ran across the roof. Faraday heads home and notices a mural with Native American images, including those of a "Deer Woman." He is attacked by a mugger and disarms the man, stabbing him in the arm. Rather than arrest him, Faraday tells him to go to the hospital and get off the streets. He's unaware that the Native American killer is watching him from the shadows.
Faraday goes to his boss, Einhorn, and tries to convince him that some new type of animal is the killer. Patterson and Fuches are there and aren't thrilled with Faraday's theory, but Einhorn decides to give Faraday the case. Ross invites Faraday to lunch at an Indian casino and Faraday finally admits that he accidentally shot his partner while taking down a junkie. After that, he was investigated and eventually cleared, but lost his wife and friends. They talk about the murders and the casino manager, a Native American, overhears them. He tells them about the Native American legend of a "Deer Woman" with the legs of a deer. She comes out of the woods to sexually entice men and then stomps them to death. The manager notes that she doesn't have any motive, and that there is no known way to kill her.
Ross stays at the casino to gamble while Faraday goes back to the station. Ross loses for a while until the Deer Woman approaches him. Unaware of who she is, Ross lets her help him at the crap table and then takes her back to his apartment. Faraday calls him with news that he's discovered a similar series of murders a hundred years ago, and Ross realizes who he is with. Faraday rushes to the apartment but Ross is dead, stomped to death. The Deer Woman emerges from the shadows and Faraday shoots her. He feels guilty about shooting another person until he pulls away her skirt to reveal deer legs. The Deer Woman comes back to life and kicks him into the wall, then jumps out the window. Faraday goes in pursuit in his car and tries to cut her off on a country road, but she kicks his car away. Faraday drives after her and slams her against a tree, but she starts to shove it away. Faraday shoots her repeatedly but she's unaffected and then vanishes into thin air. The police arrive and Faraday can only mutter that it was an animal attack.
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