Medical Center is concerned with male menopause with William Windom as a respected surgeon who suddenly acts strangely with everyone. William Windom and Laraine Day guest-star as surgeons Brandon and Arlene Gillette, whose marriage is foundering due to his secret and obsessive fear of aging. Arlene is confused and distraught by her husband's uncharacteristic outbursts of temper and sarcasm that are estranging her as well as his friends and colleagues. The mutual attraction between Brandon and young Maria Landsdowne, a patient he is treating for a critical ailment, inflames the situation even more. Yet Brandon refuses to reveal to anyone, including close associate Dr. Joe Gannon, what is tormenting him.