Detective Dwight Hendricks (Jason Lee) investigates the abuse of elderly woman who happens to be a legendary Memphis disc jockey known as the “First Lady of the Airwaves.” But his loose investigative style is cramped by his new by-the-book boss, Lt. Tanya Rice (Alfre Woodard), who brings a den mother approach to her job. Meanwhile, Dwight’s mother (Celia Weston) starts dating a charming new neighbor.
Dwight and Whitehead search for a missing truck driver after his young son tells his classmates he was kidnapped. Juliette Lewis guest stars as Cleo Groves, a mother who will stop at nothing to hold her family together, even as poverty and the terrible secret of her husband's disappearance threaten to tear them apart. Meanwhile, Dwight tries to come to terms with his mother dating a man he doesn't trust. And Dwight's ex-wife, Alex, keeps sending mixed signals.
A missing teenage beauty pageant queen has the entire squad on the trail, but every corner they turn seems to reveal another level to her complicated situation. Dwight tries to help his ex-wife, Alex, get her health-food catering business off the ground. And everyone's concerned about the way Lightfoot's wife has been treating him.
When a fellow Restaurant owner gets stabbed, Dwight and Charlie investigate to who would kill him. In the midst of a traditional barbecuing contest, the pressure is on and the detectives have to think of different methods in order to catch the culprit red handed. But things spiral out of control and things make a turn for the worse. Meanwhile, Dwight comes to a reality that has been missing for a while.
Dwight and Whitehead are called when a country band's manager is found dead outside the memorial service of Darlene "Ma" Boswell. With signs pointing to suicide, Dwight doesn't agree with them. There is a murder and Dwight has to put the piece together mix in with a family that, on stage, are the best of friends, but off the stage are a walking trainwreck. Will Dwight and Charlie be able to find the murderer amongst a schizophrenic, a distraught member of the band and other leads?
After very popular local boxer is beaten up, suspicion falls on several people who stood to lose a lot from his impending retirement. Sutton goes on a quest to correct a missed opportunity from his past.
When a private plane is found abandoned in a riverside park, the squad hits the trail in search of a pair of the owners, a couple of elderly lottery winners who may have been kidnapped. Meanwhile, Greenback catches a close friend in a compromising position. And Lt. Rice catches the eye of a handsome Air Force officer.
Dwight tries to resolve a hostage crisis by becoming a second hostage. He then proceeds to dig through his captor’s past to learn the truth about a decades-old cold case with connections that stretch from Memphis to Louisiana. Meanwhile, Lt. Rice’s ex-husband causes her problems. Clarence Williams III (The Mod Squad) and Veronica Cartwright (Alien) guest-star.
An aid to a city councilman disappears on the day of his wedding to the councilman’s daughter. But a missing reporter, a cryptic phone message and a pair of cufflinks prove there’s more to the situation than a groom’s cold feet. Meanwhile, Dwight’s mother makes a big life decision that leaves Dwight a little uncertain about the future.
A man with amnesia turns up with a bullet wound in the middle of a seedy section of Memphis, leading Dwight to believe he may be connected to a three-year-old unsolved case involving the beating death of a little girl. Lt. Rice, facing financial difficulties after her ex-husband steals a large sum of cash, contemplates a career change.
The squad is plunged into a case involving the death of an admired police officer who may have been involved with a white supremacist group. The case hits home for Dwight, who relates to the son of the officer left behind. It also introduces Dwight to Claire Ryan, a tough investigator from Internal Affairs. Meanwhile, Rice starts riding Whitehead about taking the lieutenant's exam, but her reasons for wanting him to pass aren't exactly a vote of confidence.
A series of home burglaries has Hendricks and White looking into a previous unsolved series of similar burglaries from years ago. A very knowledgeable citizen comes forward to assist the investigation, much to Hendricks disgust.
A despondent father comes to Dwight to help search for his missing daughter. When it appears she may have been the victim of foul play, suspicion immediately falls on her abusive husband. Lt. Rice finds herself left out of a big piece of family news, and Whitehead goes to a surprising source when he needs to brush up his firearm skills.
Dwight and Whitehead are on the case of a reported missing person, but they are shocked to discover that a nun may be their prime suspect. And when Sutton discovers an abandoned baby in his car, he turns to Dwight’s mom, Paula Ann, to teach him baby basics.
When the Landmark Movie Theater, a beloved Memphis attraction, mysteriously burns down, Rice decides to sharpen her detective skills by working the case under Whitehead. Meanwhile, Dwight and Paula drive to New Orleans to talk to the man who shot Dwight's father. Dwight is determined to put to rest his suspicions that his father may have been a dirty cop.
Paula calls on Dwight to help one of his oldest friends, who has been arrested in a case involving three gunmen who robbed a party boat. Dwight’s investigation brings him face to face with an old flame and gives him a chance to perform with one of his old band members from his high school days.
In the middle of the funeral for a man known for helping at-risk kids, his body goes missing, and it' up to Dwight and Whitehead to find it.
Dwight and Whitehead are called to a local bank where a man has taken hostages, claiming he was the victim of a scam. Dwight promises to make things right for the man, but in doing so discovers this scam may go a lot deeper than he ever expected. Tony breaks up with Paula Ann, and Dwight has to pick up the pieces.
There’s a storm brewing in Memphis, and Dwight and Whitehead are off visiting a haughty Southern family from Whitehead’s past. When the storm worsens, the pair become trapped in a mansion during a murder investigation that is straight out of a “who done it” mystery novel. Meanwhile, back at M.P.D, Lt. Rice, Davey and Greenback have to help identify a man they found in jail with no clue how he got there.
In the Season 2 finale, a family feud reaches a fever pitch, resulting in the shooting of a girl. Meanwhile, Dwight's peers discover he has a new girlfriend. Dwight tries to separate his love life from his professional life, but that proves difficult.