Nurse Veronica Callahan has just returned to Mercy Hospital after a tour of duty in Iraq. Though not afraid to bend the rules in order to save a life, her outspoken attitude might cause her to lose her job. While trying to get over her broken marriage to Mike, she catches the eye of the newest doctor, Dr. Chris Sands. Meanwhile, Sonia, Veronica's best friend, thinks she may have found the one; and rookie nurse Chloe learns the hard way what it means to be a nurse.