The IMF must locate the wristwatch-camera of undercover agent Fred Stenrock, codename "Toledo," who had copied incriminating evidence against Syndicate gambling head Dutch Krebbs.To convince Dutch's lieutenant, Press Allen, to turn traitor and retrieve the watch, Jim goes undercover as an expert pool player... with some electronic assistance from Barney.
Physicist Joseph Collins has stolen plutonium and plans to sell it to a foreign power to make atomic bombs. The IMF must figure out where Collins hid the plutonium and identify his buyer before the deal goes down.
General Oliver Hammond, a British soldier of fortune, plans to take over the Republic of Camagua with Syndicate financial banking. Syndicate lieutenant Charles Rogan is bringing Hammond his $5 million payoff in the form of a safe deposit key. The IMF must get the key and get the money from the safe deposit box.
Undercover agent Louis Parnell has been exposed to Syndicate leader Mike Apollo. The IMF must discover his whereabouts and rescue him by framing Apollo for the murder of Syndicate member Mike Epic's wife. Apollo must bring Parnell out to produce him as a witness.
Dr. Victor Flory heads a terrorist organization, Alpha Group, and government scientist Paul Morse plans to sell him a biological weapon, TOD-5. Morse's contact is Gordon Holt, so the IMF must trick Holt into believing that TOD-5 has leaked and is devastating a small town... and that he has the plague.
Carl Reid and his right-hand man Joseph Conrad are the most important distributors of cocaine in the United States. Their ability to connect with supplier Fernando Larroca at will has baffled law enforcement. Emboldened by their success, they plan to import ten million dollars worth of the drug - misery on a titanic scale. The IMF must seal this pipeline and put its operators out of business for good.
Gunther Schnell, the head of the Syndicate's illegal money operations, is being smuggled out of the country and the IMF must locate Schnell and the millions he has hidden.
Norman Shields is running a Syndicate operation to take over the entertainment industry, and Theo Dane, the brother of his backer, is coming into town. The IMF must locate Shields' financial records and set him up by pretending to make a film based on a murder that Shields barely avoided prosecution for. Shields is unaware that the IMF plan to set him up for the fake murder of Theo Dane to turn his backer against him.
Sam Dexter is in jail for tax evasion, but suspected of murdering his girlfriend Vicki Wells. Dexter continues to run his crime empire from jail through a secret partner, The General. The IMF must turn Dexter against his silent partner to identify the man.
Dr. Jerome Cooper, a nuclear physicist, is trying to force the surrender of the U.S. government to his control, using the thread of a hidden hydrogen bomb. The IMF must convince him the President is giving in to his demands, then keep him trapped in a roadside diner so he'll contact his accomplice to disarm the nuclear device.
Syndicate chief Andrew Metzger has identified Jim and Barney while on vacation, from a previous mission, and takes Jim hostage to force the team to get an incriminating letter out of a bank deposit box and deliver it to him. However, when Metzger's assistant Hawks steals the envelope from the team, they must create a fake letter and get into the air raid shelter where Jim is a prisoner.
Hitman and chess master Peter Cordel works for the Syndicate, and the IMF must turn him against his unknown employers by giving him blackouts and convincing him the Syndicate is trying to kill him.
Syndicate boss Paul Ostro is planning a major hundred million dollar crime operation, using his younger brother Leo as spokesman after being injured in a hunting accident. It becomes clear that Leo is running the entire scheme and concealing the fact his brother died to use him as a figurehead in his scheme. The IMF must turn the tables on him by convincing Leo's Syndicate backers that Paul is alive... and believes Leo tried to kill him.
Hannah O'Connel and her two sons lead a gang that stole a million dollars in gold bullion. One son, Robert, has testified against her for tax fraud. Robert has disappeared and Hannah and her other son Thomas have fled to a Caribbean country with no extradition treaty. The IMF must con Hannah into coming back onto U.S. soil by convincing her that Robert (who she killed) is still alive and she needs a voodoo exorcism.
Syndicate executive John Vayle dies in a plane crash, a death caused by his wife Eve. Eve plans to use her husband's records to blackmail his superior, Stanley Luchek. The IMF must get the records to put Luchek away, by convincing Eve that her husband survived the crash and is trying to get the records back.
Assassin Nicholas Varsi wants to defect, but the U.S. government is suspicious of his sincerity. He's being kept by the Federal Intelligence Service, but they've been infiltrated so the IMF must kidnap Varsi from them then determine if he's telling the truth about defecting.
Aging Syndicate executive Thomas Bachman has stolen criminal records as part of a power struggle against his rival, a crippled Matthew Drake. The IMF must recover the records before Drake does, and convince both men that they have discovered the Golden Circle, a cult that has access to a fountain of youth.
Syndicate executive Jay Braddock has corrupted promoter Paul Mitchell and made him a partner in his ownership of a stable of boxers. The IMF must turn Mitchell against Braddock by setting him up for the (fake) execution of Mitchell's daughter Susan, who is dating a boxer who has defied them.
Syndicate drug dealer Sam Hibbing has stolen three tons of D-amphetamine sulfate from a chemical plant and has it at a secret location. The IMF must recover the drugs and put Hibbing out of business.
A terrorist organization, Pendulum, is led by Gunnar Malstrom and has a major operation, codename Nightfall, planned. The IMF pretend to be a rival terrorist organization and learn that Malstrom plans to kill an Air Force General... unaware that the real plan involves substituting a fake general and blowing up the Joint Chiefs of Staff.
Master thief Van Cleve robs the Azteca Museum of valuable artwork and kills his partner, Matthew Royce. The art is now in the U.S. and the IMF must convince Van Cleve that he is having precognitive visions so they can trick him into going to recover the treasure.
The Marnsburg Crown Jewels have been stolen on their way to the U.N. for display. The government of Marnsburg has kept the theft secret for now, and the IMF must go after suspected thief Jena Cole and retrieve the jewels within the next 72 hours.