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Savannah ("Savi") is a successful career woman working toward the next phase in her life -- both professionally and personally -- bucking for partner at the law firm where she works while also trying to start a family with her husband, Harry. But when their fertility issues begin to take center stage, Savi finds herself attracted to her flirtatious colleague, Dominic. Savi's free-spirited and capricious baby sister, Josslyn, couldn't be more different, living single, serial dating and partying. A real estate agent, Josslyn has no interest in a committed, long-term relationship.
Their common best friend, April, is a recent widow and mother of a ten-year-old daughter. After she receives her late husband's lucrative life insurance check, she begins getting prank phone calls and tells her closest girlfriends that she's convinced her husband is still alive. Another long-time friend, Karen, is a therapist with her own thriving practice, reconnecting with the girls after her involvement in a complicated relationship with a wealthy, married patient goes too far: She was having an affair with a terminally ill client to whom she had prescribed morphine.