Philadelphia (4-12 in 2012) at Washington (10-6). QB Robert Griffin III and LB Brian Orakpo return from injuries for the Redskins, while Philly opens the Chip Kelly era with Michael Vick at QB. Washington won 31-6 and 27-20 last season in its first series sweep since 2008.
Houston (12-4 last season) at San Diego (7-9). Texans LB J.J. Watt looks to disrupt a San Diego attack bolstered by rookie tackle D.J. Fluker. Ex-Broncos assistant Mike McCoy takes over as head coach of the Chargers, who are 4-0 in the all-time series.
Pittsburgh (0-1) at Cincinnati (0-1). QB Andy Dalton and the Bengals edged Pittsburgh 13-10 last December to snap a five-game series losing streak and clinch their second straight playoff berth. Pittsburgh has a 7-1 Monday-night record under Mike Tomlin.
Final Score: Pittsburgh 10, Cincinnati 20
Oakland (1-1) at Denver (2-0). Potent passer Peyton Manning and scrambling Raiders QB Terrelle Pryor share the spotlight in this bitter AFC West rivalry, which has gone Denver's way three straight times since Oakland's Monday-night road win in 2011.
Final Score: Raiders 21, Broncos 37
Miami (3-0) at New Orleans (3-0). Drew Brees and the Saints bid for their ninth straight Monday-night win, while the Dolphins chase their first 4-0 start since 1995. New Miami LB Dannell Ellerbe was a Super Bowl winner with the Ravens here last season.
Final Score: Dolphins 17, Saints 38
New York Jets (2-2) at Atlanta (1-3). Mike Smith's Falcons face their third straight AFC East foe after losses to the Dolphins and Pats. The Jets feature rookie QB Geno Smith and ex-Georgia Tech safety Dawan Landry. Both teams are on 2-6 skids on MNF.
Final Score: Jets 30, Falcons 28
Indianapolis (4-1) at San Diego (2-3). Second-year standouts Andrew Luck and Trent Richardson make their Monday-night debuts as the Colts bring a 2-0 road record to Qualcomm Stadium. Indy's last visit was a 2008-09 wild-card loss in overtime, San Diego's last playoff win.
Final Score: Colts 9, Chargers 19
Minnesota (1-4) at New York Giants (0-6). New QB Josh Freeman steers the Vikings' bid to snap a five-game Monday-night losing streak, which includes a loss in their last game vs. New York (2010). Adrian Peterson and Brandon Jacobs face weak run defenses.
Final Score: Vikings 7, Giants 23
Seattle (6-1) at St. Louis (3-4). The Seahawks put their six-game MNF win streak on the line at the Jones Dome, where they lost 19-13 last year as Greg Zuerlein hit field goals of 60 and 58 yards. Marshawn Lynch ran for 218 yards in the teams' 1-1 split.
Final Score: Seahawks 14, Rams 9
Chicago (4-3) at Green Bay (5-2). The Packers have taken the last six meetings with division-rival Chicago, including two wins last season in which the Bears were held under 200 yards. Journeyman QB Josh McCown fills in for Chicago's injured Jay Cutler.
Final Score: Bears 27, Packers 20
Miami (4-4) at Tampa Bay (0-8) in a Sunshine State clash featuring ex-Miami Hurricanes RBs Lamar Miller and Mike James, who both had their first 100-yard game last week. The Bucs' last home win was last Nov. 11, while Miami is on a four-game skid on MNF.
Final Score: Dolphins 19, Buccaneers 22
New England (7-2) at Carolina (6-3). Bill Belichick's Patriots bid for their sixth straight Monday-night win, facing third-year QB Cam Newton and red-hot Carolina. New England TE Rob Gronkowski faces a stifling Panthers defense led by LB Luke Kuechly.
Final Score: Patriots 20, Panthers 24
San Francisco (6-4) at Washington (3-7). Mobile QBs Colin Kaepernick and Robert Griffin III duel at FedEx Field, while Brian Orakpo and NaVorro Bowman loom at linebacker. San Francisco is tied with Dallas atop the all-time Monday-night wins list with 43.
Final Score: 49ers 27, Redskins 6
New Orleans (9-2) at Seattle (10-1). Drew Brees and the Saints put their nine-game MNF winning streak on the line against defensive backs Earl Thomas and Richard Sherman of well-rested Seattle, which won the last meeting 41-36 in a 2010 wildcard playoff.
Final Score: Saints 7, Seahawks 34
Dallas (7-5) at Chicago (6-6). Cowboys RB DeMarco Murray and Chicago WRs Brandon Marshall and Alshon Jeffrey face suspect defenses at Soldier Field. The Bears beat Dallas 34-18 on MNF last season as Tony Romo threw 5 INTs, with two returned for TDs.
Final Score: Cowboys 28, Bears 45
Baltimore (7-6) at Detroit (7-6). John Harbaugh's Ravens fly into Motown with just a 1-5 road record after excelling away from home en route to last season's Super Bowl win. Return men Jacoby Jones (kick) and Jeremy Ross (kick, punt) had TDs last week.
Final Score: Ravens 18, Lions 16
Atlanta (4-10) at San Francisco (10-4) in the 49ers' final regular-season game at Candlestick Park, a rematch of last season's NFC title game, won 28-24 by San Francisco after the Falcons led 17-0. Veteran RBs Steven Jackson and Frank Gore are featured.
Final Score: Falcons 24, 49ers 34